The microRNA-183 cluster: the family that plays together stays together

Dambal, Shweta; Shah, Mit; Mihelich, Brittany L.; Nonn, Larisa

doi:10.1093/nar/gkv703

Cited by 184 publications

(198 citation statements)

References 190 publications

(253 reference statements)

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“…miRNA is involved in various biological processes, including cell proliferation, apoptosis, metabolism and differentiation. miR-183-96-182 cluster is a highly conserved miRNA cluster [2]. Members of this cluster are located within a 5-kb region on human chromosome 7q32.2 [3], transcribed in the same direction from telomere to centromere, and have similar biological functions in some of the closely related signaling pathways.…”

Section: Introductionmentioning

confidence: 99%

“…While investigating its regulatory effect on the downstream target genes, the miR-183-96-182 cluster was discovered as being a regulator of tumor development, the nervous system and the immune system [2, 28–34]. Recent studies have documented localization of some tumor-related genes, such as CDK6, BRAF, and c-MET at the upstream/downstream domain of miR-183-96-182 cluster [23, 35, 36], suggesting that these genes might be regulated to process similar functions of tumor-related molecules.…”

Section: Introductionmentioning

confidence: 99%

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Dysregulation and functional roles of miR-183-96-182 cluster in cancer cell proliferation, invasion and metastasis

Liang

Fan

et al. 2016

Oncotarget

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Previous studies have reported aberrant expression of the miR-183-96-182 cluster in a variety of tumors, which indicates its' diagnostic or prognostic value. However, a key characteristic of the miR-183-96-182 cluster is its varied expression levels, and pleomorphic functional roles in different tumors or under different conditions. In most tumor types, the cluster is highly expressed and promotes tumorigenesis, cancer progression and metastasis; yet tumor suppressive effects have also been reported in some tumors. In the present study, we discuss the upstream regulators and the downstream target genes of miR-183-96-182 cluster, and highlight the dysregulation and functional roles of this cluster in various tumor cells. Newer insights summarized in this review will help readers understand the different facets of the miR-183-96-182 cluster in cancer development and progression.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dysregulation and functional roles of miR-183-96-182 cluster in cancer cell proliferation, invasion and metastasis

Liang

Fan

et al. 2016

Oncotarget

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“…Genes encoding several identical or similar miRNAs are generally located as a cluster in the genome, where they might be expressed simultaneously [16] or individually depending on the tissue types [17]. In mammals, RNA polymerase II transcribes the gene into a long transcript known as a primary miRNA (pri-miRNA) consisting of single or multiple hairpin structures (Fig.…”

Section: Biosynthesis and Mode Of Action Of Mirnamentioning

confidence: 99%

Mammalian microRNA: an important modulator of host-pathogen interactions in human viral infections

et al. 2016

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MicroRNAs (miRNAs), which are small non-coding RNAs expressed by almost all metazoans, have key roles in the regulation of cell differentiation, organism development and gene expression. Thousands of miRNAs regulating approximately 60 % of the total human genome have been identified. They regulate genetic expression either by direct cleavage or by translational repression of the target mRNAs recognized through partial complementary base pairing. The active and functional unit of miRNA is its complex with Argonaute proteins known as the microRNA-induced silencing complex (miRISC). De-regulated miRNA expression in the human cell may contribute to a diverse group of disorders including cancer, cardiovascular dysfunctions, liver damage, immunological dysfunction, metabolic syndromes and pathogenic infections. Current day studies have revealed that miRNAs are indeed a pivotal component of host-pathogen interactions and host immune responses toward microorganisms. miRNA is emerging as a tool for genetic study, therapeutic development and diagnosis for human pathogenic infections caused by viruses, bacteria, parasites and fungi. Many pathogens can exploit the host miRNA system for their own benefit such as surviving inside the host cell, replication, pathogenesis and bypassing some host immune barriers, while some express pathogen-encoded miRNA inside the host contributing to their replication, survival and/or latency. In this review, we discuss the role and significance of miRNA in relation to some pathogenic viruses.

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“…1). This miRNAs is expressed in a completely synchronous manner throughout development and is needed for maturation of sensory organs [16]. miR-96, mir-182, and miR-183 comprise a fully conserved family of miRNAs and localize in intergenic loci of chromosome 7 long arm (Fig.…”

Section: The Mir-183 Familymentioning

confidence: 99%

MicroRNA-183 Family in Inner Ear: Hair Cell Development and Deafness

sani

Hashemzadeh‐Chaleshtori

Saidijam

et al. 2016

J Audiol Otol

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miRNAs are essential factors of an extensively conserved post-transcriptional process controlling gene expression at mRNA level. Varoius biological processes such as growth and differentiation are regulated by miRNAs. Web of Science and PubMed databases were searched using the Endnote software for the publications about the role miRNA-183 family in inner ear: hair cell development and deafness published from 2000 to 2016. A triplet of these miRNAs particularly the miR-183 family is highly expressed in vertebrate hair cells, as with some of the peripheral neurosensory cells. Point mutations in one member of this family, miR-96, underlie DFNA50 autosomal deafness in humans and lead to abnormal hair cell development and survival in mice. In zebrafish, overexpression of the miR-183 family induces extra and ectopic hair cells, while knockdown decreases the number of hair cell. The miR-183 family (miR-183, miR-96 and miR-182) is expressed abundantly in some types of sensory cell in the eye, nose and inner ear. In the inner ear, mechanosensory hair cells have a robust expression level. Despite much similarity of these miRs sequences, small differences lead to distinct targeting of messenger RNAs targets. In the near future, miRNAs are likely to be explored as potential therapeutic agents to repair or regenerate hair cells, cell reprogramming and regenerative medicine applications in animal models because they can simultaneously down-regulate dozens or even hundreds of transcripts.

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The microRNA-183 cluster: the family that plays together stays together

Cited by 184 publications

References 190 publications

Dysregulation and functional roles of miR-183-96-182 cluster in cancer cell proliferation, invasion and metastasis

Dysregulation and functional roles of miR-183-96-182 cluster in cancer cell proliferation, invasion and metastasis

Mammalian microRNA: an important modulator of host-pathogen interactions in human viral infections

MicroRNA-183 Family in Inner Ear: Hair Cell Development and Deafness

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