The microRNA-221/-222 cluster balances the antiviral and inflammatory response in viral myocarditis

Corsten, Maarten F.; Heggermont, Ward; Papageorgiou, Anna-Pia; Deckx, Sophie; Tijsma, Aloys; Verhesen, Wouter; Leeuwen, Rick van; Carai, Paolo; Thibaut, Hendrik Jan; Custers, Kevin; Summer, Georg; Hazebroek, Mark; Verheyen, Fons; Neyts, Johan; Schroen, Blanche; Heymans, Stéphane

doi:10.1093/eurheartj/ehv321

Cited by 96 publications

(58 citation statements)

References 39 publications

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“…The same miRNA was confirmed to play a major role in viral myocarditis, when miR-155 levels in mouse cardiac tissue were identified to increase during carditis in a macrophage dependent manner [130]. Another recent study found miR-221 and miR-222 as key regulators of the cardiac response to viral myocarditis [131]. This study was performed in cardiac tissue samples of myocarditis patients, as well.…”

Section: Infective Carditismentioning

confidence: 65%

microRNAs in cardiovascular disease – clinical application

Schulte

Karakas

Zeller

2017

Clinical Chemistry and Laboratory Medicine (CCLM)

107

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microRNAs (miRNAs) are well-known, powerful regulators of gene expression, and their potential to serve as circulating biomarkers is widely accepted. In cardiovascular disease (CVD), numerous studies have suggested miRNAs as strong circulating biomarkers with high diagnostic as well as prognostic power. In coronary artery disease (CAD) and heart failure (HF), miRNAs have been suggested as reliable biomarkers matching up to established protein-based such as cardiac troponins (cT) or natriuretic peptides. Also, in other CVD entities, miRNAs were identified as surprisingly specific biomarkers -with great potential for clinical applicability, especially in those entities that lack specific protein-based biomarkers such as atrial fibrillation (AF) and acute pulmonary embolism (APE). In this regard, miRNA signatures, comprising a set of miRNAs, yield high sensitivity and specificity. Attempts to utilize miRNAs as therapeutic agents have led to promising results. In this article, we review the clinical applicability of circulating miRNAs in CVD. We are giving an overview of miRNAs as biomarkers in numerous CVD entities to depict the variety of their potential clinical deployment. We illustrate the function of miRNAs by means of single miRNA examples in CVD.

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Section: Infective Carditismentioning

confidence: 65%

microRNAs in cardiovascular disease – clinical application

Schulte

Karakas

Zeller

2017

Clinical Chemistry and Laboratory Medicine (CCLM)

107

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“…Inhibition of miR-211/miR-222 augments viral load and strongly aggravates CVB3-induced cardiac injury, whereas a high level of these 2 miRNAs reduces viral replication. 155 In brief, accumulated evidence indicates that CVB3-induced differential expression of miRNAs plays a crucial role in modulating host and viral gene expression, and in turn directly or indirectly promotes CVB3 pathogenesis.…”

Section: Virus-induced Direct Damagementioning

confidence: 99%

Myocarditis

Gabriel

Luo

Qiu

et al. 2016

Circulation Research

411

354

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“…The miRNA cluster from chr19 (miR‐512‐1/516a‐2) may be useful in the treatment of autoimmune diseases such as rheumatoid arthritis and Sjogren's syndrome (Bullerdiek & Flor, ). miR‐221/222 cluster regulates antiviral and inflammatory responses to viral infection of the heart (Corsten et al, ). miR‐212/132 cluster has shown to be altered in Alzheimer's disease (Pichler et al, ).…”

Section: Mirna Clusters and Other Diseasesmentioning

confidence: 99%

Clustered miRNAs and their role in biological functions and diseases

et al. 2018

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MicroRNAs (miRNAs) are endogenous, small non-coding RNAs known to regulate expression of protein-coding genes. A large proportion of miRNAs are highly conserved, localized as clusters in the genome, transcribed together from physically adjacent miRNAs and show similar expression profiles. Since a single miRNA can target multiple genes and miRNA clusters contain multiple miRNAs, it is important to understand their regulation, effects and various biological functions. Like protein-coding genes, miRNA clusters are also regulated by genetic and epigenetic events. These clusters can potentially regulate every aspect of cellular function including growth, proliferation, differentiation, development, metabolism, infection, immunity, cell death, organellar biogenesis, messenger signalling, DNA repair and self-renewal, among others. Dysregulation of miRNA clusters leading to altered biological functions is key to the pathogenesis of many diseases including carcinogenesis. Here, we review recent advances in miRNA cluster research and discuss their regulation and biological functions in pathological conditions.

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The microRNA-221/-222 cluster balances the antiviral and inflammatory response in viral myocarditis

Abstract: The miR-221/-222 cluster orchestrates the antiviral and inflammatory immune response to viral infection of the heart. Its inhibition increases viral load, inflammation, and overall cardiac injury upon VM.

Cited by 96 publications

References 39 publications

microRNAs in cardiovascular disease – clinical application

microRNAs in cardiovascular disease – clinical application

Myocarditis

Clustered miRNAs and their role in biological functions and diseases

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