The Microvasculature of the Human Pancreas and Its Relation to Langerhans Islets and Lobules

Yaginuma, Nobuhisa; Takahashi, Tohru; Saito, Ken; Kyoguku, Masahisa

doi:10.1016/s0344-0338(86)80191-1

Cited by 22 publications

(13 citation statements)

References 25 publications

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“…Moreover, it is hardly conceivable that these heterogeneous microorgans all have a uniform vasculature. Indeed, there are indications in the literature that the microcirculation pattern of islets may be diverse in the same species (Grube and Bohn 1983;Grube and Weimann 1985;Yaginuma et al 1986;J6rns et al 1988). Although canine islets generally possess a dense capillary network, we have shown that the pattern of vascularization may vary even within the same islet (see Ferner 1952 for similar observations in human islets), eventually along with changes of the microtopology of the endocrine cell types.…”

Section: Fig 7 A-i Three Different Planes Of Section Of the Same Issupporting

confidence: 64%

The microanatomy of canine islets of Langerhans: implications for intra-islet regulation

et al. 1992

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In recent years models for the internal ("intra-islet") regulation of hormone secretion have been proposed to explain how different islet cells might regulate each other by means of their respective secretory peptides. Models that emphasize the importance of a directed intra-islet blood flow and sequence of perfusion of islet cells rely on a certain type of islet microanatomy and vascular supply. The experimental studies underlying these models have partly been performed in dogs. To extend the incomplete morphological knowledge of the canine endocrine pancreas both canine islets of Langerhans and extrainsular cells have been analysed in immunostained serial semithin (0.5 microns) sections. In addition to their occurrence within islets of Langerhans, all endocrine cell types are also found at extrainsular sites (about 9% of all endocrine cells) where they are distributed in different quantities among the epithelial lining of exocrine acini or excretory ducts and the connective tissue. There are continuous transitions from single extrainsular cells to small mono- and polycellular cell groups to islets. In a comprehensive analysis of whole islets, including computer-assisted three-dimensional reconstructions, the size, shape and vascularization of the islets as well as their cellular composition and the microtopology of islet cells have been studied. We have found marked intra- and inter-islet heterogeneities of the parameters investigated that are not compatible with concepts of a uniform and directed vascular perfusion of the various islet cell populations. Instead, their paracrine regulation may occur primarily via hormonal secretion into the intercellular spaces or vascular hormonal delivery to adjacent cells.

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Section: Fig 7 A-i Three Different Planes Of Section Of the Same Issupporting

confidence: 64%

The microanatomy of canine islets of Langerhans: implications for intra-islet regulation

et al. 1992

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“…In addition, secretion of the exocrine pancreas is regulated by different islet hormones [2][3][4]. An islet-acinar portal system has been found in mammalian pancreas, through which exocrine pancreatic cells receive blood from adjacent islets [5,6]. Thus, the exocrine cells in the neighborhood of endocrine islets appear to be nourished by the islet drainage containing high concentrations of pancreatic hormones [7].…”

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confidence: 99%

“…Thus, the exocrine cells in the neighborhood of endocrine islets appear to be nourished by the islet drainage containing high concentrations of pancreatic hormones [7]. This angioarchitecture is potentially related to the intrapancreatic regulation of the exocrine pancreas, although the proportion of portal vessels in pancreatic microvasculature varies between the species investigated [5,6]. On the other hand, influences from normal pancreatic ducts or acinar cells on endocrine islets have also been observed in vitro under different experimental conditions [8,9].…”

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confidence: 99%

In VitroInfluences between Pancreatic Adenocarcinoma Cells and Pancreatic Islets

Wang¹,

Larsson²,

Adrian³

et al. 1998

Journal of Surgical Research

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“…The entire system is controlled by neurohormonal feedback mechanisms with integration of all sensory information in the dorsal vagal complex of the medulla oblongata, and function is driven by vagal efferents that extend to intrapancreatic ganglion, and on to the duct cells, the acinar cells, and the islet cells [3,4]. The acinar cells are dependent on the islet cells for proper function as they are bathed in the blood draining from the islets (islet-acinar axis [5]), and the connection of the acinar cells to the intestine is dependent on the ductsformed by the duct cells.…”

Section: Normal Pancreas Structure and Functionmentioning

confidence: 99%

Genetic studies of diseases

Whitcomb

Barmada

2007

Cell. Mol. Life Sci.

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Pancreatitis is usually inflammation of the pancreas without infection. Our understanding of pancreatitis has been built on autopsy studies, surgical biopsies and surrogate markers of inflammation and fibroses, including abdominal imaging techniques and pancreatic functional studies. However, the discovery that a number of different environmental factors and various genetic abnormalities are seen in patients with similar appearing pancreatitis phenotypes teaches us that end-stage pathology is not the disorder. Understanding complex associations and interactions requires that the components and their interactions be organized, stratified and functionally defined. Systems biology, in the broad sense, provides the approach and tools to define the complex mechanisms driving pathology. As the mathematics behind these pathways and mechanisms are defined and calibrated, the potential pathology of patients with early signs of disease can be predicted, and a number of patient-specific targets for intervention can be defined.

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The Microvasculature of the Human Pancreas and Its Relation to Langerhans Islets and Lobules

Cited by 22 publications

References 25 publications

The microanatomy of canine islets of Langerhans: implications for intra-islet regulation

The microanatomy of canine islets of Langerhans: implications for intra-islet regulation

In VitroInfluences between Pancreatic Adenocarcinoma Cells and Pancreatic Islets

Genetic studies of diseases

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