The midcingulate cortex and temporal integration

Procyk, Emmanuel; Fontanier, Vincent; Sarazin, Matthieu; Goussi, Clément; Wilson, Charles R.E.

doi:10.1016/bs.irn.2020.12.004

Cited by 4 publications

(2 citation statements)

References 124 publications

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“…LFP analyses indeed showed that feedback valence was detectable, for the 2 recorded monkeys, throughout the intertrial interval and even during the next trial. The computation and maintenance of the history of outcomes are considered one important property of the frontal cortex and especially of the MCC (Kennerley et al, 2006;Seo and Lee, 2007;Procyk et al, 2021). Interestingly, in the categorization task, the outcome has no informational relevance for the accuracy in the next trial.…”

Section: Modulation Of Performance During the Categorization Taskmentioning

confidence: 99%

“…Another point of interest is the putative anatomo-functional dissociations of performance monitoring and/or motivational processes compared with control or selection mechanisms. The medial frontal cortex, in particular the rostral subdivision of the midcingulate cortex (MCC), is activated during adaptive exploratory behaviors, with activity shown to negatively correlate with fatigue, and seems to be causally involved in integrating information to regulate decision-making (Müller and Apps, 2019;Procyk et al, 2021). Activity in the lateral prefrontal cortex (LPFC) is often correlated with the implementation of behavioral regulation through action or task set selection (Crowe et al, 2013;Donahue and Lee, 2015).…”

Section: Introductionmentioning

confidence: 99%

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The Differential Weights of Motivational and Task Performance Measures on Medial and Lateral Frontal Neural Activity

Goussi-Denjean,

Fontanier,

Stoll

et al. 2023

J. Neurosci.

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Behavioral adaptations are triggered by different constraints given by rules, and are informed by outcomes, or motivational changes. Neural activity in multiple frontal areas is modulated during behavioral adaptations but the source of these modulations and the nature of the mechanisms involved are unclear. Here we tested how different variables related to changes in task performance and to behavioral adaptation impact the amplitude of event-related local field potentials (LFP) in the lateral prefrontal cortex and midcingulate cortex of male rhesus macaques. We found that the behavioral task used induced consistently different types of performance modulation: in relation to task difficulty (imposed by the experimental setup), to successes and errors, and to the time spent in the task. Difficulty had a significant effect on monkeys’ accuracy and reaction times. Interestingly, there is also a strong interaction between difficulty and trial success on the reaction times variation. However, LFP modulations were mostly related to reaction times, touch position, feedback valence and time-in-session, with little, if any, effect of difficulty. Hence difficulty modulated performance but not LFP activity. This suggests that in our experimental design, execution, regulation and motivation-related factors are the main factors influencing medial and lateral frontal activity.Significance Statement:Adapting decisions might be determined by several mechanisms and might be driven by motivational factors and/or factors inherent to the task at hand. Multiple frontal areas contribute to behavioral adaptations. One current challenge is to understand which information they process contributes to behavioral changes. Diverging views have emerged on whether task demands, like the decision difficulty, or factors linked to incentives to adapt, are driving frontal activity. Here we show that task difficulty had a strong effect on performance (accuracy and reaction times) but little effect on LFP recorded in monkey lateral prefrontal and midcingulate cortex. However, information related to actions, outcome valence and time-in-session had major influences. Thus, task difficulty modulated performance but not LFP activity in frontal areas.

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Section: Modulation Of Performance During the Categorization Taskmentioning

confidence: 99%