The Midwest Proton Radiation Institute project at the Indiana University Cyclotron Facility

Anferov, V. A.; Broderick, Brian; Collins, John C.; Friesel, D.L.; Jenner, Dave; Jones, W. P.; Katuin, J.; Klein, Susan Blakeley; Starks, W.; Self, J.; Schreuder, Niek

doi:10.1063/1.1435188

Cited by 4 publications

(4 citation statements)

References 1 publication

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“…The patient positioning system accurately and reproducibly moves the target volume via translation and rotation, so that conformal dose distributions can be achieved with a stationary beam. Fixed‐radiation beams with patient position systems are often used in proton or heavy ion therapy where gantry rotation is impractical or impossible . The same concept can also be applied to x‐ray systems in order to reduce the size, complexity and footprint relative to a conventional rotating gantry linac…”

Section: Introductionmentioning

confidence: 99%

Development and commissioning of a full‐size prototype fixed‐beam radiotherapy system with horizontal patient rotation

et al. 2019

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Purpose Compared to conventional linacs with rotating gantries, a fixed‐beam radiotherapy system could be smaller, more robust and more cost‐effective. In this work, we developed and commissioned a prototype x‐ray radiotherapy system utilizing a fixed vertical radiation beam and horizontal patient rotation. Methods The prototype system consists of an Elekta Synergy linac with gantry fixed at 0° and a custom‐built patient rotation system (PRS). The PRS was designed to immobilize patients and safely rotate them about the horizontal axis. The interlocks and emergency stops of the linac and PRS were connected. Custom software was developed to monitor the system status, control the motion of the PRS and modify treatment plans for the fixed‐beam configuration. Following installation, the prototype system was commissioned for three‐dimensional (3D) conformal therapy based on guidelines specified in AAPM TG‐45 and TG‐142, with modifications for the fixed‐beam geometry made where necessary. Results The system and control software was tested in a variety of machine states and executed motion, stop and beam gating commands as expected. Interlocks and emergency stops of the linac and PRS were found to correctly stop PRS motion and both kV and MV radiation beams when triggered. For 3D conformal treatments, the prototype system met all AAPM TG‐45 and TG‐142 specifications for geometric and dosimetric accuracy. Motion of the PRS was within 0.6 ± 0.3 mm and 0.10° ± 0.07° of input values for translation and rotation respectively. The axis of rotation of the PRS was coincident with the radiation beam axis to less than 1 mm. End‐to‐end treatment verification for 6 MV conformal treatments showed less than 2% difference between planned and delivered dose for all fields. Conclusion In this work, we have developed and commissioned a radiotherapy system that utilizes a fixed vertical radiation beam and horizontal patient rotation. This system is a proof‐of‐concept prototype for a fixed‐beam treatment system without a rotating gantry. Fixed‐beam systems that are smaller and more cost‐effective could help in improving global access to radiotherapy.

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Section: Introductionmentioning

confidence: 99%

Development and commissioning of a full‐size prototype fixed‐beam radiotherapy system with horizontal patient rotation

et al. 2019

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“…Two of the treatment rooms include isocentric gantries with a new uniform beam scanning dose delivery system (1) . The other treatment room uses a traditional Fixed Horizontal Beam Line (FHBL) with a double passive scattering system and fixed range modulator (2) , (3) , (4) . That beamline is similar to other passive systems currently in clinical use (5) , (6) .…”

Section: Methodsmentioning

confidence: 99%

Validation of dosimetric field matching accuracy from proton therapy using a robotic patient positioning system

Farr¹,

O’Ryan-Blair²,

Jesseph³

et al. 2010

J Applied Clin Med Phys

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Large area, shallow fields are well suited to proton therapy. However, due to beam production limitations, such volumes typically require multiple matched fields. This is problematic due to the relatively narrow beam penumbra at shallow depths compared to electron and photon beams. Therefore, highly accurate dose planning and delivery is required. As the dose delivery includes shifting the patient for matched fields, accuracy at the 1–2 millimeter level in patient positioning is also required. This study investigates the dosimetric accuracy of such proton field matching by an innovative robotic patient positioner system (RPPS). The dosimetric comparisons were made between treatment planning system calculations, radiographic film and ionization chamber measurements. The results indicated good agreement amongst the methods and suggest that proton field matching by a RPPS is accurate and efficient.PACS number: 87.55.km

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“…[17][18][19] The beamline is similar to many other passive systems currently in clinical use. [17][18][19] The beamline is similar to many other passive systems currently in clinical use.…”

Section: Treatment Facility and Equipmentmentioning

confidence: 99%

“…The proton therapy equipment available at Midwest Proton Radiotherapy Institute i in 2004 consisted of a nominal 208 MeV proton beam in a single fixed horizontal beamline (FHBL) room, with the beam using a double passive scattering system and fixed range modulator. [17][18][19] The beamline is similar to many other passive systems currently in clinical use. 20,21 The FHBL room takes advantage of a novel robotic patient-positioner system (PPS) that was built by an industrial robot (Motoman Model UP200, Motoman Inc., Miamisburg, OH, USA) 22 having a specified accuracy of 300μm when transiting a payload of up to 200 kg.…”

Section: Treatment Facility and Equipmentmentioning

confidence: 99%

Granulomatous slack skin disease: a new combined proton and photon therapy approach with a reported case response

et al. 2014

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Purpose: Here, we report the feasibility and long-term efficacy of a granulomatous slack skin disease (GSSD) treatment with combined high-energy photon and proton beams.Patient and methods: A GSSD patient with abdominal disease volume 25 × 15 × 2-4 cm deep was recommended for treatment at this institution. In addition to photons and electrons, high-energy protons delivered with advanced planning techniques and patient positioning were used. The patient was irradiated to a total dose of 40 Gy by using 20 Gy matched photon and electrons followed by 20 Gy equivalent protons delivered by using innovative range compensation and patient positioning. Results:The test patient tolerated the treatment well and is now a 10-year survivor of the disease.Conclusions: Treatment of GSSD with protons is feasible. The range and narrow penumbra properties of the proton beam provided an ideal capability to match fields accurately to cover large volumes while also sparing underlying normal tissues.

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The Midwest Proton Radiation Institute project at the Indiana University Cyclotron Facility

Cited by 4 publications

References 1 publication

Development and commissioning of a full‐size prototype fixed‐beam radiotherapy system with horizontal patient rotation

Development and commissioning of a full‐size prototype fixed‐beam radiotherapy system with horizontal patient rotation

Validation of dosimetric field matching accuracy from proton therapy using a robotic patient positioning system

Granulomatous slack skin disease: a new combined proton and photon therapy approach with a reported case response

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