The Migrating Motor Complex

Vantrappen, Gaston; Janssens, Jozef; Peeters, Theo

doi:10.1016/s0025-7125(16)31474-2

Cited by 27 publications

(9 citation statements)

References 43 publications

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“…) (Szurszewski, 1969) which is characterized by periods of intense contractile activity interrupted by periods of quiescence, the whole complex lasting between 1 and 2 h (see Vantrappen, 1982). Anaesthetized animals fail to show this pattern and although the reasons for this are not known they must, in some way, involve the removal of a controlling influence.…”

Section: Introductionmentioning

confidence: 99%

Vagal influences on the jejunal ‘minute rhythm’ in the anaesthetized ferret.

Collman¹,

Grundy²,

Scratcherd³

1983

The Journal of Physiology

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SUMMARY1. Spontaneous jejunal motility in the urethane-anaesthetized ferret shows a cyclical pattern of contraction bursts alternating with quiescent periods described as ' minute rhythm' in conscious animals.2. Cooling the cervical vagi to below 4 'C or acute vagotomy abolished this pattern of motility.3. On re-warming the vagi there was a return to cyclical motility after a latency which depended upon the contractile state at the time vagal conduction was restored.4. Electrical vagal stimulation produced bursts of contractions at the same frequency as the spontaneous motility. Longer periods of stimulation gave rise to bursts of contractions interrupted by periods of relative quiescence, mimicking the spontaneous motility, despite the continuous stimulation.5. Following atropinization all spontaneous motility was abolished, but electrical stimulation of the vagi revealed a non-cholinergic, non-adrenergic response whose characteristics differed from that of the cholinergic response.6. It is concluded that the vagus plays a permissive role in regulating the jejunal 'minute rhythm' via a cholinergic pathway and that there is a second excitatory vagal pathway which innervates non-cholinergic post-ganglionic neurones whose functional significance and transmitter mechanism is unknown.

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Section: Introductionmentioning

confidence: 99%

Vagal influences on the jejunal ‘minute rhythm’ in the anaesthetized ferret.

Collman¹,

Grundy²,

Scratcherd³

1983

The Journal of Physiology

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“…In the Billroth II group the interdigestive migrating motor complex (IMMC) showed a higher relative duration of phase II activity than the controls and a shorter mean time-interval than the controls between subsequent activity fronts, with abnormal jeju nal propagation. These findings indicate that the distal two-thirds of the stomach are neces sary for the inhibitory mechanism, which in normal conditions slow down the idiointestinal interdigestive motor activity to the level of that of the stomach, and suggest that some post gastrectomy syndromes, such as diarrhoea, may have their pathological basis in this hyperac tive intestinal IMMC.It is well known that the interdigestive migrating motor complex (IMMC) [1] starts every 1-2 h from the cardias and propagates through the stomach to the duodenum and the remaining small intestine, keeping the gut lumen clean [2,3] (fig. 1).…”

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confidence: 99%

Effect of Billroth II Operation on the Intestinal Interdigestive Motor Activity

Bortolotti¹,

Bersani²,

Labò³

1985

Digestion

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The interdigestive motor activity of the gastric remnant and the efferent jejunal loop was studied manometrically in 10 patients who underwent Billroth II operation for duodenal ulcer. Two groups, one of 9 normal subjects and the other of 7 duodenal ulcer patients, were used as controls. In the Billroth II group the interdigestive migrating motor complex (IMMC) showed a higher relative duration of phase II activity than the controls and a shorter mean time-interval than the controls between subsequent activity fronts, with abnormal jejunal propagation. These findings indicate that the distal two-thirds of the stomach are necessary for the inhibitory mechanism, which in normal conditions slow down the idiointestinal interdigestive motor activity to the level of that of the stomach, and suggest that some post-gastrectomy syndromes, such as diarrhoea, may have their pathological basis in this hyperactive intestinal IMMC.

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“…He concluded that IAP measured by BP was the most reliable method. Other disadvantages of gastric pressure measurement using a water column as a medium for pressure measurement are that the pressure tends to fluctuate during migrating motor complexes [20,21], it cannot be used during enteral feeding by a nasogastric tube, and it is relatively costly. Gastric pressure measurement by a catheter with an inflated balloon at the tip, as suggested by Spiegelberg, does not have the disadvantages mentioned above, but it does have the advantages of continuity and simplicity.…”

Section: Discussionmentioning

confidence: 99%