The mineral alum: an effective and low-cost heterogeneous catalyst for the successful synthesis of 5-substituted-1 H -tetrazoles

Tetrazole: A privileged scaffold for the discovery of anticancer agents

“…Advantages of this procedure was high yield, safe catalyst, and short reaction time. The product 5-substituted-1H-tetrazole derivatives 80%-100% were also synthesized using Alum NPs as a catalyst in DMSO at 140°C (Scheme 9; Karimian et al, 2021).…”

Construction of a Dual-Functionalized Acid–Base Nanocatalyst via HEPES Buffer Functionalized on Fe3O4 as a Reusable Catalyst for Annulation Reactions

“…Moreover, it can be converted to interesting heterocyclic compounds, especially in drug research . Among these, 2-amino-3-cyano-4 H -chromenes and pyrano­[2,3- c ]­pyrazoles have gained significant attention due to their promising biological properties. − Due to their unique chemical structure and reactivity, these compounds are attractive targets for drug discovery and development. , In addition, several approaches for synthesizing these compounds have been documented, such as the use of homogeneous catalysts. ,,− Current methods for synthesizing these compounds often have limitations, such as elevated temperature, extended reaction times, insufficient product yields, harsh conditions, difficulty in obtaining materials, and complicated postreaction steps. Thus, herein, an efficient protocol is proposed for the synthesis of these fused heterocycles in excellent yields by using a novel heterogeneous method.…”