The mineralized collagen for the reconstruction of intra-articular calcaneal fractures with trabecular defects

Lian, Kai; Lu, Hongzhou; Guo, Xiaodong; Cui, Fuzhai; Qiu, Zhiye; Xu, Shuyun

doi:10.4161/biom.27250

Cited by 41 publications

(38 citation statements)

References 30 publications

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“…The difference in new bone formation may be due to differences in the nanostructures of IMC and EMC. Unlike EMC, which is fabricated by a conventional crystallization method and lacks a surface chemistry and nanostructure similar to that of bone extracellular matrix (Hu et al, ; Liu et al, ), IMC is fabricated via a biomimetic strategy to achieve properties that mimic those of native bone (Feng et al, ; Lian et al, ; Liao et al, ; Qiu et al, ). IMC can promote nutrient transport, blood vessel ingrowth, and osteogenic cell migration throughout the scaffold (Liao et al, ; Liu et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…The EMC can only produce similar chemical properties but not the surface chemistry and nanostructure of bone extracellular matrix; therefore, the strength of EMC is insufficient. Intrafibrillar mineralization (IMC) has been shown to be a predominant factor to the biomechanics of natural bone, and thus, synthesis of mineralized collagen with intrafibrillar HA is recognized as a crucial factor for imitating bone extracellular matrix (Feng et al, ; Fu et al, ; Lian et al, ; Liu et al, ; Qiu et al, ; Xu et al, ; Zhang et al, ). We have previously reported on the fabrication of hierarchical, intrafibrillarly mineralized collagen with distinct nanostructures mimicking the natural bone for use in bone tissue engineering according to the principle of a biomimetic strategy (Feng et al, ; Lian et al, ; Liao, Cui, Zhang, & Feng, ; Xu et al, ; Zhang et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…Intrafibrillar mineralization (IMC) has been shown to be a predominant factor to the biomechanics of natural bone, and thus, synthesis of mineralized collagen with intrafibrillar HA is recognized as a crucial factor for imitating bone extracellular matrix (Feng et al, ; Fu et al, ; Lian et al, ; Liu et al, ; Qiu et al, ; Xu et al, ; Zhang et al, ). We have previously reported on the fabrication of hierarchical, intrafibrillarly mineralized collagen with distinct nanostructures mimicking the natural bone for use in bone tissue engineering according to the principle of a biomimetic strategy (Feng et al, ; Lian et al, ; Liao, Cui, Zhang, & Feng, ; Xu et al, ; Zhang et al, ). IMC materials have shown impressive promoting effects on osteogenic differentiation and bone regeneration both in vitro and in vivo in studies by our group and others (Feng et al, ; Fu et al, ; Lian et al, ; Liu et al, ; Qiu et al, ; Xu et al, ; Zhang et al, ), suggesting that IMC may be an ideal bone scaffold material in bone tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

“…We have previously reported on the fabrication of hierarchical, intrafibrillarly mineralized collagen with distinct nanostructures mimicking the natural bone for use in bone tissue engineering according to the principle of a biomimetic strategy (Feng et al, ; Lian et al, ; Liao, Cui, Zhang, & Feng, ; Xu et al, ; Zhang et al, ). IMC materials have shown impressive promoting effects on osteogenic differentiation and bone regeneration both in vitro and in vivo in studies by our group and others (Feng et al, ; Fu et al, ; Lian et al, ; Liu et al, ; Qiu et al, ; Xu et al, ; Zhang et al, ), suggesting that IMC may be an ideal bone scaffold material in bone tissue engineering. Therefore, we propose that the use of IMC with a titanium (Ti) implant placed simultaneously may be a promising strategy for jawbone defect reconstruction that avoids the donor site morbidity associated with the use of autografts and provides immediate improvement in dental function.…”

Section: Introductionmentioning

confidence: 99%

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Osseointegration effect of biomimetic intrafibrillarly mineralized collagen applied simultaneously with titanium implant: A pilot in vivo study

Zhang

et al. 2019

Clinical Oral Implants Res

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Objectives To investigate the promoting effects of biomimetic intrafibrillarly mineralized collagen (IMC) bone scaffold material on the osseointegration of a titanium implant simultaneously grafted into a critical‐sized bone defect as well as the underlying mechanisms involved. Materials and Methods A critical‐sized bone defect was created in the rat femur, and a titanium (Ti) implant surrounded by IMC or extrafibrillarly mineralized collagen (EMC) bone scaffold material was placed in the defect. A blank group and a natural bone group were included as controls. Osseointegration was assessed by micro‐computed tomographic, histological, and biochemical evaluations at 12 weeks postoperatively. Microarray technology was applied for transcriptional profile analysis at days 7 and 14 postoperatively. Results Significant bone regeneration and osseointegration were observed in the IMC and EMC groups according to μ‐CT and histological analyses. The bone volume (BV)/total volume (TV) fraction, bone‐to‐implant contact percentage, and bone area percentage as well as ultimate shear strength and maximal pull‐out force were all significantly higher in the IMC group than in the EMC group (all p < 0.05). Transcriptional analysis revealed overexpression of genes mainly associated with cell proliferation, immuno‐inflammatory response, skeletogenesis, angiogenesis, neurogenesis, and skeletogenesis‐related pathways during the early process of osseointegration in the IMC group. Conclusion Our data suggest that IMC placed simultaneously with a Ti implant may be a promising strategy in jawbone defect reconstruction. Several candidate genes that were found to be differentially expressed in the IMC group may be responsible for the superior osseointegration effects in this model.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Osseointegration effect of biomimetic intrafibrillarly mineralized collagen applied simultaneously with titanium implant: A pilot in vivo study

Zhang

et al. 2019

Clinical Oral Implants Res

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“…Collagen fibers in the MC assembled in order and served as the templates for the nucleation and growth of the HA crystals [14]. The effects of the MC on repairing bone defects and promoting new bone regeneration have been demonstrated in many animal models and clinical practices, such as the treatments of intervertebral fusion and bone nonunion [15–19]. …”

Section: Introductionmentioning

confidence: 99%

Comparison of rabbit rib defect regeneration with and without graft

Liu

Wang

Zhang

et al. 2016

J Mater Sci: Mater Med

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Rib segment, as one of the most widely used autologous boneresources for bone repair, is commonly isolated with an empty left in the defect. Although defective rib repair is thought to be unnecessary traditionally, it’s of vital importance actually to promote rib regeneration for patients with better postoperative recovery and higher life quality. Comparative investigations on rabbit rib bone regeneration with and without graft were reported in this article. A segmental defect was performed on the 8th rib of 4-month-old male New Zealand rabbits. The mineralized collagen bone graft (MC) was implanted into the defect and evaluated for up to 12 weeks. The rib bone repair was investigated by using X-ray at 4, 8 and 12 weeks and histological examinations at 12 weeks after surgery, which showed a higher bone remodeling activity in the groups with MC implantation in comparison with blank control group, especially at the early stage of remodeling.

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Cell‐Laden Gradient Microgel Suspensions for Spatial Control of Differentiation During Biofabrication

Molley

Hung

Kilian

2022

Adv Healthcare Materials

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During tissue development, stem and progenitor cells form functional tissue with high cellular diversity and intricate micro-and macro-architecture. Current approaches have attempted to replicate this process with materials cues or through spontaneous cell self-organization. However, cell-directed and materials-directed organization are required simultaneously to achieve biomimetic structure and function. Here, it is shown how integrating live adipose derived stem cells with gradient microgel suspensions steers divergent differentiation outcomes. Microgel matrices composed of small particles are found to promote adipogenic differentiation, while larger particles fostered increased cell spreading and osteogenic differentiation. Tuning the matrix formulation demonstrates that early cell adhesion and spreading dictate differentiation outcome. Combining small and large microgels into gradients spatially directs proliferation and differentiation over time. After 21 days of culture, osteogenic conditions foster significant mineralization within the individual microgels, thereby providing cell-directed changes in composition and mechanics within the gradient porous scaffold. Freeform printing of high-density cell suspensions is performed across these gradients to demonstrate the potential for hierarchical tissue biofabrication. Interstitial porosity influences cell expansion from the print and microgel size guides spatial differentiation, thereby providing scope to fabricate tissue gradients at multiple scales through integrated and printed cell populations.

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The mineralized collagen for the reconstruction of intra-articular calcaneal fractures with trabecular defects

Abstract: S. The mineralized collagen for the reconstruction of intra-articular calcaneal fractures with trabecular defects.

Cited by 41 publications

References 30 publications

Osseointegration effect of biomimetic intrafibrillarly mineralized collagen applied simultaneously with titanium implant: A pilot in vivo study

Osseointegration effect of biomimetic intrafibrillarly mineralized collagen applied simultaneously with titanium implant: A pilot in vivo study

Comparison of rabbit rib defect regeneration with and without graft

Cell‐Laden Gradient Microgel Suspensions for Spatial Control of Differentiation During Biofabrication

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