The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of silver nanoparticles against <i>Staphylococcus aureus</i>

Parvekar, Prashik; Palaskar, Jayant; Metgud, Sandeep; Maria, Rahul; Dutta, Smita D

doi:10.1080/26415275.2020.1796674

Cited by 262 publications

(174 citation statements)

References 32 publications

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“…The IONPURE IPL powder showed low antimicrobial activity against S. enterica, requiring relatively high concentrations to inhibit growth in a liquid medium (MIC 0.8-1.6 mg/mL) and to reduce microbial growth in the Petri dishes (MBC 1.6-3.2 mg/mL). Similar results were reported in other researches involving silver nanoparticles against Staphylococcus aureus (S. aureus) [32], with MIC and MBC values of 0.625 mg/mL, or IONPURE IPL against Streptococcus mutans (S. mutans) [33], finding an MIC of 7.5 mg/mL. Such high concentrations can be explained by the fact that the antibacterial powders can be gradually deposited at the bottom of the dishes due to its limited solubility, which cannot be completely avoided even when shaking.…”

Section: Antimicrobial Activity Of Silver Powdersupporting

confidence: 91%

Evaluation of New Antimicrobial Materials Incorporating Ethyl Lauroyl Arginate or Silver into Different Matrices, and Their Safety in Use as Potential Packaging

et al. 2021

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A big challenge for today’s industry is antimicrobial preservation and the safety of food. An effective solution to this problem can be a modern invention such as antimicrobial packaging. In the presented research the antimicrobial activity of two new active films incorporating silver, as IONPURE IPL, and ethyl lauroyl arginate (LAE) were evaluated, by employing a low-density polyethylene (LDPE) matrix and a biofilm material, respectively. Additionally, LAE was also incorporated into polystyrene (PS) pads by two different methods: by spraying and by immersion of the PS pads into an aqueous LAE solution. LDPE films containing silver did not show any antimicrobial activity against Escherichia coli and Aspergillus flavus, whereas the biofilm containing LAE reduced the growth of Salmonella enterica but did not inhibit Aspergillus flavus. The active PS pads, both sprayed and immersed in LAE solution, also showed antimicrobial activity, causing a reduction of 99.99% of Pseudomonas putida growth. Thermal treatment at 180 °C for 6 and 15 min did not modify the antimicrobial activity of LAE against Salmonella enterica. Moreover, inductively coupled plasma-mass spectrometry (ICP-MS) analysis was performed to check the migration of silver from developed material intended for food packaging applications into food simulant.

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Section: Antimicrobial Activity Of Silver Powdersupporting

confidence: 91%

Evaluation of New Antimicrobial Materials Incorporating Ethyl Lauroyl Arginate or Silver into Different Matrices, and Their Safety in Use as Potential Packaging

et al. 2021

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“…Our AgNPs showed significant antimicrobial activity against the Gram-negative bacteria E. coli and P. aeruginosa at low concentrations. In contrast, the Gram-positive bacteria S. epidermidis and S. aureus were observed to be less sensitive 46 . This major difference in antibacterial effects against these two bacteria could be attributed to differences in bacterial surfaces.…”

Section: Discussionmentioning

confidence: 87%

Silver nanoparticles produced from Cedecea sp. exhibit antibiofilm activity and remarkable stability

Singh

Pandit

Jers

et al. 2021

Sci Rep

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With multidrug-resistant bacterial pathogens on the rise, there is a strong research focus on alternative antibacterial treatments that could replace or complement classical antibiotics. Metallic nanoparticles, and in particular silver nanoparticles (AgNPs), have been shown to kill bacterial biofilms effectively, but their chemical synthesis often involves environmentally unfriendly by-products. Recent studies have shown that microbial and plant extracts can be used for the environmentally friendly synthesis of AgNPs. Herein we report a procedure for producing AgNPs using a putative Cedecea sp. strain isolated from soil. The isolated bacterial strain showed a remarkable potential for producing spherical, crystalline and stable AgNPs characterized by UV–visible spectroscopy, transmission electron microscopy, dynamic light scattering, and Fourier transform infrared spectroscopy. The concentration of produced nanoparticles was 1.31 µg/µl with a negative surface charge of − 15.3 mV and nanoparticles size ranging from 10–40 nm. The AgNPs was tested against four pathogenic microorganisms S. epidermidis, S. aureus, E. coli and P. aeruginosa. The nanoparticles exhibited strong minimum inhibitory concentration (MIC) values of 12.5 and 6.25 µg/µl and minimum bactericidal concentration (MBC) values of 12.5 and 12.5 µg/mL against E. coli and P. aeruginosa, respectively. One distinguishing feature of AgNPs produced by Cedecea sp. extracts is their extreme stability. Inductively coupled plasma mass spectrometry and thermogravimetric analysis demonstrated that the produced AgNPs are stable for periods exceeding one year. This means that their strong antibacterial effects, demonstrated against E. coli and P. aeruginosa biofilms, can be expected to persist during extended periods.

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“…The minimal bactericidal concentration (MBC) was determined as described by Parvekar et al [ 76 ]. After a MIC evaluation of the novel compounds and ampicillin, aliquots of 100 µL were taken from tubes without growth and plated on TSA.…”

Section: Methodsmentioning

confidence: 99%

Synthesis and Antibacterial Activity of New Azole, Diazole and Triazole Derivatives Based on p-Aminobenzoic Acid

Sapijanskaitė-Banevič

Palskys

Vaickelionienė

et al. 2021

Molecules

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The p-aminobenzoic acid was applied for the synthesis of substituted 1-phenyl-5-oxopyrrolidine derivatives containing benzimidazole, azole, oxadiazole, triazole, dihydrazone, and dithiosemicarbazide moieties in the structure. All the obtained compounds were evaluated for their in vitro antimicrobial activity against Staphylococcus aureus, Bacillus cereus, Listeria monocytogenes, Salmonella enteritidis, Escherichia coli, and Pseudomonas aeruginosa by using MIC and MBC assays. This study showed a good bactericidal activity of γ-amino acid and benzimidazoles derivatives. The antimicrobial activity of the most promising compounds was higher than ampicillin. Furthermore, two benzimidazoles demonstrated good antimicrobial activity against L. monocytogenes (MIC 15.62 µg/mL) that was four times more potent than ampicillin (MIC 65 µg/mL). Further studies are needed to better understand the mechanism of the antimicrobial activity as well as to generate antimicrobial compounds based on the 1-phenyl-5-oxopyrrolidine scaffold.

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The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of silver nanoparticles against Staphylococcus aureus

Cited by 262 publications

References 32 publications

Evaluation of New Antimicrobial Materials Incorporating Ethyl Lauroyl Arginate or Silver into Different Matrices, and Their Safety in Use as Potential Packaging

Evaluation of New Antimicrobial Materials Incorporating Ethyl Lauroyl Arginate or Silver into Different Matrices, and Their Safety in Use as Potential Packaging

Silver nanoparticles produced from Cedecea sp. exhibit antibiofilm activity and remarkable stability

Synthesis and Antibacterial Activity of New Azole, Diazole and Triazole Derivatives Based on p-Aminobenzoic Acid

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