The Minimum Killing Concentrations of Chlorhexidine Gluconate and Olanexidine Gluconate on Clinically Isolated &lt;i&gt;S.aureus&lt;/i&gt; Strains

Nakazawa, Yozo; Tamura, Taku; Hori, Seiji

doi:10.4058/jsei.33.52

Cited by 3 publications

(6 citation statements)

References 7 publications

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“…Nine studies validated the spectrum: seven for bacteria and fungi 20 , 21 , 22 , 23 , 24 , 25 , 28 and four for viruses. 28 , 32 , 33 , 34 Several studies 20 , 23 , 25 , 28 used the minimum bactericidal concentration (MBC) at which bacterial growth did not occur as an indicator of the bactericidal effect of skin disinfectants.…”

Section: Resultsmentioning

confidence: 99%

“…For MRSA, two studies showed that 1.5% OLG was more effective for disinfection than 0.5% CHG and 10% PVP‐I (Table 3 ). 22 , 25 In addition, two studies 20 , 24 compared whether the MBC of OLG, CHG, and PVP‐I changed in the presence or absence of qacA/B , which encodes a disinfectant efflux pump thought to be responsible for methicillin resistance. The researchers reported that only the MBC of OLG remained unchanged in the presence or absence of qacA/B (Table 3 ).…”

Section: Resultsmentioning

confidence: 99%

“…In vitro, OLG has a broad‐spectrum, disinfecting, and fast‐acting activity against drug‐resistant bacteria. 20 , 21 , 22 , 23 , 24 , 25 …”

Section: Introductionmentioning

confidence: 99%

“…To prevent SSIs and CRBSIs caused by bacteria resistant to CHG and PVP‐I, olanexidine [1‐(3,4‐dichlorobenzyl)‐5‐octylbiguanide] gluconate (OLG) was developed in Japan in 2015. In vitro, OLG has a broad‐spectrum, disinfecting, and fast‐acting activity against drug‐resistant bacteria 20–25 …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Clinical application of skin antisepsis using aqueous olanexidine: a scoping review

Shinzato

Sakihara

Kishihara

et al. 2022

Acute Medicine & Surgery

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Surgical site infections (SSIs) and catheter‐related bloodstream infections (CRBSIs) caused by bacteria from surfaces poorly disinfected with chlorhexidine gluconate (CHG) and povidone‐iodine (PVP‐I) are increasing. Olanexidine gluconate (OLG) was developed in 2015 in Japan to prevent SSI and CRBSI caused by bacteria resistant to CHG and PVP‐I. This scoping review aimed to identify the knowledge gap between what is known and what is not known about the disinfection efficacy of OLG. We searched MEDLINE through PubMed, the Cochrane Central Register of Controlled Trials, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), the International Clinical Trials Registry Platform search database, ClinicalTrials.gov , and the Web‐based database of Japanese medical articles for works published to July 18, 2021. Manual reference searches were also carried out. A total of 131 studies were screened. Forty‐seven studies were included in this review and classified into two major categories: studies on pharmacological effects and spectrum ( n = 29) and studies on clinical and adverse effects ( n = 18). Olanexidine gluconate showed bactericidal activity against methicillin‐resistant Staphylococcus aureus and vancomycin‐resistant enterococci, in addition to common Gram‐positive and Gram‐negative bacteria. In clinical settings, although there is limited evidence on SSI prevention, 1.5% OLG might be more effective than 10% PVP‐I and 1% CHG in preventing SSI. However, the clinical usefulness of OLG is unclear due to the limited number of clinical studies. Also, clinical research is limited to studies targeting SSI prevention, and there are no clinical studies on CRBSI. Further clinical studies are needed on SSI and CRBSI prevention.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…In vitro, OLG has a broad‐spectrum, disinfecting, and fast‐acting activity against drug‐resistant bacteria. 20 , 21 , 22 , 23 , 24 , 25 …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical application of skin antisepsis using aqueous olanexidine: a scoping review

Shinzato

Sakihara

Kishihara

et al. 2022

Acute Medicine & Surgery

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“…Safety for corneal endothelial cells and retina has not been studied. The 90% minimum killing concentration (MKC 90 ) against S. aureus is 0.5% and MKC 50 is 0.125% [57]. At the concentration range of 0.05-0.1% used for mucous membrane disinfection, the bactericidal effect on S. aureus is mild.…”

Section: Povidone-iodine As a "Border Control" Measurementioning

confidence: 99%

Cataract Surgery by Intraoperative Surface Irrigation with 0.25% Povidone–Iodine

Shimada

Nakashizuka

2021

JCM

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Postoperative endophthalmitis after cataract surgery is typically caused by the patient’s own conjunctival normal bacterial flora. A three-step approach is recommended to prevent endophthalmitis: (1) “border control” to prevent microorganisms from entering the eye by disinfecting the ocular surface is the most important measure; (2) bacteria that have gained access into the anterior chamber are reduced by irrigation; (3) bacteria remaining in the anterior chamber and vitreous at the end of surgery are controlled by antibacterial drugs. We have devised a method, “the Shimada technique”, for irrigating the ocular surface with povidone-iodine, a disinfectant with potent microbicidal effect and established effective and safe concentrations for eye tissues. Povidone-iodine exhibits a bactericidal effect for a wide concentration range of 0.005–10%, but 0.1% povidone-iodine has the highest activity and requires the shortest time of only 15 s to achieve microbicidal effect. When used to irrigate the ocular surface every 20–30 s during cataract surgery, 0.25% povidone-iodine is conceivably diluted to around 0.1%. Irrigation with 0.25% povidone-iodine during cataract surgery significantly reduced bacteria contamination rate in the anterior chamber compared with saline (p = 0.0017) without causing corneal endothelial damage.

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Fast-acting bactericidal activity of olanexidine gluconate against qacA/B-positive methicillin-resistant Staphylococcus aureus

Nakaminami

Takadama

Okita

et al. 2019

Journal of Medical Microbiology

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The Minimum Killing Concentrations of Chlorhexidine Gluconate and Olanexidine Gluconate on Clinically Isolated <i>S.aureus</i> Strains

Cited by 3 publications

References 7 publications

Clinical application of skin antisepsis using aqueous olanexidine: a scoping review

Clinical application of skin antisepsis using aqueous olanexidine: a scoping review

Cataract Surgery by Intraoperative Surface Irrigation with 0.25% Povidone–Iodine

Fast-acting bactericidal activity of olanexidine gluconate against qacA/B-positive methicillin-resistant Staphylococcus aureus

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