The missing role of diagnosis of confined placental mosaicism in the management of fetal growth restriction

Hantoushzadeh, Sedigheh; Saleh, Maasoumeh; Nouri, Behnaz; Nazari, Farzaneh; Salmani, Tayyebali

doi:10.1093/humupd/dmab032

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…24 In contrast, some researchers have concurred that it would be reasonable to recommend CVS directly for pregnancies with early-onset severe symmetrical FGR < 24 weeks. 39 The disadvantage of this method is that the anomaly and level of mosaicism detected by CVS do not represent the entire condition of the placenta. Meanwhile, when mosaicism is detected in CVS, amniocentesis should also be performed for fetal karyotyping to differentiate CPM from fetal mosaicism concurrently, which may increase the risk of procedure-related pregnancy loss.…”

Section: Confined Placental Mosaicism (Cpm)mentioning

confidence: 99%

“…However, NIPT is just a screening strategy and can only analyze the placental cytotrophoblast, which includes CPM type I and type III, but can not determine CPM type II because it is derived from the mesenchymal core of the chorionic villi 24 . In contrast, some researchers have concurred that it would be reasonable to recommend CVS directly for pregnancies with early-onset severe symmetrical FGR < 24 weeks 39 . The disadvantage of this method is that the anomaly and level of mosaicism detected by CVS do not represent the entire condition of the placenta.…”

Section: Placental Genetic Etiologies For Fgrmentioning

confidence: 99%

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Genetics Etiologies Associated with Fetal Growth Restriction

Shi

Cai

Sun

2022

Maternal-Fetal Medicine

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Fetal growth restriction (FGR) is associated with multiple adverse perinatal outcomes, such as increased risk of intrauterine death, neonatal morbidity and mortality, and long-term adverse outcomes. Genetic etiological factors are critical in fetuses with intrauterine growth restriction, including chromosomal abnormalities, copy number variants, single gene disorders, uniparental disomy, epigenetic changes, and confined placental mosaicism. This paper aims to provide an overview of genetic defects related to FGR and to highlight the importance of prenatal genetic counseling and testing for precise diagnosis and management of FGR.

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Section: Confined Placental Mosaicism (Cpm)mentioning

confidence: 99%

Section: Placental Genetic Etiologies For Fgrmentioning

confidence: 99%