The MMP-8 rs11225395 Promoter Polymorphism Increases Cancer Risk of Non-Asian Populations: Evidence from a Meta-Analysis

Feng, Jiarong; Chen, Yudi; Hua, Wenxi; Sun, Xiaohan; Chen, Yanjie; Liu, Yu; Fan, Jie; Zhao, Yuening; Zhao, Lei; Xu, Xiaojing; Yang, Xiaoqin

doi:10.3390/biom9100570

Cited by 9 publications

(6 citation statements)

References 34 publications

(41 reference statements)

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“…The allelic frequency of the A variant in the general population ranges from 18 to 45%, according to the different populations studied, with the highest prevalence in the European and Mexican populations (available at (accessed on 3 February 2022). This variant has been previously associated with many different conditions such as cancer [ 33 , 34 ], aggressive periodontitis [ 35 ], recurrent pregnancy loss [ 36 ], and inflammation in atherosclerosis [ 32 ]. In all these studies, Hardy–Weinberg was maintained.…”

Section: Discussionmentioning

confidence: 99%

Genetic Variants of Matrix Metalloproteinase and Sepsis: The Need Speed Study

et al. 2022

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Many causal mechanisms in sepsis susceptibility are largely unknown and the functional genetic polymorphisms (GP) of matrix metalloproteinases (MMPs) and their natural tissue inhibitor of MMPs (TIMP1) could play a role in its development. GPs of MMPs and TIMP (namely MMP-1 rs1799750, MMP-3 rs3025058, MMP-8 rs11225395, MMP-9 rs2234681, and TIMP-1 rs4898) have been compared in 1058 patients with suspected sepsis to assess the association with susceptibility and etiology of sepsis. Prevalence of MMP8 rs11225395 G/G genotype was higher in sepsis patients than in those with non-infective Systemic Inflammatory Reaction Syndrome (35.6 vs. 26%, hazard ratio, HR 1.56, 95% C.I. 1.04–2.42, p = 0.032). G/G patients developed less hyperthermia (p = 0.041), even after stratification for disease severity (p = 0.003). Patients carrying the 6A allele in MMP3 rs3025058 had a higher probability of microbiologically-proven sepsis (HR 1.4. 95%C.I. 1.01–1.94, p = 0.044), particularly when due to virus (H.R. 2.14, 95% C.I. 1.06–4.31, p = 0.046), while MMP-1 G/G genotype patients carried a higher risk for intracellular bacteria (Chlamydia, Mycoplasma, and Legionella, H.R. 6.46, 95% C.I. 1.58–26.41, p = 0.003). Neither severity of sepsis at presentation, nor 30-day mortality were influenced by the investigated variants or their haplotype. MMP8 rs11225395 G/G carriers have lower temperature at presentation and a more than 50% increased susceptibility to sepsis. Among patients with sepsis, carriers of MMP1 rs1799750 G/G have an increased susceptibility for intracellular pathogen infections, while virus serology is more often positive in those with the MMP3 rs3025058 A/A genotype.

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Section: Discussionmentioning

confidence: 99%

Genetic Variants of Matrix Metalloproteinase and Sepsis: The Need Speed Study

et al. 2022

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“…In 2019, a meta-analysis was conducted by Feng et al to address the inconsistent results from various studies investigating the association of MMP-8 rs11225395 genotype with different types of cancer, including those mentioned previously. The meta-analysis revealed no association between MMP-8 rs11225395 genotype and overall cancer risk worldwide (30). Based on the current available evidence, it is tentatively concluded that there may be an elevated cancer risk associated with MMP-8 rs11225395 genotype in non-Asian populations, while no association has been found in Asian populations (30).…”

Section: Discussionmentioning

confidence: 92%

Impact of Matrix Metalloproteinase-8 Genotypes on Colorectal Cancer Risk in Taiwan

DENG,

KE,

WANG

et al. 2023

Anticancer Res

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Background/Aim: This study aimed to investigate the involvement of matrix metalloproteinase-8 (MMP-8) genotypes in the development of colorectal cancer (CRC). Materials and Methods: The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to analyze the genotypes of MMP-8 C-799T (rs11225395), Val436Ala (rs34009635), and Lys460Thr (rs35866072) in 362 patients with CRC and 362 controls. Additionally, the potential associations between these genotypes and factors such as age, sex, smoking, alcohol consumption, and body mass index (BMI) status in relation to CRC risk were also assessed. Results: No significant differences in the distribution of MMP-8 rs11225395 genotypes were found between the control and case groups (p for trend=0.3836). Logistic regression analysis demonstrated that individuals with the MMP-8 rs11225395 variant CT and TT genotypes had a 0.83 and 0.77-fold risk of CRC, respectively. Moreover, carriers of the rs11225395 CT+TT genotypes were not associated with CRC risk either (p=0.2063). Furthermore, individuals with the MMP-8 rs11225395 TT genotype exhibited significantly lower odds of CRC risk compared to those with the CC genotype among nonsmokers (p=0.0379). No significant associations were observed with respect to MMP-8 rs34009635 or rs35866072. Conclusion: The analyzed genotypes of MMP-8 play a minor role in determining individual susceptibility to CRC risk.Colorectal cancer (CRC) accounts for approximately 11% of all newly diagnosed cancer cases and is the third most common cancer worldwide, causing the second highest number of cancer-related deaths (1, 2). The pathogenesis of CRC involves various factors that contribute to complex genetic and epigenetic processes, ultimately leading to the transformation of normal colonic mucosa into cancerous tissue (3). Numerous molecular signaling networks implicated in CRC initiation and progression have been reported in the literature, including the ERK/MAPK, TGFβ, PI3K/Akt, Src/FAK, and β-catenin related signal transduction pathways. These pathways are associated with the hallmarks of cancer, such as inflammation, angiogenesis, metastasis, and invasion. Notably, activation and over-expression of matrix metalloproteinases (MMPs) have been linked to these signal transduction pathways, making MMPs potential prognostic factors for CRC (4, 5). Thus, MMPs have been suggested to be potential prognostic factors for CRC. 3979

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“…More recently, it has been shown (7,18) that specific polymorphisms in the MMP-9 and TIMP-2 genes potentially increase the risk of developing varicose veins in patients. Vein remodeling and associated gene expression were also studied, but the results did not correlate with the development and severity of PTS [5,12].…”

Section: Research Results and Discussionmentioning

confidence: 99%

The Role of Genetic Polymorphism in the Pathogenesis of Chronic Venous Insufficiency

E.A.¹

2022

ijcsrr

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Chronic venous diseases (CVD), including varicose veins, are among the most common diseases in developed countries in Europe and the United States and affect one third to one half of the population, especially women. Among many achievements in the knowledge of the pathogenesis of achievements, it should be noted the identification of the role of matrix metalloproteinases (MMPs) as important mediators of the degenerative process associated with the onset and progression of venous insufficiency. The study included 98 patients aged 20 to 78 years with chronic venous insufficiency, including, in accordance with the CEAP classification, 45 patients with moderate CVI (class C3–C4) and 53 patients with severe CVI (class C5–C6). The results obtained in the course of the study reliably indicate the presence of an association between the carriage of the Arg allele and the Gln/Arg and Arg/Arg genotypes of the Gln279Arg polymorphism in the MMP9 gene with the risk of developing complicated forms of CVI.

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The MMP-8 rs11225395 Promoter Polymorphism Increases Cancer Risk of Non-Asian Populations: Evidence from a Meta-Analysis

Cited by 9 publications

References 34 publications

Genetic Variants of Matrix Metalloproteinase and Sepsis: The Need Speed Study

Genetic Variants of Matrix Metalloproteinase and Sepsis: The Need Speed Study

Impact of Matrix Metalloproteinase-8 Genotypes on Colorectal Cancer Risk in Taiwan

The Role of Genetic Polymorphism in the Pathogenesis of Chronic Venous Insufficiency

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