The MMSE orientation for time domain is a strong predictor of subsequent cognitive decline in the elderly

Guerrero‐Berroa, Elizabeth; Luo, Xiaodong; Schmeidler, James; Rapp, Michael A.; Dahlman, Karen; Grossman, Hillel; Haroutunian, Vahram; Beeri, Michal Schnaider

doi:10.1002/gps.2282

Cited by 93 publications

(62 citation statements)

References 27 publications

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“…MMSE items that emerged as significant predictors of membership in a declining trajectory were similar to those identified in previous studies on predictors of risk for cognitive decline [20,27,31]. However, previous studies analyzed all participants with MCI as if they constituted a homogeneous group, despite ample evidence that they are not [9,10].…”

Section: Discussionsupporting

confidence: 51%

“…Demographic variables such as older age have been associated with a greater rate of decline in MMSE score among people with MCI [26]; however, little is known about clinical predictors of change in cognitive ability. In a study of 505 elderly nursing home residents, orientation to time was found to predict subsequent decline in the total MMSE score [27]. Lower rates of decline were observed in people who scored high on delayed recall plus one of either attention or orientation to place.…”

Section: Introductionmentioning

confidence: 99%

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Predictors of Future Cognitive Decline in Persons with Mild Cognitive Impairment

Xie

Mayo

Koski

2011

Dement Geriatr Cogn Disord

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This study sought first to identify individual items of the Mini-Mental State Examination (MMSE) and demographic variables at baseline that predicted the trajectories of cognitive change among patients with mild cognitive impairment (MCI), and second to quantify the risk of cognitive decline in such patients based on their pattern of failure of MMSE items. 187 MCI patients were evaluated serially with the MMSE for up to 3.5 years. Patients who followed a declining cognitive trajectory differed from the stable reference group in their baseline profile of MMSE test performance. Patient age and performance on delayed recall, constructional praxis, attention, and orientation to time and floor predicted future cognitive decline with good accuracy (79.9%) and specificity (86.4%), and moderate sensitivity (67.2%). These results are presented in the form of a simple clinical tool for quantifying risk of future cognitive decline in MCI.

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Section: Discussionsupporting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Predictors of Future Cognitive Decline in Persons with Mild Cognitive Impairment

Xie

Mayo

Koski

2011

Dement Geriatr Cogn Disord

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“…Cognitive function was measured by the Mini-Mental State Examination (MMSE). (19) Health related quality of life was assessed by the EQ-5D. Negative values of EQ-5D were replaced by zero.…”

Section: Cross-sectional Survey Of Patients Living At Homementioning

confidence: 99%

Costs of dementia in Hungary

Érsek

Kovács

Wimo

et al. 2010

The Journal of nutrition, health and aging

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This is the first study investigating resource utilisation, costs, and quality of life of dementia patients in the Central and Eastern European region. Compared to the general population of Hungary EQ-5D values of the demented patients are lower in all age groups. Dementia related costs are much lower in Hungary compared to Western European countries. There is no remarkable difference between the costs of demented patients living at home and in nursing homes, from the societal point of view.

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“…For example, MMSE orientation to time and delayed recall domains predict rate of decline in patients with prodromal dementia (i.e., mild cognitive impairment) [27] and older adult nursing home residents [28], while MMSE visuoconstruction and orientation to place domains appear most sensitive to predicting falls in elderly patients [29]. Jefferson and colleagues associated Alzheimer’s disease with greater impairment in orientation to time and delayed recall domains, small vessel vascular disease with working memory and visuoconstruction domain deficits, and Parkinson’s disease with errors in sentence writing accuracy [30].…”

Section: Introductionmentioning

confidence: 99%

Delayed Recall and Working Memory MMSE Domains Predict Delirium following Cardiac Surgery

Price

Garvan

Hizel

et al. 2017

JAD

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Background Reduced preoperative cognition is a risk factor for postoperative delirium. The significance for type of preoperative cognitive deficit, however, has yet to be explored and could provide important insights into mechanisms and prediction of delirium. Our goal was to determine if certain cognitive domains from the general cognitive screener- the Mini Mental State Exam (MMSE) - predict delirium after cardiac surgery. Method Patients completed a preoperative MMSE prior to undergoing elective cardiac surgery. Following surgery, delirium was assessed throughout ICU stay using the Confusion Assessment Method for ICU delirium and the Richmond Agitation and Sedation Scale. Results Cardiac surgery patients who developed delirium (n=137) had lower total MMSE scores than patients who did not develop delirium (n=457). In particular, orientation to place, working memory, delayed recall, and language domain scores were lower. Of these, only the working memory and delayed recall domains predicted delirium in a regression model adjusting for history of chronic obstructive pulmonary disease, age, sex, and duration of cardiopulmonary bypass. For each word not recalled on the three-word delayed recall assessment, the odds of delirium increased by 50%. For each item missed on the working memory index, the odds of delirium increased by 36%. Of the patients who developed delirium, 47% had a primary impairment in memory, 21% in working memory, and 33% in both domains. The area under the receiver operating characteristics curve using only the working memory and delayed recall domains was 0.75, compared to 0.76 for total MMSE score. Conclusion Delirium risk is greater for individuals with reduced MMSE scores on the delayed recall and working memory domains. Research should address why patients with memory and executive vulnerabilities are more prone to postoperative delirium than those with other cognitive limitations.

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The MMSE orientation for time domain is a strong predictor of subsequent cognitive decline in the elderly

Cited by 93 publications

References 27 publications

Predictors of Future Cognitive Decline in Persons with Mild Cognitive Impairment

Predictors of Future Cognitive Decline in Persons with Mild Cognitive Impairment

Costs of dementia in Hungary

Delayed Recall and Working Memory MMSE Domains Predict Delirium following Cardiac Surgery

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