The Mn(II), Co(II), Ni(II) and Cu(II) complexes of (Z)-N'((1H-indol-3-yl)methylene)nicotinohydrazide Schiff base: synthesis, characterization and biological evaluation

Neelufar,; Rangaswamy, Javarappa; Ankali, Kariyappa N; Naik, Nagaraja; Nuthan, Bettadapura Rameshgowda; Sardana, Satish

doi:10.1007/s13738-022-02580-1

Cited by 4 publications

(1 citation statement)

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“…Naik and coworkers also reported bi-dentate indol based hydrazone ligand prepared by condensation of nicotinic acid hydrazide and indole-3-carboxaldehyde and their transition metal complexes (Cu(II), Co(II), Mn(II), and Ni(II)) under octahedral geometry for their potential biological activity (Figure 19) [49]. Of the transition metal complexes, copper(II) and cobalt (II) complexes exhibited better antibacterial as well as effective oxidative DNA cleavage activity.…”

Section: Proposed Schematic Structural Representation Of the Metal Co...mentioning

confidence: 99%

Novel Synthesis of N–N Azo and Hydrazine Phenyl Ligand Derivatives for Copper(II) Complex Bio-Active Application

I. Al-Sulami,

G. Ashebr

2024

Copper Overview - From Historical Aspects to Applications

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Copper(II) complexes possess relatively a broad spectrum of medicinal importance with less toxicity. It is important to note that, in this chapter, copper(II) is selected as chelating central metal atom considering its current reputation to design such bio-active compounds due to its; (i) permits in realizing stable coordination compound, (ii) diverse coordinating capability with oxygen (O), nitrogen (N), sulfur (S) and phosphorus (P) donor ligands, and (iii) exhibits potentially better biological activity. Therefore, the presented chapter offers the up-to-date advancement and future perspective of bio-active copper(II) complexes derived from Schiff base of azo- and phenyl hydrazine-based ligands and their derivatives. To showcase the existing trend of these classes of bio-active compounds, due to the wide depth of the literature, selected seminal compounds exhibiting outstanding biological activity are discussed in detail. Recent studies establish that azo- and phenyl hydrazine-based bio-active copper(II) complexes are among the promising candidates that are expected to replace the conventional antibiotics which are suffering from side effects as well as microbial resistance. However, the collaborative efforts of chemists and biotechnologists are still needed to realize their real world application.

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Section: Proposed Schematic Structural Representation Of the Metal Co...mentioning

confidence: 99%