The mobile micro-architecture of dermal collagen: A bio-engineering study

Gibson, T.; Kenedi, R. M.; Craik, J. E.

doi:10.1002/bjs.1800521017

Cited by 140 publications

(78 citation statements)

References 2 publications

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“…In particular, histological evidence from this study in the stress-free state suggests that although the SEF term for collagen may apply to both layers, the use of a neo-Hookean term, relating to the thick elastic lamellae in large arteries, is not validated for esophagus that shows low content especially in the muscle layer (Fan et al, 2005), and non-isotropic appearance of elastin, whose arrangement is largely longitudinal. Nor has a biphasic response been confirmed, with elastin bearing low and collagen high stresses, as done for skin (Gibson et al, 1965) Table 1 Material parameters of the Fung-type strain energy function from experimental pressure-diameter-force data of the mucosa-submucosa and muscle layers.…”

Section: Discussionmentioning

confidence: 97%

Biomechanical and histological characteristics of passive esophagus: Experimental investigation and comparative constitutive modeling

Stavropoulou

Dafalias

Sokolis

2009

Journal of Biomechanics

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Section: Discussionmentioning

confidence: 97%

Biomechanical and histological characteristics of passive esophagus: Experimental investigation and comparative constitutive modeling

Stavropoulou

Dafalias

Sokolis

2009

Journal of Biomechanics

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“…Unwounded skin has already been shown to have a two-phase curve (Gibson, Kenedi, and Craik, 1965). The graph was relatively flat as the collagen fibre then became steeper as the collagen fibres were loaded At 10 days the curves were flatter than normal, tape-closed wound ( P = 0.024).…”

Section: Mechanicalmentioning

confidence: 95%

Tape-closed and sutured wounds: A comparison by tensiometry and scanning electron microscopy

Forrester

Zederfeldt

Hayes

et al. 1970

Journal of British Surgery

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SUMMARYI . The ability of a wound to resist rupture (energy absorption or 'toughness') is calculated from its tensile strength and extension ('give '). This property of the wound is only half that of normal tissue after 5 months of healing.2. A biomechanical study shows that tape-closed wounds develop greater tensile strength than sutured wounds. However, they are more brittle and have, as a result, no greater ability to resist rupture. Other considerations such as obliteration of dead space, prevention of infection, and cosmetic result may therefore be used in choosing between them.3. The rate of collagen synthesis is the same in both wound types. It reaches its peak between 20 and 40 days and returns to normal by 150 days.4. The scanning electron microscope demonstrates how the structure of the wound evolves from random fibril patterns to large collagen masses. Mechanical behaviour can be related to collagen fibre weave and variations in fibre alinement. Differences in organization are observed between tape-closed and sutured wounds and a hypertrophic scar (keloid). 5.The scanning electron microscope appearance of a hypertrophic scar supports the view that its existence may depend on repeated rupturing and rehealing of small fibrils in a brittle scar. 6. It may be possible to control the structural organization of collagen during healing, thus improving ' scar performance ' and making possible the 'cultivation' of collagen shapes and materials for repair purposes.THIS study was prompted by the observation that the apparently well-healed skin wound was remarkably weak at the end of IOO days (Douglas, Forrester, and Ogilvie, 1969).Since local factors play an important part in determining the quality of repair (Halsted, 1913;Whipple, 1940;Sandblom, 1944;Dunphy and Jackson, 1962) we decided to further our investigations by a comparison of tape-closed and suture-closed wounds healing synchronously in the same animal.We adopted this approach because there are indications that tape-closure produces better healing conditions. Suture-closure causes a local inflammatory response (Howes, 1933; Postlethwaite, Schauble, Dillon, and Morgan, 1959) and immobilizes the wound, whereas careful tape-closure reduces inflammation and improves the cosmetic result (Dunphy and Jackson, 1962; Ordman and Gillman, 1966; Conolly, Hunt, Zederfeldt, Cafferata, and Dunphy, 1969). In addition, the exposure to adjacent soft-tissue forces appears to improve the strength of repair (Brunius and Ahrkn, 1969).A further consideration is that strength measurements, although undoubtedly providing valuable information on the healing process, incompletely describe repair. The extension or 'give' is just as important and the mechanical behaviour before rupture is of considerable theoretical and practical significance.Over 500 wounds were examined between 10 and 150 days using a bio-engineering technique previously reported (Forrester, Zederfeldt, and Hunt, 1969). Standard, die-cut specimens of skin and scar were tested to their breaking points. The specim...

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“…The mechanism most responsible for the success of dynamic wound closure is the resultant "mechanical creep"-a biomechanical property of skin that allows it to gradually stretch beyond the limits of its inherent extensibility [24]. This increase in length occurs within minutes and is explained by the straightening of collagen fibers in the direction of the stretching force, until the fibers are parallel and resist further extension [25,26].…”

Section: Discussionmentioning

confidence: 99%

Management of a giant omphalocele with an external skin closure system

Baird

Gholoum

Laberge

et al. 2010

Journal of Pediatric Surgery

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The mobile micro-architecture of dermal collagen: A bio-engineering study

Abstract: 1960), 'Veno-arterial Pumpinf: in Normal Does and Does with Coronarv Occlusion .

Cited by 140 publications

References 2 publications

Biomechanical and histological characteristics of passive esophagus: Experimental investigation and comparative constitutive modeling

Biomechanical and histological characteristics of passive esophagus: Experimental investigation and comparative constitutive modeling

Tape-closed and sutured wounds: A comparison by tensiometry and scanning electron microscopy

Management of a giant omphalocele with an external skin closure system

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