The Mobilization of Free Fatty Acids in Response to Isoprenaline in the Rat

Barrett, A. M.

doi:10.1111/j.1476-5381.1965.tb02072.x

Cited by 17 publications

(8 citation statements)

References 33 publications

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“…In the rat, Stanton (1972) showed that the Plselective agent practolol is a very poor inhibitor of isoprenaline induced rises in plasma free fatty acids, although earlier reports suggested the lipolytic response to various agonists to show a pl-profile (Barrett, 1965;Arnold & McAuliff, 1971). …”

Section: Animal Studiesmentioning

confidence: 99%

Beta‐adrenoceptor blocking agents and lipolysis.

Harms¹,

Vente²,

Zaagsma³

1982

Brit J Clinical Pharma

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1 The pharmacological characteristics of I-adrenoceptor subtypes on adipocytes of various mammalian species, including man, are reviewed. 2 Rat adipocytes possess a homogeneous population of 0-adrenoceptors with properties that clearly distinguish them from 'classic' ,13-and P2-adrenoceptors, although they share certain features with both. Thus, rat adipocyte P-adrenoceptors should be considered as non-pl-non-P2 receptors, like the atypical 1-adrenoceptors found on erythrocytes of turkey, chicken and frog. 3 Preliminary data suggest that adipocyte P-adrenoceptors of guinea pig and swine are different from 'classic' pl-and P2-adrenoceptors as well, whereas in the dog and possibly in the cat, a mixture of Pl-and P2-receptors mediates catecholamine induced lipolysis.

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Section: Animal Studiesmentioning

confidence: 99%

Beta‐adrenoceptor blocking agents and lipolysis.

Harms¹,

Vente²,

Zaagsma³

1982

Brit J Clinical Pharma

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“…However, except for increases in blood glucose, metabolic responses to noradrenaline are only slightly potentiated by cocaine pretreatment and such potentiation requires doses of cocaine greater than those necessary to potentiate other noradrenaline responses such as vasoconstriction (Hardman & Mayer, 1965). Furthermore, neuronal uptake inactivation does not explain the relatively strong activity of noradrenaline compared to other catecholamines in producing increases in plasma FFA (Barrett, 1965). In general, studies with noradrenaline and other selective agonists appear to support the concept that metabolic adrenoceptors are heterogeneous and are differentiated into subtypes.…”

Section: Discussionmentioning

confidence: 75%

“…On the other hand, elevation of blood lactate or glucose may diminish increases in plasma FFA due to stimulation of lipolytic adrenoceptors by facilitating re-esterification to triglycerides (Miller et al, 1964 (Hardman & Mayer, 1965). Furthermore, neuronal uptake inactivation does not explain the relatively strong activity of noradrenaline compared to other catecholamines in producing increases in plasma FFA (Barrett, 1965 (Cash, Woodfield & Allan, 1970) and therefore blockade of the 'cardiac' padrenoceptor subtype is problematical. Butoxamine, an antagonist which selectively antagonizes isoprenaline-induced vasodilatation (Parratt & Wadsworth, 1970), also antagonizes isoprenalineinduced increases in glucose and lactate (Salvadore, April & Lemberger, 1966).…”

Section: Discussionmentioning

confidence: 99%

Differentiation of Metabolic Adrenoceptors

Loakpradit

Lockwood

1977

British J Pharmacology

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Cardiovascular and metabolic responses to intravenous infusion of isoprenaline were measured in fasted, anaesthetized cats. Isoprenaline (0.2 μg kg−1 min−1 for 15 min) decreased diastolic blood pressure and increased heart rate, blood glucose, blood lactate and plasma free fatty acids. Oxprenolol (0.5 mg/kg) antagonized all cardiovascular and metabolic effects of isoprenaline non‐selectively. Para‐oxprenolol (0.25 mg/kg) and practolol (4 mg/kg) antagonized the effects of isoprenaline on heart rate and free fatty acids selectively. H 35/25 ((1‐(4‐methylphenyl)‐2‐isopropyl aminopropanol) hydrochloride, 3 mg/kg) antagonized the effects of isoprenaline on blood pressure, glucose and lactate selectively. It is concluded that metabolic adrenoceptors are differentiated into subtypes similar to those mediating cardiostimulation and vasodilatation.

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“…It has been used successfully to control arrhythmias during operative removal of a -haeochromocytoma (Riddell et al, 1963). Pronethalol has only slight sympathomimetic activity (Barrett, 1965) and has been demonstrated to be an effective /3-blocking agent in animals (Black and Stephenson, 1962 ;Black, Duncan, and Shanks, 1965) and in man (Dornhorst and Robinson, 1962). It has unfortunately been incriminated as a carcinogen in mice, producing thymic and other tumours (Paget, 1963), and has now been withdrawn.…”

Section: Blood Pressure After Removal Of the Tumourmentioning

confidence: 99%