The modulation of B7.2 and B7.1 on B cells by immunosuppressive agents

Jirapongsananuruk, Orathai; Leung, Donald Y.M.

doi:10.1046/j.1365-2249.1999.01028.x

Cited by 62 publications

(9 citation statements)

References 46 publications

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“…Although IL-4 is necessary for IgE isotype switching, it is not sufficient. For IgE secretion to occur, a second signal mediated by cell-cell T and B cell interactions via CD40L-CD40 and CD28-CD86 ligand-receptor interactions is needed [115][116][117][118][119][120][121][122][123][124][125][126][127]. IL-4 also induces the lowaffinity IgE receptor CD23 and soluble CD23, which augments B cell IgE synthesis [115,116,[128][129][130][131][132][133].…”

Section: Immunopathogenesis Of Abpa In Cfmentioning

confidence: 99%

Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis—State of the Art: Cystic Fibrosis Foundation Consensus Conference

et al. 2003

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Because of the difficulties of recognizing allergic bronchopulmonary aspergillosis (ABPA) in the context of cystic fibrosis (because of overlapping clinical, radiographic, microbiologic, and immunologic features), advances in our understanding of the pathogenesis of allergic aspergillosis, new possibilities in therapy, and the need for agreed-upon definitions, an international consensus conference was convened. Areas addressed included fungal biology, immunopathogenesis, insights from animal models, diagnostic criteria, epidemiology, the use of new immunologic and genetic techniques in diagnosis, imaging modalities, pharmacology, and treatment approaches. Evidence from the existing literature was graded, and the consensus views were synthesized into this document and recirculated for affirmation. Virulence factors in Aspergillus that could aggravate these diseases, and particularly immunogenetic factors that could predispose persons to ABPA, were identified. New information has come from transgenic animals and recombinant fungal and host molecules. Diagnostic criteria that could provide a framework for monitoring were adopted, and helpful imaging features were identified. New possibilities in therapy produced plans for managing diverse clinical presentations.

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Section: Immunopathogenesis Of Abpa In Cfmentioning

confidence: 99%

Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis—State of the Art: Cystic Fibrosis Foundation Consensus Conference

et al. 2003

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“…It has been found that CsA can also influence functions of other immune cells, including natural killer (NK) cells, macrophages, as well as dendritic cells (Wasowska et al 2001, Sauma et al 2003, Chen et al 2004, Poggi & Zocchi 2005. CsA even modulates the expression of two crucial costimulatory molecules, CD80 and CD86, which are pivotal in the induction of the alloantigen-specific tolerance (Sayegh & Turka 1995, Jirapongsananuruk & Leung 1999, Lee et al 1999. The clinical application of CsA has revolutionized organ transplantation and also improved the therapeutic management of some autoimmune diseases.…”

Section: Introductionmentioning

confidence: 99%

Cyclosporin A improves murine pregnancy outcome in abortion-prone matings: involvement of CD80/86 and CD28/CTLA-4

Zhou¹,

Dong²,

Du³

et al. 2008

Reproduction

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Immune regulation during pregnancy is complex, and thus an optimal therapy for pregnancy complications is always a big challenge to reproductive medicine. Cyclosporin A (CsA), a potent immunosuppressant, prevents rejection of allografts by hosts, but little is known about the modulating effect of CsA on the materno-fetal relationship. Here, pregnant CBA/J females mated with DBA/2 males as an abortion-prone model were administered with CsA on day 4.5 of gestation, and the pregnant CBA/J females mated with BALB/c males were established as successful pregnancy control. It was demonstrated that administration of CsA at the window of implantation significantly up-regulated the expression of CTLA-4, while down-regulating the levels of CD80, CD86, and CD28 at the materno-fetal interface in the CBA/J!DBA/2 abortion-prone matings, and the embryo resorption rate of the abortion-prone matings reduced significantly after CsA treatment, implying that modulation of costimulatory molecule expression by CsA might contribute to preventing the fetus from maternal immune attack. In addition, treatment with CsA induced enhanced growth and reduced cell apoptosis of the murine trophoblast cells. Together, these findings indicate that CsA has a beneficial effect on the materno-fetal interface in abortion-prone matings, leading to a pregnancy outcome improvement, which might provide new therapeutics for spontaneous pregnancy wastage. Reproduction (2008) 135 385-395

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“…The molecular mechanism of the CsA effect was shown to be exhibited by virtue of interfering with the intracellular calcineurin pathway of T cells 9 . On the other hand, a line of evidence has suggested recently that CsA exerts its immunological functions not only on T cells but also on antigen‐presenting cells such as B cells, 10 macrophages 11 and dendritic cells (DCs) 12,13 …”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory effects of cyclosporin A on human peripheral blood dendritic cell subsets

Tajima¹,

Amakawa²,

Ito³

et al. 2003

Immunology

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Summary Cyclosporin A (CsA) is a potent immuno‐suppressant and is approved for the treatment of various disease conditions. The molecular biological mechanism of CsA has been investigated intensively in T cells and has been shown to involve the intracellular calcineurin pathway. Recently, it was reported that CsA has capacities to affect not only T cells but also antigen‐presenting cells such as B cells and dendritic cells (DCs). DCs are a master regulator of immune responses that have an integral capacity to prime naive T cells. In the present study, we investigated the biological effects of CsA on human peripheral blood DC subsets: CD11c+ myeloid and CD11c− lymphoid subsets. CsA inhibited the up‐regulation of co‐stimulatory molecules induced with or without microbial stimuli and CD40L on both CD11c+ and CD11c− subsets. In addition, CsA negatively regulated the endocytic activity of CD11c+ DC during the immature state. CsA inhibited the interleukin‐12 (IL‐12) production, but augmented the IL‐10 production from the LPS‐stimulated CD11c+ subset, whereas CsA reduced the interferon‐α (IFN‐α) production from the CD11c− subset infected with Sendai virus (SV). Both the LPS‐stimulated CD11c+ subset and SV‐infected CD11c− subset preferentially induced the development of IFN‐γ‐producing T helper‐type 1 (Th1) cells. Pretreatment of these DC subsets with CsA inhibited the Th1 skewing. These findings suggested a DC‐mediated mechanism of immunosupression by CsA.

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The modulation of B7.2 and B7.1 on B cells by immunosuppressive agents

Cited by 62 publications

References 46 publications

Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis—State of the Art: Cystic Fibrosis Foundation Consensus Conference

Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis—State of the Art: Cystic Fibrosis Foundation Consensus Conference

Cyclosporin A improves murine pregnancy outcome in abortion-prone matings: involvement of CD80/86 and CD28/CTLA-4

Immunomodulatory effects of cyclosporin A on human peripheral blood dendritic cell subsets

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