The Modulation of Protein Phosphorylation and Receptor Binding in Synaptic Membranes by Changes in Lipid Fluidity: Implications for Ageing

Hershkowitz, Moshe; Heron, David S.; Samuel, David; Shinitzky, Meir

doi:10.1016/s0079-6123(08)63788-7

Cited by 85 publications

(15 citation statements)

References 64 publications

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“…In animals, manipulation of dietary fat can affect neuronal membrane lipid composition and fluidity 43 and possibly also central serotonergic function. 44,45 Statins may affect behavior via their effects on brain cholesterol metabolism [46][47][48][49] and inhibition of coenzyme Q synthesis and protein prenylation.…”

Section: Discussionmentioning

confidence: 99%

Lipid-Lowering Medication Use and Aggression Scores in Women: A Report from the NHLBI-Sponsored WISE Study

Olson

Kelsey

Matthews

et al. 2008

Journal of Women's Health

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Aim-The aim of this study was to examine the association between the use of lipid-lowering medication and aggressive responding, hostility, cynicism, and depression scores in women undergoing coronary angiography.Methods-The cohort included 498 women from the National Heart, Lung and Blood Institute (NHLBI)-sponsored Women's Ischemia Syndrome Evaluation (WISE) study. WISE is a four-center study of women with chest pain who underwent quantitative coronary angiography for suspected myocardial ischemia. The psychosocial indices included the Cook Medley Hostility questionnaire, measuring aggression, hostility, and cynicism, and the Beck Depression Inventory (BDI).Results-Compared to those not on lipid-lowering medication, women receiving lipid-lowering pharmacotherapy were older (62 vs. 55 years, p < 0.001) and had more hypertension, dyslipidemia, diabetes, and coronary artery disease (CAD, defined as ≥50% stenoses in at least one epicardial artery) (all p < 0.003). Women on lipid-lowering medication had higher aggressive responding scores than those not on medication, 3.0 ± 1.8 vs. 2.7 ± 1.7, respectively (age-adjusted p < 0.003). This association persisted after adjustment for coronary risk factors, education, and extent of angiographic disease (CAD) (p < 0.005), and after exclusion of women using psychotropic medications (p < 0.001). Hostility, cynicism, and depression scores did not differ by medication use.Conclusions-In women, lipid-lowering medication may predispose to aggression without affecting hostility or mood, but this hypothesis requires evaluation in placebo-controlled clinical trials.

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Section: Discussionmentioning

confidence: 99%

Lipid-Lowering Medication Use and Aggression Scores in Women: A Report from the NHLBI-Sponsored WISE Study

Olson

Kelsey

Matthews

et al. 2008

Journal of Women's Health

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“…Therefore, neuronal gangliosides were investigated since these synaptically en riched glycolipids are assumed to play an im portant role in the process of neuronal trans mission [29] and by this might be responsible for age-dependent changes in several neuro nal functions [16,28]. The data presented in this study clearly demonstrate that the con centration especially of ganglioside-bound neuraminic acid alters considerably in the rat brain during the life span.…”

Section: Discussionmentioning

confidence: 78%

Brain Gangliosides during the Life Span (Embryogenesis to Senescence) of the Rat

Hilbig¹,

Lauke²,

Rahmann³

1983

Dev Neurosci

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The concentration of gangliosides, sialoglycoproteins and proteins was studied in the whole brains and single brain structures (cortex, olfactory bulb, corpora quadrigemina region ≙ midbrain, cerebellum, thalamic region and oblongated medulla) of female rats from 14 developmental stages ranging from day 8 of gestation to more than 3 years of age. The content of protein- and ganglioside-bound neuraminic acid showed a peak at 3 weeks of age and then decreased with aging, whereas that of proteins increased until senescence. All over the life span the developmental profiles of 12 individual gangliosides in the different brain structures (cortex, corpora quadrigemina region ≙ midbrain, cerebellum, thalamic region, medulla) and in whole brain samples were followed. There are distinct differences between the brain structures. Additionally each brain region is characterized by specific developmental ganglioside profiles. However, some ganglioside changes are common to all regions: G_D3 in general is a marker for cell division and migration, whereas the polar ganglioside fractions G_Q1b and G_P1 are characteristic for nerve cell sprouting and arborization. Especially in the cortex G_D1a seems to be the marker for synaptogenesis and G_M1 and G_M4 for myelination. The results were discussed in view of the main morphological patterns of differentiation.

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“…4). We postulated that the PUFA effect demonstrated here could only partially be associated with membrane fluidity10 because the relationship between ligand binding and membrane viscosity was reported to vary for different receptors 17. Rather, the role of other cellular regulatory mechanisms, such as the adjustment of receptor sensitivity by phosphorylation, may offer an explanation 18,19…”

Section: Summary Of the Datamentioning

confidence: 85%

Systemic Effects of Dietary n‐3 PUFA Supplementation Accompany Changes of CNS Parameters in Cerebral Hypoperfusion

Farkas

Wilde

Kiliaan³

et al. 2002

Annals of the New York Academy of Sciences

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Dietary supplementation with long-chain polyunsaturated fatty acids (PUFAs) has become an attractive possibility to alleviate or prevent cerebrovascular pathophysiology. To characterize the potentially beneficial cerebrovascular action of n-3 PUFAs that predominantly occur in fish oil, we set up an experimental paradigm where rats with chronic cerebral hypoperfusion were supplied with n-3 PUFA-enriched diets. Cerebral hypoperfusion was created by a permanent, bilateral occlusion of the common carotid arteries (2VO) of rats at the age of 4 months, with a survival of 3 months. Simultaneously, the rats were provided with experimental diets from the time of weaning until the termination of the experiments. The control diet was comparable to standard rat chow, while diet 1 contained additional n-3 PUFAs and diet 2 was further enriched with structural phospholipids and neurotransmitter precursors. In summary, the data show that diet 2 improved spatial learning of 2VO rats in the Morris water maze. Both diet 1 and diet 2 augmented blood-brain barrier parameters and increased the density of the M1-type muscarinic cholinergic receptors in the hippocampus independent of the rate of cerebral perfusion. In addition to an overview of these results, changes that were supportive or accompanying those described in the CNS are also presented. Briefly, plasma corticosterone concentration was elevated most explicitly by 2VO, while the relative weight of the liver and spleen increased due to the diets. The data draw attention to changes not only in the CNS, but also in the periphery as a consequence of chronic supplementation with n-3 PUFA-enriched diets.

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The Modulation of Protein Phosphorylation and Receptor Binding in Synaptic Membranes by Changes in Lipid Fluidity: Implications for Ageing

Cited by 85 publications

References 64 publications

Lipid-Lowering Medication Use and Aggression Scores in Women: A Report from the NHLBI-Sponsored WISE Study

Lipid-Lowering Medication Use and Aggression Scores in Women: A Report from the NHLBI-Sponsored WISE Study

Brain Gangliosides during the Life Span (Embryogenesis to Senescence) of the Rat

Systemic Effects of Dietary n‐3 PUFA Supplementation Accompany Changes of CNS Parameters in Cerebral Hypoperfusion

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