The Modulatory Activity of <i>Justicia carnea</i> in Plasmodium Infected Mice

Abstract

The study investigated the antiplasmodial potency of Justicia carnea in plasmodium infected mice. The aqueous leaf extract of Justicia carnea was subjected to phytochemical screening using GC-FID. The suppressive, prophylactic and curative activity of the studied plant was accessed after oral administration of standard drugs (5mgkg-1 choroquine and 4mgkg-1 artesunate) and 400-800mgkg-1 of the extract. The effect of the aqueous leaf extract of the studied plant was also explored in the activities of liver enzymes, oxidative stress markers and hematological indices of plasmodium infected mice using spectrophotomertic methods and a hematology auto analyzer (BC 5300 Mindray England) respectively. The aqueous leaf extract of Justicia carnea showed considerable dose dependent antiplasmodial activity in the suppressive, prophylactic and curative test conducted. The suppressive activity of (92%) of the aqueous leaf extract of the studied plant at 800mgkg-1 was comparable to the standard drugs used while the mean survival time of plasmodium infected mice at 800mgkg-1 was beyond the mean survival time of the infected untreated group. The aqueous leaf extract of the studied plant also exhibited significant improvements in the activities of liver enzymes, oxidative stress markers and some hematological parameters at 800mgkg-1 of the extract when compared with the infected and untreated group. The results of the study exhibited the antiplasmodial activity of the studied plant, nonetheless, the crude extracts of the studied plant can be further purified for synergistic use with other potent antimalarial drugs to combat and achieve total clearance of plasmodium resistant infections.

Pharmacological Efficacy of Ethanol Leaf Extract of Justicia secunda in Swiss Albino Mice Experimentally Infected with Plasmodium berghei

“…One of the major foci of this study is to include Justicia secunda in the record of antimalarial study, and the crude extract has a percentage chemosuppression of 71.21% (1,500 mg/kg) and 75.18% (1,500 mg/kg) in the suppressive and curative tests, respectively. The result is less than the antimalarial activity of the ethanol leaf extract of Justicia carnea (800 mg/kg dose) with a percentage chemosuppression of 82% [42]. The e cacy of plant extracts in treating malaria disease depends on several factors, such as the Plasmodium species, the dosage, the duration of treatment, and the host immune response [43].…”

Green Synthesis, Characterization and In-vitro Antioxidant Property of Silver Nanoparticles Using the Aqueous Leaf Extract of Justicia carnea

“…Justicia carnea belongs to the Acanthaceae family, it is an ornamental plant with about 250 genera and 2500 species [17]. Its common names include Brazilian plume flower, flamingo flower and Jacobinia [18,19].…”

“…It is a medicinal plant used widely in Nigeria reported to have diverse functions, including blood-boosting potential [21]. J. carnea has been reported to exhibit therapeutic properties such as hypoglycemic [21], antidiabetic [22], antioxidant [20,23], antiplasmodial [17], and anti-anemic and alleviation of lipid profile [24,25]. There is no documented scientific and experimental evidence on the use of Justicea carnea leaves in the synthesis of silver nanoparticles.…”