The Modulatory Effect of Anthocyanins from Purple Sweet Potato on Human Intestinal Microbiota in Vitro

Zhang, Xin; Yang, Yang; Wu, Zufang; Weng, Peifang

doi:10.1021/acs.jafc.6b00586

Cited by 110 publications

(82 citation statements)

References 38 publications

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“…and Lactobacillus spp.) . In this study, we hypothesized that continuous polyphenol intake would increase systemic exposure to gallotannin metabolites due to changes in gut microbial composition.…”

Section: Discussionmentioning

confidence: 99%

Body Mass Index as a Determinant of Systemic Exposure to Gallotannin Metabolites during 6‐Week Consumption of Mango (Mangifera indica L.) and Modulation of Intestinal Microbiota in Lean and Obese Individuals

Barnes

Kim

Fang

et al. 2018

Molecular Nutrition Food Res

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Scope This human clinical pilot trial investigated pharmacokinetics of gallotannin‐metabolites and modulation of intestinal microbiota in healthy lean and obese individuals after 6 weeks of daily mango consumption. Methods and results Participants are divided into three groups: Lean Mango (LM: n = 12; BMI = 22.9 kg m−2), Obese Mango (OM: n = 9; BMI = 34.6 kg m−2), and Lean Control (LC: n = 11; BMI = 22.1 kg m−2). LM and OM consumed 400 g of mango per day for 6 weeks. LC consumed mango only on Days 0 and 42. After 6 weeks, LM experienced increased systemic exposure (AUC0–8h) to gallotannin‐metabolites, 1.4‐fold (p = 0.043). The greatest increase is 4‐O‐methyl‐gallic acid, 3.3‐fold (p = 0.0026). Cumulative urinary excretion of gallotannin‐metabolites significantly increased in LM and OM, but not LC. For OM, qPCR data show increased levels of tannase‐producing Lactococcus lactis and decreased levels of Clostridium leptum and Bacteroides thetaiotaomicron, bacteria associated with obesity. LM experienced an increased trend of fecal levels of butyric (1.3‐fold; p = 0.09) and valeric acids (1.5‐fold; p = 0.056). Plasma endotoxins showed a decreased trend in LM and OM. Conclusion Continuous mango intake significantly increased systemic exposure to gallotannin‐ metabolites and induced an increased trend for fecal short‐chain fatty acids in lean but not obese individuals. This pharmacokinetic discrepancy may result in BMI‐associated reduced gallotannin‐derived health benefits.

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Section: Discussionmentioning

confidence: 99%

Body Mass Index as a Determinant of Systemic Exposure to Gallotannin Metabolites during 6‐Week Consumption of Mango (Mangifera indica L.) and Modulation of Intestinal Microbiota in Lean and Obese Individuals

Barnes

Kim

Fang

et al. 2018

Molecular Nutrition Food Res

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“…The production of SCFA is a consequence of the metabolism of intestinal microbiota, and its ratio and concentration are influenced by intestinal microbiota and diet dramatically (Zhang et al, 2016). With elevated faecal SCFA concentrations, SCFA-producing bacteria may promote the energy intake from fibres, and prevent the hosts from inflammation, opportunistic pathogens and colonic diseases (Filippoa et al, 2010).…”

Section: Interestingly Certain Bacterial Communities Such Asmentioning

confidence: 99%

Green tea polyphenols reduce obesity in high‐fat diet‐induced mice by modulating intestinal microbiota composition

Guo

Cheng

Zhang

et al. 2017

Int J of Food Sci Tech

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Summary In this study, the modulatory effect of green tea polyphenols (GTP) on human intestinal microbiota was investigated. Firstly, germ‐free mice were inoculated with faecal suspension derived from healthy volunteers to obtain human flora‐associated (HFA) mice model. When the high‐fat diet‐induced obese mice model was successfully established, they were randomly divided into high‐fat diet group (HFD) and high‐fat diet group with GTP (HFD‐GTP), and the shifts in relative abundance of the dominant taxa at the phylum, family and genus levels were studied by high‐throughput sequencing. The diversity of the total bacterial community reached the maximum after GTP treatment for 3 weeks, and then decreased when the mice were fed without GTP. Despite interindividual variation, the relative abundance of Bacteroidetes increased from 0.56 ± 0.06 (1st week) to 0.60 ± 0.05 (3th week), while Firmicutes decreased from 0.42 ± 0.06 to 0.37 ± 0.02. Interestingly, certain bacterial communities such as Bacteroidetes and Proteobacteria still increased and Firmicutes showed a decreasing trend when the mice were fed without GTP (4th week). The results showed that GTP benefits the stability of certain gut microbiota, especially in an environment‐triggered microbial imbalance; therefore, it may have prebiotic‐like activity contributing to the prevention of obesity.

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“…was increased and the growth of less beneficial Bacteroides, Prevotella , and C. histolyticum was inhibited. Moreover, concentration of SCFA and lactic acid in the PSPA cultures were also high . In another study, 5 mL of tart cherry treatment for 48 h in vitro using conditions which mimicked gastric, intestine, and colon environments (15 mL) increased Bacteroides and Bifidobacterium which could be associated with increased chlorogenic acid in tart cherry juice concentrate.…”

Section: Impact Of Gut Microbiota On Obesity and Inflammationmentioning

confidence: 94%

“…Moreover, Lactobacillus spp . may also be involved in modulating permeability of intestine, inflammation, adiposity, and body weight, weight, and also the bacteria's abundance can be increased by anthocyanin supplement …”

Section: Impact Of Gut Microbiota On Obesity and Inflammationmentioning

confidence: 99%

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Protective Effects of Anthocyanins in Obesity‐Associated Inflammation and Changes in Gut Microbiome

Jayarathne

Stull

Park

et al. 2019

Molecular Nutrition Food Res

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Obesity is a complex disease and a major public health epidemic. Chronic, low‐grade inflammation is a common underlying feature of obesity and associated metabolic diseases; adipose tissue is a major contributor to this systemic inflammation. Evidence shows that obesity‐associated inflammation may originate from gut dysfunction, including changes in intestinal bacteria or microbiome profiles. Increasingly, food and plant bioactive compounds with antioxidant and anti‐inflammatory properties are proposed to ameliorate obesity‐associated inflammation. Among these, the health‐promoting effects of anthocyanin‐rich foods are of interest here. Specifically, this review summarizes the reported benefits of anthocyanins in obesity‐associated inflammation and underlying molecular mechanisms, including the role of gut microbiome and cell signaling pathways regulated by anthocyanins both in vivo and in vitro.

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The Modulatory Effect of Anthocyanins from Purple Sweet Potato on Human Intestinal Microbiota in Vitro

Cited by 110 publications

References 38 publications

Body Mass Index as a Determinant of Systemic Exposure to Gallotannin Metabolites during 6‐Week Consumption of Mango (Mangifera indica L.) and Modulation of Intestinal Microbiota in Lean and Obese Individuals

Body Mass Index as a Determinant of Systemic Exposure to Gallotannin Metabolites during 6‐Week Consumption of Mango (Mangifera indica L.) and Modulation of Intestinal Microbiota in Lean and Obese Individuals

Green tea polyphenols reduce obesity in high‐fat diet‐induced mice by modulating intestinal microbiota composition

Protective Effects of Anthocyanins in Obesity‐Associated Inflammation and Changes in Gut Microbiome

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