The modulatory effects of MU and Kappa opioid agonists on 5-HT release from hippocampal and hypothalamic slices of euthermic and hibernating ground squirrels

Cui, Yan; Lee, T. F.; Крамарова, Л. И.; Wang, L. C.H.

doi:10.1016/0024-3205(93)90017-w

Cited by 19 publications

(3 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As it has been shown previously that the concentration of TTX used (1 µM) was able to prevent any indirect effect via intermediate neuronal pathways (Cui et al, 1993), the failure of TTX to modify the effects of GKB cannot be due to an insufficient concentration. On the other hand, the insensitivity of GKB's effect to TTX indicates that GKB interacts with β-amyloid peptides directly, rather than indirectly through serotonergic or other systems, on the cholinergic terminals.…”

Section: Discussionmentioning

confidence: 78%

Effect of ginkgolides on β‐amyloid‐suppressed acetylocholine release from rat hippocampal slices

Lee

Chen²,

Wang

2004

Phytotherapy Research

View full text Add to dashboard Cite

As Ginkgo has been shown to improve age-related memory de fi cits and beta-amyloid-related peptides have been suggested to play a signi fi cant role in memory degeneration in Alzheimer's disease, the present study was carried out to examine the effect of two major ginkgolides, A and B, on beta-amyloid peptide-modulated acetylcholine (ACh) release from hippocampal brain slices. Addition of beta-amyloid fragment(25-35) (0.01-1 micro M) in the superfusion medium suppressed the K(+)-evoked [(3)H]-ACh release from the rat hippocampal slices in a concentration-related manner; a 40% reduction in ACh out fl ow was observed with the highest amyloid concentration used (1 micro M). Inclusion of ginkgolide B (GKB, 0.01-10 micro M) caused a concentration-related reversion of the inhibitory effect elicited by the effective concentration of beta-amyloid (1 micro M). The reversal of the beta-amyloid-inhibited ACh release by GKB (1 micro M) was not blocked by tetrodotoxin (1 micro M) indicating a direct interaction of GKB on the cholinergic nerve terminals. In contrast, addition of the same concentration range of ginkgolide A (GKA, 0.01-10 micro M) had no effect on beta-amyloid-inhibited ACh release. These results suggest that GKB may elicit its anti-amnesic effect by minimizing the inhibitory effect of beta-amyloid peptides on cholinergic transmission.

show abstract

Section: Discussionmentioning

confidence: 78%

Effect of ginkgolides on β‐amyloid‐suppressed acetylocholine release from rat hippocampal slices

Lee

Chen²,

Wang

2004

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…Support for this idea came from the finding that DADLE inhibited serotonin normally, but not in hibernation (282). Similarly, U50,488 enhanced release of serotonin from slices of hippocampus during nonhibernation but not during hibernation, and the potentiation was inhibited by norbinaltorphimine, implicating the ~ receptors (102). DAMGO inhibited serotonin release from hippocampus slices, in a naloxone-reversible way, in both hibernating and nonhibernating ground squirrels, and in the hypotfialamus, DAMGO and U50,488 produced release of serotonin in both states, indicating a complex nature of the roles of different opiates in regular hibernation (102).…”

Section: Other Behaviorsmentioning

confidence: 99%

Endogenous opiates: 1993

Olson

Kastin

1994

Peptides

View full text Add to dashboard Cite

This paper is the sixteenth installment of our annual review of research concerning the opiate system. It is restricted to papers published during 1993 that concern the behavioral effects of the endogenous opiate peptides, and does not include papers dealing only with their analgesic properties. The specific topics this year include stress; tolerance and dependence; eating; drinking; gastrointestinal, renal, and hepatic function; mental illness and mood; learning, memory, and reward; cardiovascular responses; respiration and thermoregulation; seizures and other neurological disorders; electrical-related activity; general activity and locomotion; development; immunological responses; and other behaviors.

show abstract

“…Hibernating mammals have been investigated in attempts to identify and isolate factors responsible for regulating this tolerance. This research has identified a variety of factors including hormones (7,21) and opioids (10,23,45,47) with a demonstrated capacity to regulate hibernation.…”

mentioning

confidence: 99%

Effects of plasma from hibernating ground squirrels on monocyte-endothelial cell adhesive interactions

Yasuma

McCarron

Spatz

et al. 1997

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

Adhesion and subsequent penetration of leukocytes into central nervous system ischemic tissue proceeds via a coordinated inflammatory mechanism involving adhesion molecules at the blood-endothelium interface. Mammalian hibernation is a state of natural tolerance to severely reduced blood flow-oxygen delivery (i.e., ischemia). Hibernating thirteen-lined ground squirrels were investigated in an attempt to identify factors responsible for regulating this tolerance. Since leukocytopenia is closely associated with entrance into hibernation, the role of leukocyte adhesion to endothelium in this phenomenon was examined. Intercellular adhesion molecule-1 (ICAM-1) is expressed by endothelium and regulates interactions with circulating leukocytes that may result in margination or extravasation. ICAM-1 expression by rat cerebral microvascular endothelial cells (EC) cultured with plasma from hibernating (HP) or nonhibernating (NHP) thirteen-lined ground squirrels was dose dependently increased by HP and, to a lesser extent, by NHP. Treatment of EC with HP coincidentally induced significantly greater increases in monocyte adhesion to EC (37.2%) than were observed with NHP (23.9%). Study of the effects of HP and NHP on monocyte adhesion to EC may identify mechanisms responsible for ischemic tolerance in hibernators and could lead to the development of novel therapeutic approaches to the treatment of stroke.

show abstract

The modulatory effects of MU and Kappa opioid agonists on 5-HT release from hippocampal and hypothalamic slices of euthermic and hibernating ground squirrels

Cited by 19 publications

References 20 publications

Effect of ginkgolides on β‐amyloid‐suppressed acetylocholine release from rat hippocampal slices

Effect of ginkgolides on β‐amyloid‐suppressed acetylocholine release from rat hippocampal slices

Endogenous opiates: 1993

Effects of plasma from hibernating ground squirrels on monocyte-endothelial cell adhesive interactions

Contact Info

Product

Resources

About