The modulatory effects of nicotine on parietal cortex activity in a cued target detection task depend on cue reliability

Gießing, Carsten; Thiel, Christiane M.; Rösler, Frank; Fink, Gereon R.

doi:10.1016/j.neuroscience.2005.10.005

Cited by 95 publications

(75 citation statements)

References 54 publications

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“…Interestingly, while reducing neural activity in invalid trials in the 90% cue validity condition, nicotine increased activity in invalid trials in the 60% cue validity condition in parietal brain areas (superior parietal cortex/IPS, angular gyrus). These results might seem inconsistent with the findings of Giessing et al (2006) showing reduced activity in areas adjacent to the intraparietal sulcus in invalid trials in the context of 64% cue validity. One possible reason for these discrepancies could be the use of two different cues in the present study.…”

Section: Neural Datacontrasting

confidence: 95%

“…One possible reason for these discrepancies could be the use of two different cues in the present study. Whereas the study by Giessing et al (2006) employed one cue type only (ie, cue validity was manipulated across different experimental blocks), the task in this study required a matching of cue identity (green, blue) and cue validity (90, 60%). This could have emphasized the differences between the two experimental conditions, thereby possibly promoting the observed dissociation in the neuromodulatory effects of nicotine in the two cue validity conditions.…”

Section: Neural Datamentioning

confidence: 99%

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Behavioral and Neural Effects of Nicotine on Visuospatial Attentional Reorienting in Non-Smoking Subjects

Vossel

Thiel

Fink

2007

Neuropsychopharmacol

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The cholinergic neurotransmitter system has been proposed to be involved in the processing of probabilistic top-down information provided by endogenous cues in location-cueing paradigms. It has been shown that the behavioral and neural effects of a nicotinic cholinergic stimulation resemble the effects obtained by manipulating the validity of the spatial cues: enhancing cortical nicotine levels and decreasing cue validity both reduce the reaction time difference between invalidly and validly cued targets (ie, the 'validity effect') as well as neural activity related to attentional reorienting in parietal brain regions. In the present study, we investigated whether the behavioral and neural effects of nicotine in location-cueing paradigms are dependent upon different a priori cue validities. Twenty-four subjects were investigated in a double-blind placebo-controlled between-subject design with functional magnetic resonance imaging. Nicotine was administered to non-smoking volunteers via polacrilex gums (Nicorette s , 2 mg) before performing a location-cueing paradigm with valid and invalid cues in the context of 90 and 60% cue validity in the MR scanner. Nicotine significantly reduced the validity effect in the 90% but not in the 60% cue validity condition. Fronto-parietal and cingulate regions showed stronger nicotinic reductions of reorientingrelated neural activity in the high than in the low cue validity condition. Our data reveal an interaction effect between the pharmacological and cognitive modulation of attentional reorienting, which is evident at both a behavioral as well as the neuronal level.

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Section: Neural Datacontrasting

confidence: 95%

Section: Neural Datamentioning

confidence: 99%

Behavioral and Neural Effects of Nicotine on Visuospatial Attentional Reorienting in Non-Smoking Subjects

Vossel

Thiel

Fink

2007

Neuropsychopharmacol

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“…Because this task combines diverse cognitive components, no link between more specialized neuroanatomy and specific attentional functions could be established. Later studies identified nicotine-induced activity decreases in intraparietal sulcus that accompanied effects on attentional reorienting (Thiel et al, 2005;Giessing et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Nicotine Enhances Visuospatial Attention by Deactivating Areas of the Resting Brain Default Network

Hahn¹,

Ross²,

Yang³

et al. 2007

J. Neurosci.

187

165

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Nicotine-induced attentional enhancement is of potential therapeutic value. To investigate the precise attentional function(s) affected and their neuronal mechanisms, the current functional magnetic resonance imaging (fMRI) study used an attention task in which subjects responded to stimuli of high (INT high ) or low intensity presented randomly in one of four peripheral locations. Central cues of varying precision predicted the target location. In some trials, the cue was not followed by a target, allowing separate analysis of blood oxygenation level-dependent (BOLD) responses to cue. Minimally deprived smokers underwent fast event-related fMRI twice: once with a nicotine patch (21 mg) and once with a placebo patch. Matched nonsmokers were scanned twice without a patch. Behaviorally, nicotine reduced omission errors and reaction time (RT) of valid and invalid cue trials and intra-individual variability of RT and did so preferentially in trials with INT high . The BOLD signal related to cue-only trials, regardless of cue precision, demonstrated nicotine-induced deactivation in anterior and posterior cingulate, angular gyrus, middle frontal gyrus, and cuneus. These regions overlapped with the so-called "default network," which activates during rest and deactivates with attention-demanding activities. Partial correlations controlling for nicotine plasma levels indicated associations of deactivation by nicotine in posterior cingulate and angular gyrus with performance improvements under INT high . Performance and regional activity in the absence of nicotine never differed between smokers and nonsmokers, ruling out a simple reversal of a deprivation-induced state. These findings suggest that nicotine improved attentional performance by downregulating resting brain function in response to task-related cues. Together with the selectivity of effects for INT high , this suggests a nicotine-induced potentiation of the alerting properties of external stimuli.

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“…However, despite this converging evidence of nicotine effects on enhancing neural processing efficiency (Ettinger et al, 2009;Giessing et al, 2006;Thiel et al, 2005;Wylie et al, 2012), it is important to note that other studies have shown nicotine-induced increase of BOLD response in other brain areas combined with improved performance on relatively more demanding tasks (Kumari et al, 2003). Thus, there is likely not a single or consistent neural signature of nicotine;…”

Section: Accepted M Manuscriptmentioning

confidence: 98%

“…For example, reduced cue-related BOLD response in parietal cortex following nicotine administration has been observed in selective attention paradigms (Giessing et al, 2006;Thiel et al, 2005). Connectivity analysis with resting-state fMRI has revealed more efficient information transfer with a single dose of nicotine (Wylie et al, 2012).…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

Neural effects of methylphenidate and nicotine during smooth pursuit eye movements

et al. 2016

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Citation for published version (APA):Kasparbauer, A-M., Meyhöfer, I., Steffens, M., Weber, B., Aydin, M., Kumari, V., ... Ettinger, U. (2016). Neural effects of methylphenidate and nicotine during smooth pursuit eye movements. NeuroImage. DOI: 10.1016DOI: 10. /j.neuroimage.2016 Citing this paper Please note that where the full-text provided on King's Research Portal is the Author Accepted Manuscript or Post-Print version this may differ from the final Published version. If citing, it is advised that you check and use the publisher's definitive version for pagination, volume/issue, and date of publication details. And where the final published version is provided on the Research Portal, if citing you are again advised to check the publisher's website for any subsequent corrections. General rightsCopyright and moral rights for the publications made accessible in the Research Portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognize and abide by the legal requirements associated with these rights.•Users may download and print one copy of any publication from the Research Portal for the purpose of private study or research.•You may not further distribute the material or use it for any profit-making activity or commercial gain •You may freely distribute the URL identifying the publication in the Research Portal Take down policy If you believe that this document breaches copyright please contact librarypure@kcl.ac.uk providing details, and we will remove access to the work immediately and investigate your claim. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT AbstractIntroduction: Nicotine and methylphenidate are putative cognitive enhancers in healthy and patient populations. Although they stimulate different neurotransmitter systems, they have been shown to enhance performance on overlapping measures of attention. So far, there has been no direct comparison of the effects of these two stimulants on behavioural performance or brain function in healthy humans. Here, we directly compare the two compounds using a wellestablished oculomotor biomarker in order to explore common and distinct behavioural and neural effects. Methods: Eighty-two healthy male non-smokers performed a smooth pursuit eye movement task while lying in an fMRI scanner. In a between-subjects, double-blind design, subjects either received placebo (placebo patch and capsule), nicotine (7mg nicotine patch and placebo capsule), or methylphenidate (placebo patch and 40mg methylphenidate capsule).Results: There wer...

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The modulatory effects of nicotine on parietal cortex activity in a cued target detection task depend on cue reliability

Cited by 95 publications

References 54 publications

Behavioral and Neural Effects of Nicotine on Visuospatial Attentional Reorienting in Non-Smoking Subjects

Behavioral and Neural Effects of Nicotine on Visuospatial Attentional Reorienting in Non-Smoking Subjects

Nicotine Enhances Visuospatial Attention by Deactivating Areas of the Resting Brain Default Network

Neural effects of methylphenidate and nicotine during smooth pursuit eye movements

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