The modulatory effects of the volatile oil of ginger on the cellular immune response in vitro and in vivo in mice

Zhou, Hantao; Deng, Yifeng; Xie, Qiang-min

doi:10.1016/j.jep.2005.10.022

Cited by 88 publications

(55 citation statements)

References 15 publications

(17 reference statements)

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“…The anti-inflammatory properties of ginger are mediated by inhibiting the production of nitric oxide, inflammatory cytokines and arachidonic acid [20]. It also modulates the lymphocytes function, so it might exert beneficial effects in a number of clinical conditions such as chronic inflammation and autoimmune diseases [21].…”

Section: Introductionmentioning

confidence: 99%

The Effect of N. Acetylcysteine and Ginger on Acetic Acid Induced Colitis in Adult Male Albino Rat: Histological, Immunohistochemical and Morphometric Study

El-Galil¹,

ElGhamrawy²

2015

J Cytol Histol

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Section: Introductionmentioning

confidence: 99%

The Effect of N. Acetylcysteine and Ginger on Acetic Acid Induced Colitis in Adult Male Albino Rat: Histological, Immunohistochemical and Morphometric Study

El-Galil¹,

ElGhamrawy²

2015

J Cytol Histol

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“…The volatile oil of Zingiber officinale with zingiberene, ar-curcumene, β-bisabolene and α-sesquiphellandrene as the major components, has shown to be effective in decreasing severity and extent of inflammation in a rat model of colitis (Rashidian et al, 2014). In another study, evaluating the volatile oil of ginger (with zingiberene as the dominant composition) in vitro and in vivo has suggested the impact of the oil in cell-mediated immune response and nonspecific proliferation of T-cell which might play a role in inflammatory conditions (Zhou et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Volatile Constituents of Ginger Oil Prepared According to Iranian Traditional Medicine and Conventional Method: A Comparative Study

Shirooye¹,

Mokaberinejad²,

Ara³

et al. 2016

Afr J Tradit Complement Altern Med

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Background: Herbal medicines formulated as oils were believed to possess more powerful effects than their original plants in Iranian Traditional Medicine (ITM). One of the popular oils suggested for treatment of various indications was ginger oil. In the present study, to suggest a more convenient method of oil preparation (compared to the traditional method), ginger oil has been prepared according to both the traditional and conventional maceration methods and the volatile oil constituents have been compared. Material and Methods: Ginger oil was obtained in sesame oil according to both the traditional way and the conventional (maceration) methods. The volatile oil of dried ginger and both oils were obtained by hydro-distillation and analyzed by gas chromatography/mass spectroscopy. Results: Fifty five, fifty nine and fifty one components consisting 94 %, 94 % and 98 % of the total compounds were identified in the volatile oil of ginger, traditional and conventional oils, respectively. Conclusion:The most dominant compounds of the traditional and conventional oils were almost similar; however they were different from ginger essential oil which has also been to possess limited amounts of anti-inflammatory components. It was concluded that ginger oil could be prepared through maceration method and used for indications mentioned in ITM.

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“…O óleo volátil do gengibre inibe a secreção de IL-1 em macrófagos induzidos por LPS in vitro (ZHOU, DENG, XIE, 2006). Assim como o componente 6-gingerol diminui a secreção de IL-1, IL-12 e TNF-α (TRIPATHI et al, 2007).…”

Section: Efeito Antagônico Do Gengibre Sobre O Lpsunclassified

“…Assim como o componente 6-gingerol diminui a secreção de IL-1, IL-12 e TNF-α (TRIPATHI et al, 2007). O extrato de gengibre inibe a produção de IL-2 (WILASRUSMEE et al, 2002), e isso pode ter ocorrido devido a diminuição de IL-1 (ZHOU, DENG, XIE 2006 A ciclooxigenase 2 (COX-2), é uma enzima, normalmente induzível, que participa da via do ácido araquidônico produzindo mediadores da inflamação como a prostaglandina E2 (PGE2) (ROBBINS & COTRAN, 2010). Ha et al (2012) verificaram que o 6-shogaol inibiu a produção de PGE2 e citocinas pró inflamatórias como a IL-1β e o TNF-α, através da regulação negativa de COX-2, da subfamília de proteínas ativadas por mitógeno p38 (p38 MAPK) e do fator de transcrição NF-KB.…”

Section: Efeito Antagônico Do Gengibre Sobre O Lpsunclassified

Efeito anti-inflamatório do gengibre e possível via de sinalização

Vieira

Tomiotto

Melo

et al. 2014

Semin. Cienc. Biol. Saude

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O gengibre (Zingiber officinale Roscoe) vem sendo utilizado tanto na medicina natural tradicional quanto contemporânea, sendo descritos mais de 115 componentes do gengibre fresco e seco. Dentre esses componentes, os compostos fenólicos, gingerol e o shoagol, têm sido amplamente estudados apresentando diferentes propriedades destas moléculas como efeito antipirético, analgésico, inibidor da angiogênese, atividades imunomoduladoras, entre outras. Esta revisão tem como objetivo apresentar os componentes do gengibre assim como o seu efeito antagônico sobre o lipopolissacarídeo (LPS), propriedade anti-inflamatória e possível via de sinalização envolvida. O efeito do gengibre sobre o LPS consiste na inibição da produção de Interleucina 12 (IL -12), resultando em menor ativação de macrófagos induzidos pelo LPS; diminuição na expressão de moléculas co-estimulatórias e expressão de MHC classe II e diminuição de Interleucina 2 (IL-2), suprimindo a ativação e proliferação de células T CD4+. A propriedade anti-inflamatória do composto está relacionada com a capacidade de modular o linfócito T, de forma a inibir a eosinofilia, reduzir a quantidade de mastócitos, inibir a liberação de IL-4 e reduzir a resposta Th2. Além disso, pode ocorrer inibição da translocação da subunidade p65 para o núcleo e inibição da fosforilação do complexo IkB-α, culminando com a diminuição dos níveis de COX-2. Através deste estudo, podemos concluir que componentes do gengibre podem atuar antagonicamente sobre o efeito de ativação do LPS em macrófagos, conduzindo um efeito imunomodulador e anti-inflamatório, no qual a possível via de sinalização afetada seja do NFkB com envolvimento das MAPquinases. Palavras-Chave: Zingiber officinale Roscoe. Gingerol. Shogaol. Inflamação AbstractGinger (Zingiber officinale Roscoe) has been used in both traditional and contemporary natural medicine, with over 115 described components of fresh and dried ginger. Among these components, the phenolic compounds: gingerol and shoagol have been broadly studied and these molecules have different properties, such as antipyretic, analgesic, angiogenesis inhibitor, immunomodulatory activities, among others. This review aims to present the components of ginger as well as its antagonistic effect on LPS, anti -inflammatory property and possible signaling pathway involved. The effect of ginger on lipopolysaccharide (LPS) consists in inhibiting the production of interleukin 12 (IL-12), resulting in reduced activation of macrophages induced by LPS; decreased expression of co-stimulatory molecules and MHC class II expression and reduced IL-2, impairing the activation and proliferation of CD4 + T cells. The anti-inflammatory property of the compound is associated with the ability to modulate T lymphocyte, in order to inhibit eosinophilia, reducing the amount of mast cells and inhibit the release

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The modulatory effects of the volatile oil of ginger on the cellular immune response in vitro and in vivo in mice

Cited by 88 publications

References 15 publications

The Effect of N. Acetylcysteine and Ginger on Acetic Acid Induced Colitis in Adult Male Albino Rat: Histological, Immunohistochemical and Morphometric Study

The Effect of N. Acetylcysteine and Ginger on Acetic Acid Induced Colitis in Adult Male Albino Rat: Histological, Immunohistochemical and Morphometric Study

Volatile Constituents of Ginger Oil Prepared According to Iranian Traditional Medicine and Conventional Method: A Comparative Study

Efeito anti-inflamatório do gengibre e possível via de sinalização

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