The Modulatory Influence of Plant-Derived Compounds on Human Keratinocyte Function

Abstract

The plant kingdom is a rich source of secondary metabolites with numerous properties, including the potential to modify keratinocyte biology. Keratinocytes are important epithelial cells that play a protective role against various chemical, physical and biological stimuli, and participate in reactive oxygen scavenging and inflammation and wound healing processes. The epidermal cell response may be modulated by phytochemicals via changes in signal transduction pathways. Plant extracts and single secondary compounds can possess a high antioxidant capacity and may suppress reactive oxygen species release, inhibit pro-apoptotic proteins and apoptosis and activate antioxidant enzymes in keratinocytes. Moreover, selected plant extracts and single compounds also exhibit anti-inflammatory properties and exposure may result in limited production of adhesion molecules, pro-inflammatory cytokines and chemokines in keratinocytes. In addition, plant extracts and single compounds may promote keratinocyte motility and proliferation via the regulation of growth factor production and enhance wound healing. While such plant compounds may modulate keratinocyte functions, further in vitro and in vivo studies are needed on their mechanisms of action, and more specific toxicity and clinical studies are needed to ensure their effectiveness and safety for use on human skin.

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“…In Keratinocyte and macrophage cells viability 27 study, Keratinocyte and macrophage cells are treated with different concentrations of aqueous extract, 70% ethanolic extract and also compounds (i-iv) that are Iriflophenone 3,5-C-β-D diglucoside (i) Iriflophenone 3-C-β-D glucoside (ii), mangiferin (iii), genkwanin 5-o-β-primevoside (iv) respectively. After the cells were treated with those extracts for 24 h, the number of surviving cells was determined using MTT assay.…”

Plants as Modulators of Melanogenesis: Role of Extracts, Pure Compounds and Patented Compositions in Therapy of Pigmentation Disorders

“…Annual production of plants, characterized with medicinal properties, is worth more than $100 billion [ 27 ]. Molecules of natural origin may have several properties, including photoprotective [ 30 ] as well as anti-inflammatory [ 9 ], antioxidant [ 25 ] or anticancer [ 26 ] via modulation of cellular signaling pathways [ 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ].…”