“…Disorder has a key involvement in interactions of IDPs/IDRs with other proteins/nucleic acids (Alterovitz et al, 2020; Cheng et al, 2007; Dunker et al, 2001, 2005; Dunker, Brown, Lawson, Iakoucheva, & Obradovic, 2002; Hegyi et al, 2007; Hsu et al, 2012, 2013; Huang et al, 2012; Oldfield et al, 2005, 2008; Oldfield & Dunker, 2014; Peng et al, 2014; Toth‐Petroczy et al, 2008; Uversky et al, 2005; Vacic, Oldfield, et al, 2007; van der Lee et al, 2014). Being conformationally malleable and adaptable and being readily tunable by their structural and chemical context, IDPs/IDRs extend the repertoire of macromolecular interactions and serve as ideal responders to regulatory cues (Holehouse & Kragelund, 2023). Furthermore, the larger interacting surface area of IDPs/IDRs (as compared to structured proteins and domains of similar protein lengths) maybe a key importance of disorder in cellular biology.…”