The molecular basis of growth hormone deficiency

Wallis, Michael

doi:10.1016/0098-2997(88)90004-0

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2003

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“…The GH gene family in humans In humans, the gene for GH (hGH-N) occurs as a member of a cluster of five related genes on chromosome 11 (Chen et al 1989; reviewed by Wallis, 1989). The other genes in this cluster include a 'vari¬ ant' GH gene (hGH-V) that codes for a protein very similar to human (h)GH, and which is now known to be expressed in the placenta (Frankenne et al 1987;Chen et al 1989), two genes for human placental lactogen (hPL; also known as human choriomammosomatotrophin, hCS) that code for identical protein sequences (hCS-A/hPL-4 and hCS-B/hPL-3), and another PL-like gene (hCS-L/hPL-1) which may not be expressed as protein.…”

Section: Introductionmentioning

confidence: 99%