The molecular basis of iron metabolism

Andrews, Nancy C.; Ganz, Tomas

doi:10.1002/9781119252863.ch13

Cited by 4 publications

(4 citation statements)

References 12 publications

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Section: Iron Requirements and Sequestration Proteins In The Human Hostmentioning

confidence: 99%

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Metal homeostasis in microbial physiology and virulence

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Section: Iron Requirements and Sequestration Proteins In The Human Hostmentioning

confidence: 99%

“…saturation in serum Andrews and Ganz, 2019). While inflammation increases hepcidin concentrations, serum Tf concentrations decrease due to the decreased iron in circulation, causing a syndrome called anemia of infection (Ganz and Nemeth, 2009).…”

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confidence: 99%

Metal homeostasis in microbial physiology and virulence

2024

Frontiers Research Topics

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Section: Iron Requirements and Sequestration Proteins In The Human Hostmentioning

confidence: 99%

“…Tf, at 80 kDa, is synthesized by hepatocytes and secreted into the serum where it solubilizes ferric iron, sequesters iron to prevent toxicity, and delivers iron into cells ( Andrews and Ganz, 2019 ). Tf is naturally found at approximately 30% iron-saturation in serum ( Ganz and Nemeth, 2015 ; Andrews and Ganz, 2019 ). While inflammation increases hepcidin concentrations, serum Tf concentrations decrease due to the decreased iron in circulation, causing a syndrome called anemia of infection ( Ganz and Nemeth, 2009 ).…”

Section: Iron Requirements and Sequestration Proteins In The Human Hostmentioning

confidence: 99%

Stealthy microbes: How Neisseria gonorrhoeae hijacks bulwarked iron during infection

Stoudenmire

Greenawalt

Cornelissen

2022

Front. Cell. Infect. Microbiol.

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Transition metals are essential for metalloprotein function among all domains of life. Humans utilize nutritional immunity to limit bacterial infections, employing metalloproteins such as hemoglobin, transferrin, and lactoferrin across a variety of physiological niches to sequester iron from invading bacteria. Consequently, some bacteria have evolved mechanisms to pirate the sequestered metals and thrive in these metal-restricted environments. Neisseria gonorrhoeae, the causative agent of the sexually transmitted infection gonorrhea, causes devastating disease worldwide and is an example of a bacterium capable of circumventing human nutritional immunity. Via production of specific outer-membrane metallotransporters, N. gonorrhoeae is capable of extracting iron directly from human innate immunity metalloproteins. This review focuses on the function and expression of each metalloprotein at gonococcal infection sites, as well as what is known about how the gonococcus accesses bound iron.

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Penna

Morante

2022

Methods in Molecular Biology

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The molecular basis of iron metabolism

Cited by 4 publications

References 12 publications

Metal homeostasis in microbial physiology and virulence

Metal homeostasis in microbial physiology and virulence

Stealthy microbes: How Neisseria gonorrhoeae hijacks bulwarked iron during infection

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