The molecular basis of oocyte growth and development

Picton, Helen M.; Briggs, David; Gosden, Roger G.

doi:10.1016/s0303-7207(98)00166-x

Cited by 195 publications

(134 citation statements)

References 73 publications

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“…Proportional hazards analyses of the mortality of the male and female probands, presented as hazard ratios (HR), 21,22 were performed separately. Independent variables were nine variables determining the probands' childhood circumstances, and ancestors' nutrition during their SGP.…”

Section: Discussionmentioning

confidence: 99%

Transgenerational response to nutrition, early life circumstances and longevity

et al. 2007

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Nutrition might induce, at some loci, epigenetic or other changes that could be transmitted to the next generation impacting on health. The slow growth period (SGP) before the prepubertal peak in growth velocity has emerged as a sensitive period where different food availability is followed by different transgenerational response (TGR). The aim of this study is to investigate to what extent the probands own childhood circumstances are in fact the determinants of the findings. In the analysis, data from three random samples, comprising 271 probands and their 1626 parents and grandparents, left after exclusions because of missing data, were utilized. The availability of food during any given year was classified based on regional statistics. The ancestors' SGP was set at the ages of 8-12 years and the availability of food during these years classified as good, intermediate or poor. The probands' childhood circumstances were defined by the father's ownership of land, the number of siblings and order in the sibship, the death of parents and the parents' level of literacy. An earlier finding of a sex-specific influence from the ancestors' nutrition during the SGP, going from the paternal grandmother to the female proband and from the paternal grandfather to the male proband, was confirmed. In addition, a response from father to son emerged when childhood social circumstances of the son were accounted for. Early social circumstances influenced longevity for the male proband. TGRs to ancestors' nutrition prevailed as the main influence on longevity.

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Section: Discussionmentioning

confidence: 99%

Transgenerational response to nutrition, early life circumstances and longevity

et al. 2007

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“…During oogenesis, oocytes synthesize substantial amounts of mRNA that are accumulated in the cytoplasm (Fair et al 1995, Hyttel et al 1997, Picton et al 1998, Memili & First 2000. During maturation, fertilization, and early embryonic development the stored maternal mRNAs are essential for development, and transcription is resumed with the activation of the embryonic genome (Niemann & Wrenzycki 2000, Thélie et al 2007.GDF9 is important for growth and proliferation of cells.…”

Section: Discussionmentioning

confidence: 99%

DNA methylation and mRNA expression profiles in bovine oocytes derived from prepubertal and adult donors

Diederich¹,

Hansmann²,

Heinzmann³

et al. 2012

Reproduction

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The developmental capacity of oocytes from prepubertal cattle is reduced compared with their adult counterparts, and epigenetic mechanisms are thought to be involved herein. Here, we analyzed DNA methylation in three developmentally important, nonimprinted genes (SLC2A1, PRDX1, ZAR1) and two satellite sequences, i.e. 'bovine testis satellite I' (BTS) and 'Bos taurus alpha satellite I' (BTaS). In parallel, mRNA expression of the genes was determined by quantitative real-time PCR. Oocytes were retrieved from prepubertal calves and adult cows twice per week over a 3-week period by ultrasound-guided follicular aspiration after treatment with FSH and/or IGF1. Both immature and in vitro matured prepubertal and adult oocytes showed a distinct hypomethylation profile of the three genes without differences between the two types of donors. The methylation status of the BTS sequence changed according to the age and treatment while the methylation status of BTaS sequence remained largely unchanged across the different age and treatment groups. Relative transcript abundance of the selected genes was significantly different in immature and in vitro matured oocytes; only minor changes related to origin and treatment were observed. In conclusion, methylation levels of the investigated satellite sequences were high (O50%) in all groups and showed significant variation depending on the age, treatment, or in vitro maturation. To what extent this is involved in the acquisition of developmental competence of bovine oocytes needs further study.

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“…One important question here is whether endocytosis and protein trafficking regulate germ-line development. Indeed, numerous reports support the argument that the endocytotic machinery is crucial to the programmed migration of germ cells, the maintenance and release of germ cells from meiotic arrest, and the differentiation of germ cells into gametes (Dersch et al, 1991;Picton et al, 1998;Segretain, 1993;Nishimura and Nakano, 1997;El-Jouni et al, 2007;Palamidessi et al, 2008;Quinones et al, 2010). Endocytosis in germ cells is probably involved in the storage of materials to construct mature spermatozoa or egg components.…”

Section: Developmental Dynamicsmentioning

confidence: 99%

The distribution of neuron-specific gene family member 1 in brain and germ cells: Implications for the regulation of germ-line development by brain

et al. 2011

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Vesicular acidification at early endosomes dissociates endocytosed receptor-ligand complexes. The ligands, receptors, or both are then directed to late endosomes for degradation or recycled back to the plasma membrane. Of neuron-specific gene (NSG) family members, early endosomal protein neuron-specific gene family member 1 (NSG1) is the most important in receptor recycling. In this study, we characterized chicken NSG1 (cNSG1). We found several functional sites related to endocytotic machinery in cNSG1 that were highly conserved with most other vertebrate NSG1 proteins. We examined the tissue and duration specificity and the temporal and spatial patterns of cNSG1 expression. cNSG1 expression was preferentially located in all regions of the brain, neuroendocrine glands, and spinal cord. Unexpectedly, cNSG1 expression was strongly detected during male and female germ-line development. Expression of NSG1 in two apparently unrelated cell types such as neurons and germ cells suggests NSG1 roles in neurons and germ-cells chemotaxis and endocytotic machinery. Developmental Dynamics 240:850-861,

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The molecular basis of oocyte growth and development

Cited by 195 publications

References 73 publications

Transgenerational response to nutrition, early life circumstances and longevity

Transgenerational response to nutrition, early life circumstances and longevity

DNA methylation and mRNA expression profiles in bovine oocytes derived from prepubertal and adult donors

The distribution of neuron-specific gene family member 1 in brain and germ cells: Implications for the regulation of germ-line development by brain

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