The Molecular Basis of Pediatric Hypertension

Ingelfinger, Julie R.

doi:10.1016/j.pcl.2006.08.005

Cited by 8 publications

(6 citation statements)

References 102 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although several factors, including sedentary lifestyle, constant stress situations and anxiety, high alcohol and salt intake, and lack of exercise, are known to increase blood pressure and the risk of developing hypertension (Kyrou et al, 2006), the findings in children with hypertension illustrate that genetic factors were important for the development of hypertension (Ingelfinger, 2006). Approximately 30-70% variability in blood pressure in human hypertension is attributed to multiple genetic factors (Pilia et al, 2006); monogenic disorders of hypertension are rare and do not explain the variability in blood pressure in the population at large.…”

Section: Introductionmentioning

confidence: 99%

Genetic variations in MOV10 and CACNB2 are associated with hypertension in a Chinese Han population

Hong¹,

Chen²,

Liu³

et al. 2013

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. Human hypertension is a complex, multifactorial disease. Multiple variants associated with hypertension have been identified in the large numbers of genome-wide association studies, meta-analysis, and case-control studies. The present study investigated the association between the single nucleotide polymorphisms (SNPs) of five candidate genes and the susceptibility and prognosis of hypertension in a Chinese Han population. A hospital-based case-control study in a Chinese Han population was carried out, including 500 hypertension patients and 506 healthy controls. The five SNP markers were detected using the Sequenom MassArray ® iPLEX System. The association of genotypes with susceptibility to hypertension was analyzed using odds Association of genetic polymorphisms and hypertension ratio, with 95% confidence interval and logistic regression. All five variants conformed to Hardy-Weinberg proportions in the controls. No significant differences were noted in the genotype distributions for AGTR1, PRRC2A, and CALCA polymorphisms in patients with hypertension (N = 500) and healthy controls (N = 506). SNP rs2932538, a variant in MOV10, was found to be significantly associated with an increased risk of hypertension. However, SNP rs4373814, a variant in CACNB2, showed a relevant association with a decreased risk of hypertension. In conclusion, the results of our case-control study confirmed the significant association of the SNP rs2932538 in MOV10 and SNP rs4373814 in CACNB2 with an increased risk of hypertension in a Chinese Han population, suggesting that the SNP rs2932538 may be a poor prognostic indicator for hypertension, while SNP rs4373814 may be a good prognostic indicator for hypertension in the same region. However, our findings need to be replicated in larger epidemiological and functional studies.

show abstract

Section: Introductionmentioning

confidence: 99%

Genetic variations in MOV10 and CACNB2 are associated with hypertension in a Chinese Han population

Hong¹,

Chen²,

Liu³

et al. 2013

Genet. Mol. Res.

View full text Add to dashboard Cite

show abstract

“…4) [174,282]. These disorders lead to aberrant distal tubular sodium reabsorption and volume expansion due to hyperaldosteronism, defects in steroid biosynthetic enzymes, and activation of sodium channels or transporters [174,[282][283][284].…”

Section: Secondary Hypertension Mendelian Forms Of Hypertensionmentioning

confidence: 99%

Pathophysiology of Hypertension

Yamaguchi

Flynn

2014

Pediatric Nephrology

View full text Add to dashboard Cite

“…A redução em meio ácido do nitrito a NO é observado principalmente no estomago 5 . Além de o pH gástrico 25,35 ter sido demonstrado como um fator muito importante na conversão do ânion nitrito a NO, a presença de antioxidantes no estômago, tais como flavonóides 40 , ou ácido ascórbico, aumenta a capacidade de formação do NO a partir do nitrito em meio ácido 41 .…”

Section: A Conversão De Nitrato a Nitrito A No E O Efeito Anti-hiperunclassified

“…A hipertensão é doença multifatorial caracterizada pela pressão arterial sistólica acima de 140mmHg e diastólica acima de 90mmHg 1 . Dentre os vários fatores que participam do estabelecimento e manutenção da hipertensão podemos citar genética familiar, obesidade e estresse entre outros 4,5 . Fisiologicamente a pressão arterial é o produto do débito cardíaco (freqüência vezes volume cardíaco) e a resistência vascular periférica.…”

Section: Introdução Hipertensão E Saúde Públicaunclassified

See 1 more Smart Citation

Estudo de mecanismos anti-hipertensivos do nitrito de sódio na hipertensão renovascular experimental

Pinheiro¹

View full text Add to dashboard Cite

Nitric Oxide plays many functional roles in physiological systems. In the cardiovascular system it participates in a unique way in the regulation of vascular tone among other functions. Dysfunctions in the production or availability of NO may compromise their physiological activity and participate in hypertension. Besides the production of NO by the nitric oxide synthase, other physiological pathways of NO production from nitrite have been described. The nitrite and nitrate are oxidation products of NO. Further nitrite is oxidized to nitrate. These three molecules are known to form a cycle in the body. Nitrate is excreted in saliva and reduced to nitrite by oral bacteria. Nitrite then is swallowed with the saliva and exerts its effects through conversion to NO. The conversion of nitrite to NO may occur by enzymatic or non-enzymatic manner. As a non-enzymatic way nitrite is reduced to NO by reaction with H + .This reaction occurs mainly in the stomach. This thesis aims to elucidate possible mechanisms responsible for the antihypertensive effects of sodium nitrite. We studied 2K1C rats treated with nitrite and nitrate and checked anti-hypertensive effects of these molecules. The increased gastric pH by omeprazole prevented the anti-hypertensive effect of nitrite and nitrate. Omeprazole did not cause any differences in plasma nitrite and nitrate. It was found that treatment with nitrite and nitrate resulted in increased nitrosylated species in the plasma, and this increase was blocked by omeprazole. We also tested the influence of the entero-salivary cycle effect of nitrite and nitrate. We found that treatment with mouthwash blunted the antihypertensive effect of nitrate but this effect did not change in animals treated with nitrite. Interestingly in 9 all experimental approaches the anti-hypertensive effect of nitrite only occurred when there was an increase in the plasma concentration of nitrosylated species

show abstract

The Molecular Basis of Pediatric Hypertension

Cited by 8 publications

References 102 publications

Genetic variations in MOV10 and CACNB2 are associated with hypertension in a Chinese Han population

Genetic variations in MOV10 and CACNB2 are associated with hypertension in a Chinese Han population

Pathophysiology of Hypertension

Estudo de mecanismos anti-hipertensivos do nitrito de sódio na hipertensão renovascular experimental

Contact Info

Product

Resources

About