The molecular biology of knockdown resistance to pyrethroid insecticides

Soderlund, David M.; Knipple, Douglas C.

doi:10.1016/s0965-1748(03)00023-7

Cited by 445 publications

(366 citation statements)

References 67 publications

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“…Large numbers of ticks were assayed by this method and this target site mechanism was found to be widespread throughout Mexico (ROSARIO-CRUZ et al, 2005 and in an outbreak strain in the United States (MILLER et al, 2007). The location of this sodium channel mutation is a bit out of the ordinary, as more arthropod sodium channel pyrethroid resistance-causing mutations are located in Domain II than the other three domains (SODERLUND; KNIPPLE, 2003). Interestingly, a survey of three pyrethroid resistant R.…”

Section: Pyrethroid Resistancementioning

confidence: 99%

Acaricide resistance mechanisms in Rhipicephalus (Boophilus) microplus

Guerrero

Lovis

Martins

2012

Rev. Bras. Parasitol. Vet.

194

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Acaricide resistance has become widespread in countries where cattle ticks, Rhipicephalus (Boophilus) microplus, are a problem. Resistance arises through genetic changes in a cattle tick population that causes modifications to the target site, increased metabolism or sequestration of the acaricide, or reduced ability of the acaricide to penetrate through the outer protective layers of the tick's body. We review the molecular and biochemical mechanisms of acaricide resistance that have been shown to be functional in R. (B.) microplus. From a mechanistic point of view, resistance to pyrethroids has been characterized to a greater degree than any other acaricide class. Although a great deal of research has gone into discovery of the mechanisms that cause organophosphate resistance, very little is defined at the molecular level and organophosphate resistance seems to be maintained through a complex and multifactorial process. The resistance mechanisms for other acaricides are less well understood. The target sites of fipronil and the macrocyclic lactones are known and resistance mechanism studies are in the early stages. The target site of amitraz has not been definitively identified and this is hampering mechanistic studies on this acaricide.Keywords: Cattle tick, resistance mechanisms, target site mutation, metabolism. ResumoA resistência aos acaricidas tornou-se amplamente difundida nos países onde os carrapatos bovinos, Rhipicephalus (Boophilus) microplus, são um problema. A resistência surge por meio de alterações genéticas em uma população de carrapatos que causam modificações no local de ação, aumento do metabolismo ou sequestro do acaricida, ou ainda redução na capacidade do acaricida em penetrar através das camadas protetoras do corpo do carrapato. Neste artigo, foram revisados os mecanismos moleculares e bioquímicos da resistência aos acaricidas que ocorrem em R. (B.) microplus. A partir de um ponto de vista dos mecanismos envolvidos, a resistência aos piretróides tem sido caracterizada em maior grau do que em qualquer outra classe de acaricida. Embora uma grande quantidade de pesquisas têm sido direcionada para a descoberta de mecanismos que causam resistência aos organofosforados, muito pouco é conhecido ao nível molecular, e essa resistência parece ser mantida por intermédio de um processo multifatorial e complexo. Os mecanismos de resistência para os demais acaricidas são bem menos compreendidos. Os alvos de ação do fipronil e das lactonas macrocíclicas são conhecidos, e os estudos dos mecanismos de ação envolvidos estão ainda em estágios iniciais. O alvo de ação do amitraz ainda não foi definitivamente identificado, e isso é limitante aos estudos dos mecanismos envolvidos na resistência a esse acaricida.Palavras-chave: Carrapato bovino, mecanismos de resistência, mutação no local de ação, metabolismo.

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Section: Pyrethroid Resistancementioning

confidence: 99%

Acaricide resistance mechanisms in Rhipicephalus (Boophilus) microplus

Guerrero

Lovis

Martins

2012

Rev. Bras. Parasitol. Vet.

194

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“…Metabolic resistance and target site insensitivity represent the two major forms of PY resistance (SODERLUND & KNIPPLE 1999, 2003. Studies have suggested that mutations in the voltage-gated sodium channel (Na V ), the target site for PY and DDT, may play a role in PY resistance (IRAC 2011).…”

mentioning

confidence: 99%

Insecticide resistance and genetic variability in natural populations of Aedes (Stegomyia) aegypti (Diptera: Culicidae) from Colombia

Aguirre-Obando¹,

Bona²,

Duque³

et al. 2015

Zoologia (Curitiba)

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“…Insecticide resistance is an inducible process rather than the function of a single enzyme or gene (Daborn et al, 2002;Soderlund and Knipple, 2003). The profiling of protein expression under trichlorphon stress in a time course mode has been recognized as a very useful approach.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of protein variants in trichlorphon-resistant Bactrocera dorsalis (Diptera; Tephritidae) larvae

Jin

Ling²,

Lin³

et al. 2012

Genet. Mol. Res.

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ABSTRACT. Functional proteins in larvae of Bactrocera dorsalis, a major fruit pest, play a central role in their resistance to organophosphorus insecticides. Changes in proteins in B. dorsalis larvae after trichlorphon treatment may have a role in the resistance response to trichlorphon. We analyzed 14 protein spots of crude proteins from B. dorsalis larvae post-treatment with trichlorphon in two-dimensional gel electrophoresis through mass spectrometry and protein sequencing. We found functional proteins that are responsible for signal transduction (pkaap and dual specificity tyrosine-phosphorylation-regulated kinase), immunity (hemolectin), synthesis and decomposition (twinstar, cathepsin B, ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 11 (3): 2608-2619 (2012) Resistance response to organophosphorus insecticides 2609 RE66325p), oxidative stress metabolism (glutathione S transferase and CG7320), energy metabolism (Act57B), and cytoskeleton formation (actin). These proteins appear to be involved in the resistance response to trichlorphon.

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The molecular biology of knockdown resistance to pyrethroid insecticides

Cited by 445 publications

References 67 publications

Acaricide resistance mechanisms in Rhipicephalus (Boophilus) microplus

Acaricide resistance mechanisms in Rhipicephalus (Boophilus) microplus

Insecticide resistance and genetic variability in natural populations of Aedes (Stegomyia) aegypti (Diptera: Culicidae) from Colombia

Characteristics of protein variants in trichlorphon-resistant Bactrocera dorsalis (Diptera; Tephritidae) larvae

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