2023
DOI: 10.3390/ijms24087482
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The Molecular Biology of Prostate Cancer Stem Cells: From the Past to the Future

Abstract: Prostate cancer (PCa) continues to rank as the second leading cause of cancer-related mortality in western countries, despite the golden treatment using androgen deprivation therapy (ADT) or anti-androgen therapy. With decades of research, scientists have gradually realized that the existence of prostate cancer stem cells (PCSCs) successfully explains tumor recurrence, metastasis and therapeutic failure of PCa. Theoretically, eradication of this small population may improve the efficacy of current therapeutic … Show more

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Cited by 6 publications
(1 citation statement)
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“…Although according to the current concept prostate cancer stem cells are among the luminal cells [13,14] with the above model it is enough to assume that prostate cancer may also arise from epithelial stem cells to explain the parallel development of adenocarcinoma and neuroendocrine cancer. The observation that the prostate cancer specific TMPRSS2-ERG rearrangement is similarly present in 50% in adenocarcinomas as well as in neuroendocrine carcinomas further supports the hypothesis of shared clonal origin [15].…”
Section: Discussionmentioning
confidence: 99%
“…Although according to the current concept prostate cancer stem cells are among the luminal cells [13,14] with the above model it is enough to assume that prostate cancer may also arise from epithelial stem cells to explain the parallel development of adenocarcinoma and neuroendocrine cancer. The observation that the prostate cancer specific TMPRSS2-ERG rearrangement is similarly present in 50% in adenocarcinomas as well as in neuroendocrine carcinomas further supports the hypothesis of shared clonal origin [15].…”
Section: Discussionmentioning
confidence: 99%