The molecular characterization and associations of porcine cardiomyopathy asssociated 5 (CMYA5) gene with carcass trait and meat quality

Xu, Xiaoling; Xu, Xuewen; Yin, Qin; Sun, Ling; Liu, Bang; Wang, Yanan

doi:10.1007/s11033-010-0334-5

Cited by 16 publications

(12 citation statements)

References 20 publications

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“…TRIM24 belongs to the superfamily of tripartite motif-containing proteins which have a role in the immune system. A member of this protein family, TRIM76 , was reported to be highly expressed in porcine skeletal muscle and significantly associated with carcass traits such as ham percentage and intramuscular fat [61]. The results of our meta-analysis suggested that ELMO1 , which is associated with the development and progress of diabetes nephropathy in humans, is a candidate gene for CONF [62].…”

Section: Discussionmentioning

confidence: 99%

Genome-wide association study for conformation traits in three Danish pig breeds

Christensen

Nielsen

et al. 2017

Genet Sel Evol

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BackgroundSelection for sound conformation has been widely used as a primary approach to reduce lameness and leg weakness in pigs. Identification of genomic regions that affect conformation traits would help to improve selection accuracy for these lowly to moderately heritable traits. Our objective was to identify genetic factors that underlie leg and back conformation traits in three Danish pig breeds by performing a genome-wide association study followed by meta-analyses.MethodsData on four conformation traits (front leg, back, hind leg and overall conformation) for three Danish pig breeds (23,898 Landrace, 24,130 Yorkshire and 16,524 Duroc pigs) were used for association analyses. Estimated effects of single nucleotide polymorphisms (SNPs) from single-trait association analyses were combined in two meta-analyses: (1) a within-breed meta-analysis for multiple traits to examine if there are pleiotropic genetic variants within a breed; and (2) an across-breed meta-analysis for a single trait to examine if the same quantitative trait loci (QTL) segregate across breeds. SNP annotation was implemented through Sus scrofa Build 10.2 on Ensembl to search for candidate genes.ResultsAmong the 14, 12 and 13 QTL that were detected in the single-trait association analyses for the three breeds, the most significant SNPs explained 2, 2.3 and 11.4% of genetic variance for back quality in Landrace, overall conformation in Yorkshire and back quality in Duroc, respectively. Several candidate genes for these QTL were also identified, i.e. LRPPRC, WRAP73, VRTN and PPARD likely control conformation traits through the regulation of bone and muscle development, and IGF2BP2, GH1, CCND2 and MSH2 can have an influence through growth-related processes. Meta-analyses not only confirmed many significant SNPs from single-trait analyses with higher significance levels, but also detected several additional associated SNPs and suggested QTL with possible pleiotropic effects.ConclusionsOur results imply that conformation traits are complex and may be partly controlled by genes that are involved in bone and skeleton development, muscle and fat metabolism, and growth processes. A reliable list of QTL and candidate genes was provided that can be used in fine-mapping and marker assisted selection to improve conformation traits in pigs.Electronic supplementary materialThe online version of this article (doi:10.1186/s12711-017-0289-2) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Genome-wide association study for conformation traits in three Danish pig breeds

Christensen

Nielsen

et al. 2017

Genet Sel Evol

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“…A study examining gene expression differences in metabolism and function between intramuscular and subcutaneous adipocytes in cattle found that SCD was highly expressed in adipocytes and closely associated with fat formation [34]. CMYA5 gene can act as a potential candidate gene affecting pig meat quality [35]. Among the DELs, we found that MSTRG.13347.…”

Section: Identi Cation Of Differentially Expressed Mrnas and Lncrnasmentioning

confidence: 82%

Identification and co-expression analysis of long noncoding RNAs and mRNAs involved in the deposition of intramuscular fat in Aohan fine-wool sheep

Han

Liu

et al. 2020

Preprint

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Background: Intramuscular fat (IMF) content has become one of the most important indicators for measuring meat quality, and levels of IMF are affected by various genes. Long non-coding RNAs (lncRNAs) are widely expressed non-coding RNAs that play an important regulatory role in a variety of biological processes; however, research on the lncRNAs involved in sheep IMF deposition is still in its infancy. Aohan fine-wool sheep (AFWS), one of China's most important meat-hair, dual-purpose sheep breed, provides a great model for studying the role of lncRNAs in the regulation of IMF deposition. We identified lncRNAs by RNA sequencing in Longissimus thoracis et lumborum (LTL) samples of sheep at two ages: 2 months (Mth-2) and 12 months (Mth-12). Results: We identified a total of 26,247 genes and 6,935 novel lncRNAs in LTL samples of sheep. Among these, 199 mRNAs and 61 lncRNAs were differentially expressed. We then compared the structural characteristics of lncRNAs and mRNAs. We obtained target genes of differentially expressed lncRNAs (DELs) and performed enrichment analyses using Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG). We found that target mRNAs were enriched in metabolic processes and developmental pathways. Three pathways were significantly enriched, namely tight junction, glycosaminoglycan biosynthesis-heparan sulfate/heparin and lysosome. Based on the analysis of critical target genes, we obtained seven candidate lncRNAs that potentially regulated lipid deposition and constructed an lncRNA-mRNA co-expression network that included MSTRG.4051.3-FZD4,MSTRG.16157.3-ULK1, MSTRG.21053.3-PAQR3, MSTRG.19941.2-TPI1, MSTRG.12864.1-FHL1,MSTRG.2469.2-EXOC6 and MSTRG.21381.1-NCOA1. We speculated that these candidate lncRNAs might play a role by regulating the expression of target genes. We randomly selected five mRNAs and five lncRNAs to verify the accuracy of the sequencing data by qRT-PCR. Conclusions: Our study provided a list of the lncRNAs and mRNAs related to intramuscular lipid deposition in sheep and laid a foundation for future research on regulatory mechanisms.

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“…Another associated gene is sideroflexin family and targeted to the mitochondrial membrane. In sheep, this gene and as important in the carrier molecule and related to the regeneration of pancreatic endocrine cells (Xi et al, 2011 described as correlated with meat quality in pigs (Xu et al, 2011), due the traits drip loss and intramuscular fat. that may play an important role in the hydrolysis of circulating peptides.…”

Section: Me Carvalhomentioning

confidence: 99%

“…In sheep, this gene and as important in the carrier molecule and related to (Xi et al, 2011). The pigs (Xu et al, 2011), due the traits drip loss and intramuscular fat. CPQ is a protein coding gene that may play an important role in the hydrolysis of circulating peptides.…”

Section: Me Carvalhomentioning

confidence: 99%

“…In sheep, this gene and as important in the carrier molecule and related to ). The CMYA5 gene was pigs (Xu et al, 2011), due to the association of is a protein coding gene that may play an important role in the hydrolysis of circulating peptides. Kasvandik (2015), studying cattle sperm reported that this protein appears to be secreted to the cel termini of peptides in the plasma membrane, contributing to membrane modifications during sperm maturation; using immunocytochemistry, they is located mainly in the sperm middle and tail, suggesting its possi al.…”

Section: Me Carvalhomentioning

confidence: 99%

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Research Article Genomic regions and genes associated with carcass quality in Nelore cattle

Carvalho¹,

Baldi²,

Santana³

et al. 2019

Genet. Mol. Res.

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Many studies have explored variability to select cattle with high genetic potential for economic interest traits. Genetic variability is a powerful tool to improve production indexes in cattle, as it also is associated with variations in meat and carcass quality traits. We made a Genome-Wide Association Study of beef cattle of Bos indicus origin, in particular Nelore animals, to identify regions and genes associated with carcass quality, by examining phenotypic and genotypic data from 909 animals. Several genes in associated regions were observed to have above 1% of the portion of explained genetic variance ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 18 (1): gmr18226 M.E. Carvalho et al. 2

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The molecular characterization and associations of porcine cardiomyopathy asssociated 5 (CMYA5) gene with carcass trait and meat quality

Cited by 16 publications

References 20 publications

Genome-wide association study for conformation traits in three Danish pig breeds

Genome-wide association study for conformation traits in three Danish pig breeds

Identification and co-expression analysis of long noncoding RNAs and mRNAs involved in the deposition of intramuscular fat in Aohan fine-wool sheep

Research Article Genomic regions and genes associated with carcass quality in Nelore cattle

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