The Molecular Interaction of Collagen with Cell Receptors for Biological Function

Abstract

Collagen, an extracellular protein, covers the entire human body and has several important biological functions in normal physiology. Recently, collagen from non-human sources has attracted attention for therapeutic management and biomedical applications. In this regard, both land-based animals such as cow, pig, chicken, camel, and sheep, and marine-based resources such as fish, octopus, starfish, sea-cucumber, and jellyfish are widely used for collagen extraction. The extracted collagen is transformed into collagen peptides, hydrolysates, films, hydrogels, scaffolds, sponges and 3D matrix for food and biomedical applications. In addition, many strategic ideas are continuously emerging to develop innovative advanced collagen biomaterials. For this purpose, it is important to understand the fundamental perception of how collagen communicates with receptors of biological cells to trigger cell signaling pathways. Therefore, this review discloses the molecular interaction of collagen with cell receptor molecules to carry out cellular signaling in biological pathways. By understanding the actual mechanism, this review opens up several new concepts to carry out next level research in collagen biomaterials.

Rigid Tissue Increases Cytoplasmic pYAP Expression in Pre-Malignant Stage of Lung Squamous Cell Carcinoma (SCC) In Vivo

“…To the best of our knowledge, this is the first study that shows the correlation between cytoplasmic pYAP and collagen content in cancer. Increased collagen content was believed to inactivate YAP through enhanced crosslinking and collagen binding with transmembrane cell surface receptors [ 54 , 62 , 63 ]. This collagen–receptor interaction was reported to increase cytoskeleton contractility [ 64 ] and inhibit apoptosis [ 65 ], which favors cell–cell contact in dense cancer tissue.…”

“…This collagen–receptor interaction was reported to increase cytoskeleton contractility [ 64 ] and inhibit apoptosis [ 65 ], which favors cell–cell contact in dense cancer tissue. For example, increased collagen content can activate β1-integrin/focal adhesion kinase receptor [ 62 , 64 ], which then activates the Rho-associated kinase (ROCK) signaling pathway, a cytoskeleton regulator that can enhance cell proliferation, cell migration, cell–cell adhesion, and even promote collagen remodeling and production [ 9 , 63 , 66 , 67 ], thereby nurturing a positive feedback loop that increases tissue rigidity, which may lead to Hippo pathway activation and YAP inactivation.…”

Osteoarthritis: modern possibilities of therapy

“…Данные некоторых исследований подтверждают, что коллагеновые биоматериалы могут регулировать гомеостаз клеток костной ткани, таких как мезенхимальные стволовые клетки, остеобласты, остеоциты, остеокласты и макрофаги костного мозга; зубных клеток, таких как фибробласты пульпы зуба и периодонтальной связки стволовых клеток; и иммунных клеток [20,21]. Анализируя исследования взаимодействия коллагена с рецепторами и его стимулирующее и ингибирующее действия на различные биологические сигнальные пути, можно сделать вывод, что регулирование специфических клеточных сигнальных путей путем манипулирования взаимодействием коллагена с его рецептором является прорывом в будущем терапевтическом лечении [22].…”

Collagen Obtained from Leather Production Waste Provides Suitable Gels for Biomedical Applications

“…Most collagen for industrial applications is currently obtained from mammalian skin, particularly from cattle, with the main and most abundant types of collagens present in the skin are types I and III [ 4 ]. However, collagen can also be extracted from alternative, marine-based resources such as fish, octopus, starfish, sea-cucumber, and jellyfish [ 5 , 6 , 7 ]. In fact, different tissues are used for the extraction of different types of collagens.…”