The Molecular Mechanism of Aluminum Phosphide poisoning in Cardiovascular Disease: Pathophysiology and Diagnostic Approach

Hosseini, Seyed Farzad; Forouzesh, Mehdi; Maleknia, Mohsen; Valiyari, Samira; Maniati, Mahmood; Samimi, Azin

doi:10.1007/s12012-020-09592-4

Cited by 36 publications

(25 citation statements)

References 78 publications

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“…In the present study, the considerably high ICU admission of aluminium phosphide poison is related to its highly toxic properties with no available efficient antidote. It induces a rapidly deteriorating cardiovascular shock as well as multiple organ failure 43 . The leading causes of ICU admission in organophosphates and opiate poisoning were respiratory failure requiring mechanical ventilation besides close hemodynamic monitoring.…”

Section: Discussionmentioning

confidence: 99%

Development of a risk prediction nomogram for disposition of acute toxic exposure patients to intensive care unit

Elgazzar

Afifi

Shama

et al. 2021

Basic Clin Pharma Tox

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Early risk stratification of acutely poisoned patients is essential to identify patients at high risk of intensive care unit (ICU) admission. We aimed to develop a prognostic model and risk‐stratification nomogram based on the readily accessible clinical and laboratory predictors on admission for the probability of ICU admission in acutely poisoned patients. This retrospective cohort study included adult patients with acute toxic exposure to a drug or a chemical substance. Patients' demographic, toxicologic, clinical and laboratory data were collected. Among the 1260 eligible patients, 180 (14.3%) were admitted to the ICU. We developed a generalized prognostic model for predicting ICU admission in patients with acute poisoning. The predictors included the Glasgow coma scale, oxygen saturation, diastolic blood pressure, respiratory rate and blood bicarbonate concentration. The model displayed excellent discrimination and calibration (optimistic‐adjusted area under the curve = 0.924 and optimistic‐adjusted Hosmer and Lemeshow test = 0.922, respectively) when internally validated. Additionally, we developed prognostic models that determine ICU admission in patients with specific poisonings. Furthermore, we constructed risk‐stratification nomograms that rank the probability of ICU admission in these patients. The developed risk‐stratification nomograms help decision‐making regarding ICU admission in acute poisonings. Future external validation in independent cohorts is necessary before clinical application.

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Section: Discussionmentioning

confidence: 99%

Development of a risk prediction nomogram for disposition of acute toxic exposure patients to intensive care unit

Elgazzar

Afifi

Shama

et al. 2021

Basic Clin Pharma Tox

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“…Poisoning with pesticides is a global health problem and leads to the deaths of about 300,000 people each year worldwide (Hosseini et al, 2020). AlP is one of the most widely used pesticides with a high mortality rate about 40-80% (Mathai and Bhanu, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…AlP produces phosphine gas (PH 3 ) in presence of the moisture and stomach acid and known as a mitochondrial toxin which leads to severe toxicity in cells (Sciuto et al, 2016). One of the main targets for phosphine gas are cardiomyocytes and AlP-induced cardiac toxicity has been reported as the main cause of death in the poisoning cases (Hosseini et al, 2020). The leading causes of death in AlP poisoning is cardiomyocyte death that leads to circulatory collapse, cardiac dysfunction and cardiac toxicity (Hosseini et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Mitochondria Permeability Transition Pore and Antioxidant Effect of Delta-9-Tetrahydrocannabinol Reduces Aluminum Phosphide-Induced Mitochondrial Dysfunction and Cytotoxicity

Salimi

Aylar

Shabani

2021

Preprint

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Purpose: Previous studies have demonstrated that phosphine gas (PH3) released from aluminum phosphide (AlP) can inhibit cytochrome oxidase in cardiac mitochondria and induce generation of free radicals, oxidative stress alteration in antioxidant defense system and cardiotoxicity. Available evidence suggests that cannabinoids have protective effects in the reduction of oxidative stress, mitochondrial and cardiovascular damages. The objective of this study was to evaluate the effects of trans-Δ-9-tetrahydrocannabinol (THC) on AlP-induced toxicity in isolated cardiomyocytes and mitochondria.Methods: Rat heart isolated cardiomyocytes and mitochondria were cotreated with different concentrations of THC (10, 50 and 100 µM) and IC50 of AlP, then cytotoxicity and mitochondrial toxicity parameters were assayed.Results: Treatment with AlP alone increased the cytotoxicity, depletion of cellular glutathione (GSH), mitochondrial reactive oxygen species (ROS) generation, lipid oxidation, mitochondria membrane potential (ΔΨm) collapse and mitochondrial swelling, when compared to control group. However, incubation with THC (10, 50 and 100 µM) attenuated the AlP-induced changes in all these parameters in a THC concentration-dependent manner. Interestingly, the obtained results showed remarkably significant protective effects of THC by attenuation the different parameters of cytotoxicity, mitochondrial toxicity and oxidative stress induced by ALP in isolated cardiomyocytes and mitochondria.Conclusion: It is the first report showing the protective effects of THC against AlP-induced toxicity, and these effects are related to antioxidant potential and inhibition of mitochondria permeability transition (MPT) pore by THC. Based on these results, it was hypothesized that THC may be used as a potential therapeutic agent for the treatment of AlP-induced mitochondrial dysfunction and cardiotoxicity.

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“…Other Insecticide-Induced Cardiotoxicity Aluminum phosphide (ALP) is one of the most widely used metal phosphides, often used as a solid fumigant to exterminate pests (Hosseini et al, 2020). Once ALP is exposed to water or acid, it will release highly toxic phosphine gas (Kariman et al, 2012).…”

Section: Insecticide-induced Cardiotoxicity Organophosphates-induced Cardiotoxicitymentioning

confidence: 99%

Recent Progress in Environmental Toxins-Induced Cardiotoxicity and Protective Potential of Natural Products

et al. 2021

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Humans are unconsciously exposed to environmental toxins including heavy metals as well as various pesticides, which have deleterious effects on human health. Accumulating studies pointed out that exposure to environmental toxins was associated with various cardiopathologic effects. This review summarizes the main mechanisms of cardiotoxicity induced by environmental toxins (cadmium, arsenic and pesticides) and discusses the potential preventive effects of natural products. These findings will provide a theoretical basis and novel agents for the prevention and treatment of environmental toxins-induced cardiotoxicity. Furthermore, the limitations of current studies, future needs and priorities are discussed.

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The Molecular Mechanism of Aluminum Phosphide poisoning in Cardiovascular Disease: Pathophysiology and Diagnostic Approach

Cited by 36 publications

References 78 publications

Development of a risk prediction nomogram for disposition of acute toxic exposure patients to intensive care unit

Development of a risk prediction nomogram for disposition of acute toxic exposure patients to intensive care unit

Inhibition of Mitochondria Permeability Transition Pore and Antioxidant Effect of Delta-9-Tetrahydrocannabinol Reduces Aluminum Phosphide-Induced Mitochondrial Dysfunction and Cytotoxicity

Recent Progress in Environmental Toxins-Induced Cardiotoxicity and Protective Potential of Natural Products

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