The Molecular Mechanism of Elevator Movement

Fujita, Setsuya; Yasuda, Yuko

doi:10.1267/ahc.36.393

Cited by 5 publications

(5 citation statements)

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“…Our immunohistochemical observations on changes in distribution of adhesion molecules during mitotic cycle unveiled the molecular mechanism of the elevator movement (Fujita and Yasuda, 2003): Adhesion apparatuses of N-cadherin-catenin-actin complexes dissociate during mitosis releasing the intercellular adhesion from the neighboring cells. Simultaneously, the release of adhesion of the integrin systems takes place and the mitotic matrix cells are rounded off and inevitably attracted to the junctional complexes on the ventricular surface (Fig.…”

Section: Molecular Mechanism Of the Elevator Movementmentioning

confidence: 71%

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The Discovery of the Matrix Cell, the Identification of the Multipotent Neural Stem Cell and the Development of the Central Nervous System

Fujita

2003

Cell Struct. Funct.

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ABSTRACT. In the early 1960s I applied 3 H-thymidine autoradiography to the study of the cells constituting the neural tube, and found that its wall was composed solely of one kind of single-layered epithelial cell, which perform an elevator movement between the mitotic and DNA-synthetic zones in the wall in accord with the cell cycle. They were identified as multipotent stem cells of the central nervous sytem (CNS) to which I gave the name of matrix cells.3 H-thymidine autoradiography also revealed the chronology of development of these matrix cells: At first they proliferate only to expand the population (stage I), then switch to differentiate specific neuroblasts in given sequences (stage II), and finally change themselves into ependymoglioblasts, common progenitors of ependymal cells and neuroglia (stage III). Based on these findings, I proposed a monophyletic view of cytogenesis of the central nervous sytem. This matrix cell theory claiming the existence of multipotent stem cells has long been the target of severe criticism and not been accepted among neuro-embryologists for a long time. Recent findings by experimental and clinical neuroscientists on the importance of stem cells have renewed interest in the nature and biology of the multipotent neural stem cells. The present paper describes how the concept of the matrix cell (multipotent neural stem cells in vivo) emerged and what has come out from this view over the last 45 years, and how the basic concept of the matrix cell theory has recently been reconfirmed after a long period of controversy and neglect.

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Section: Molecular Mechanism Of the Elevator Movementmentioning

confidence: 71%

“…Simultaneously, or sometimes lagging behind time, the release of adhesion of integrin (IGRN) from ECM takes place. Adapted from Fujita and Yasuda, 2003. cell (Fig. 12A).…”

Section: Molecular Mechanism Of the Elevator Movementmentioning

confidence: 99%

The Discovery of the Matrix Cell, the Identification of the Multipotent Neural Stem Cell and the Development of the Central Nervous System

Fujita

2003

Cell Struct. Funct.

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“…On the other hand, folliculo-stellate cells which do not produce hormones began expressing only E-cadherin and stopped expressing N-cadherin [ 7 ]. Fujita and Yasuda [ 2 ] reported that, in the matrix cell of the developing central nervous system, the dissociation and reassembly of N-cadherin-catenin complexes which occurs during mitosis causes elevator movement. It is likely that a similar mechanism plays a role during proliferation, differentiation and distribution of hormone-producing cells in the adenohypophysis.…”

Section: Resultsmentioning

confidence: 99%

Immunohistochemical Observation of Co-expression of E- and N-cadherins in Rat Organogenesis

Sakamoto

Murata

Suzuki

et al. 2008

Acta Histochem. Cytochem

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AHCCadherins are a family of transmembrane glycoproteins that mediate cell-to-cell adhesion. Isoforms, including E-and N-cadherin, have been identified and shown to regulate morphogenesis through homophilic binding. In the ontogeny, the expressions of E-and N-cadherin change spatiotemporally, and the changes in cadherin isoforms, called cadherin switching, impact the mechanical adhesion of cells. Furthermore, cadherin functions as a receptor that transfers information from outside to inside cells, and in terms of switching, it affects cell phenotypes. To observe the expression patterns of E-and N-cadherins during embryogenesis and to identify cells that transiently coexpress both cadherins, we employed a recently developed immunohistochemical double staining technique in rat fetuses. At embryonic day 9, embryonic ectodermal cells more dominantly expressed E-cadherin, while mesodermal cells more dominantly expressed N-cadherin. At embryonic day 10, the expression pattern of E-cadherin in the surface ectoderm and endoderm and that of N-cadherin in the neuroectoderm were established. After embryonic day 10, unique co-expression of E-and Ncadherin was observed in primordia, such as the bulbus cordis, otic pit, notochord, and Rathke's pouch. In the present study, it was possible to visualize the expression patterns of E-and N-cadherin during early fetal development, which enabled us to morphologically clarify cadherin switching.

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“…The interkinetic cell shows a polarized bipolar structure, whereas the M-phase cell is round. Fujita and Yasuda [23] have suggested that this morphological difference is due to a change in cell-cell adhesion that is mediated by cadherin-catenin complexes within each cell and by cadherin-cadherin interactions between the two cells. The interkinetic cells adhere to each other via cadherin-catenin complexes, and these complexes are anchored to F-actin (Fig.…”

Section: Cell Cycle-dependent Ca 2+ Mobilization and Cell-cell Adhesimentioning

confidence: 99%

“…3A). During M-phase, the cadherin-catenin complex dissociates, thereby disrupting cell-cell adhesion [23]. As a result, M-phase cells are round (Fig.…”

Section: Cell Cycle-dependent Ca 2+ Mobilization and Cell-cell Adhesimentioning

confidence: 99%

Synchronization of Ca²⁺ oscillations: a capacitative (AC) electrical coupling model in neuroepithelium

Yamashita

2010

The FEBS Journal

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Chemical coupling and DC electrical couplingThe lumen of the endoplasmic reticulum (ER) is continuous with a space between the outer nuclear membrane (ONM) and inner nuclear membrane (INM) [1][2][3]. Intracellular Ca 2+ stores are formed within the ER lumen and the space between the ONM and the INM [1,2]. In cells with a centralized nucleus surrounded by the ER (Fig. 1A), intercellular communication may be mediated by the release of a transmit- store and K + counterinflux into the store cause alternating voltage changes across the store membrane, and the voltage fluctuation induces ACs. In cases where the store membrane is closely apposed to the plasma membrane and the cells are tightly packed, which is true of neuroepithelial cells, the voltage fluctuation of the store membrane is synchronized between the cells by the AC currents through the series capacitance of these membranes. This article provides a short review of the model and its relationship to the structural organization of the Ca 2+ store. This is followed by a discussion of how the mode of synchronization of [Ca 2+ ] increase may change during central nervous system development and new molecular insights into the synchronicity of [Ca 2+ ] increase.

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The Molecular Mechanism of Elevator Movement

Cited by 5 publications

References 17 publications

The Discovery of the Matrix Cell, the Identification of the Multipotent Neural Stem Cell and the Development of the Central Nervous System

The Discovery of the Matrix Cell, the Identification of the Multipotent Neural Stem Cell and the Development of the Central Nervous System

Immunohistochemical Observation of Co-expression of E- and N-cadherins in Rat Organogenesis

Synchronization of Ca²⁺ oscillations: a capacitative (AC) electrical coupling model in neuroepithelium

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The Molecular Mechanism of Elevator Movement

Cited by 5 publications

References 17 publications

The Discovery of the Matrix Cell, the Identification of the Multipotent Neural Stem Cell and the Development of the Central Nervous System

The Discovery of the Matrix Cell, the Identification of the Multipotent Neural Stem Cell and the Development of the Central Nervous System

Immunohistochemical Observation of Co-expression of E- and N-cadherins in Rat Organogenesis

Synchronization of Ca2+ oscillations: a capacitative (AC) electrical coupling model in neuroepithelium

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Synchronization of Ca²⁺ oscillations: a capacitative (AC) electrical coupling model in neuroepithelium