The molecular mechanism of three novel peptides from C-phycocyanin alleviates MPTP-induced Parkinson's disease-like pathology in zebrafish

Abstract

Previous studies in our research group have shown that peptides isolated from C-phycocyanin (C-PC) possess various functions including antioxidant and anticancer activities. However, there is little research on peptides applied...

Nutraceutical Features of the Phycobiliprotein C-Phycocyanin: Evidence from Arthrospira platensis (Spirulina)

“…The following supporting information can be downloaded at: https: //www.mdpi.com/article/10.3390/nu16111752/s1, Table S1: Effects of C-PC or PCB-B on different disease models [20,[24][25][26][27][28][29][30][31][32][33][34]36,[38][39][40][41][43][44][45][46][47][48][49][50][51][52][62][63][64][65][66][67][68]71,72,[76][77][78][79][80][81][82][85][86][87][88][90][91][92]...…”

“…In a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced zebrafish PD model, C-PC significantly counteracted the loss of dopamine neurons and cerebral vessels, reducing the locomotor impairment in PD zebrafish [ 88 ].…”

Food-Derived Peptides: Beneficial CNS Effects and Cross-BBB Transmission Strategies

“…This improved the antioxidant system of NL5901 nematodes and promoted the life span and motor ability of PD model nematodes. Moreover, peptides MAAAHR, MPQPPAK, and MTAAAR found in phycocyanin nodes exert antioxidant, promote autophagy and antiapoptotic functions could significantly reverse the loss of dopamine neurons and cerebral blood vessels in PD zebrafish, and alleviate movement disorders . Some animal-derived peptides have also been reported.…”

“…Moreover, peptides MAAAHR, MPQPPAK, and MTAAAR found in phycocyanin nodes exert antioxidant, promote autophagy and antiapoptotic functions could significantly reverse the loss of dopamine neurons and cerebral blood vessels in PD zebrafish, and alleviate movement disorders. 30 Some animal-derived peptides have also been reported. For example, scorpion venom heat-resistant peptide (SVHRSP), which has been demonstrated to have a strong neuroprotective effect on PD, can play a neuroprotective role, and improve the motor function of PD mice by inhibiting the activation of the NLRPS inflammatory corpuscles induced by rotenone.…”

The Peptide LLTRAGL Derived from Rapana venosa Exerts Protective Effect against Inflammatory Bowel Disease in Zebrafish Model by Regulating Multi-Pathways

“…Natural products derived from marine organisms often exhibit novel chemical structures and unique physiological effects because the living environment is different from terrestrial organisms. Marine peptides which can be isolated from algae, molluscs, fish and marine by-products [ 7 , 8 , 9 ] show multi-bioactivities, such as anti-inflammatory, antihypertensive, antioxidant, antimicrobial and neuroprotective activities, etc. [ 8 , 10 , 11 , 12 , 13 , 14 ].…”