The Molecular Pathways of Pyroptosis in Atherosclerosis

Song, Dan; Li, Manman; Yu, Xue; Fan, Jiaying; Yang, Wei; Yang, Liming; Li, Hong

doi:10.3389/fcell.2022.824165

Cited by 11 publications

(10 citation statements)

References 124 publications

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“…However, pyroptosis may also be detrimental to the body, now that the deterioration of diseases occurs with pyroptosis. It is reported that pyroptosis plays an essential role in several diseases, such as cancers, atherosclerosis, and so on [ 57 , 65 , 79 ]. Respiratory diseases are considered to account for the increased mortality rate [ 64 , 67 ].…”

Section: Introductionmentioning

confidence: 99%

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Pyroptosis in inflammation-related respiratory disease

Feng

Yangzhong

et al. 2022

J Physiol Biochem

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Pyroptosis is commonly induced by the gasdermin (GSDM) family and is accompanied by the release of inflammatory cytokines such as IL-1β and IL-18. Recently, increasing evidence suggests that pyroptosis plays a role in respiratory diseases. This review aimed to summarize the roles and mechanisms of pyroptosis in inflammation-related respiratory diseases. There are several pathways involved in pyroptosis, such as the canonical inflammasome-induced pathway, non-canonical inflammasome-induced pathway, caspase-1/3/6/7/GSDMB pathway, caspase-8/GSDMC pathway, caspase-8/GSDMD pathway, and caspase-3/GSEME pathway. Pyroptosis may be involved in asthma, chronic obstructive pulmonary disease (COPD), lung cancer, acute lung injury (ALI), silicosis, pulmonary hypertension (PH), and tuberculosis (TB), in which the NLRP3 inflammasome-induced pathway is mostly highlighted. Pyroptosis contributes to the deterioration of asthma, COPD, ALI, silicosis, and PH. In addition, pyroptosis has dual effects on lung cancer and TB. Additionally, whether pyroptosis participates in cystic fibrosis (CF) and sarcoidosis or not is largely unknown, though the activation of NLRP3 inflammasome is found in CF and sarcoidosis. In conclusion, pyroptosis may play a role in inflammation-related respiratory diseases, providing new therapeutic targets.

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Section: Introductionmentioning

confidence: 99%

“…It is well established that respiratory diseases are closely related to inflammation [ 30 , 48 ]. Increasing evidence indicates that pyroptosis is crucial for inflammatory diseases [ 65 ]. Recently, accumulative studies focus on the role of pyroptosis in the inflammatory diseases of the lung [ 89 , 91 ].…”

Section: Introductionmentioning

confidence: 99%

Pyroptosis in inflammation-related respiratory disease

Feng

Yangzhong

et al. 2022

J Physiol Biochem

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“…Pyroptosis can cause inflammation that is activated by extracellular or intracellular stimuli [ 52 ] and is associated with various diseases, such as cardiovascular disease [ 53 ], Alzheimer’s disease [ 54 ], atherosclerosis [ 55 ], and muscle atrophy [ 56 ]. A recent study showed that pyroptosis occurs during dexamethasone-induced muscle atrophy [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

The Inhibition of Autophagy and Pyroptosis by an Ethanol Extract of Nelumbo nucifera Leaf Contributes to the Amelioration of Dexamethasone-Induced Muscle Atrophy

et al. 2023

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Muscle atrophy is characterized by a decline in muscle mass and function. Excessive glucocorticoids in the body due to aging or drug treatment can promote muscle wasting. In this study, we investigated the preventive effect of Nelumbo nucifera leaf (NNL) ethanolic extract on muscle atrophy induced by dexamethasone (DEX), a synthetic glucocorticoid, in mice and its underlying mechanisms. The administration of NNL extract increased weight, cross-sectional area, and grip strength of quadriceps (QD) and gastrocnemius (GA) muscles in DEX-induced muscle atrophy in mice. The NNL extract administration decreased the expression of muscle atrophic factors, such as muscle RING-finger protein-1 and atrogin-1, and autophagy factors, such as Beclin-1, microtubule-associated protein 1A/1B-light chain 3 (LC3-I/II), and sequestosome 1 (p62/SQSTM1) in DEX-injected mice. DEX injection increased the protein expression levels of NOD-like receptor pyrin domain-containing protein 3 (NLRP3), cleaved-caspase-1, interleukin-1beta (IL-1β), and cleaved-gasdermin D (GSDMD), which were significantly reduced by NNL extract administration (500 mg/kg/day). In vitro studies using C2C12 myotubes also revealed that NNL extract treatment inhibited the DEX-induced increase in autophagy factors, pyroptosis-related factors, and NF-κB. Overall, the NNL extract prevented DEX-induced muscle atrophy by downregulating the ubiquitin–proteasome system, autophagy pathway, and GSDMD-mediated pyroptosis pathway, which are involved in muscle degradation.

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“…The known signaling pathways of pyroptosis on atherosclerosis are nuclear factors such as NF-κB, AMPK, MAPK, SIRT, as well as miRNA, which may shed light on therapeutic targets for the treatment of atherosclerosis [ 111 ]. The vital role of pyroptosis in the pathogenesis of atherosclerosis has generated a few specific inhibitors or agents that target bioactive substances such as NLRP3, caspase-1, caspase-4/5/11, GSDMD, and other candidates in relation to pyroptosis pathway [ 7 ][ 81 ][ 84 ].…”

Section: Mediation and Therapeutic Targets Of Pyroptosis In Nlrp3 Inf...mentioning

confidence: 99%

Pyroptosis in NLRP3 inflammasome-related atherosclerosis

Zeng¹,

Liu²,

Huo³

et al. 2022

CST

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Pyroptosis is a proinflammatory form of programmed cell death in response to inﬂammation. It involves in the pathogenesis and outcomes of atherosclerosis characterized by NLRP3 inflammasome assembly, membrane pore formation, cell swelling, pro-inflammatory mediator and cytokine release. There are known pyroptosis molecular pathways including the caspase-1 depended canonical signaling pathway and the caspase-4/5/11 determined non-canonical signaling pathway. It is essential to explore the connection among NLRP3 inflammasome, pyroptosis and atherosclerosis, which may shed light on the potential therapeutic strategies that target pyroptosis in atherosclerotic treatment.

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The Molecular Pathways of Pyroptosis in Atherosclerosis

Cited by 11 publications

References 124 publications

Pyroptosis in inflammation-related respiratory disease

Pyroptosis in inflammation-related respiratory disease

The Inhibition of Autophagy and Pyroptosis by an Ethanol Extract of Nelumbo nucifera Leaf Contributes to the Amelioration of Dexamethasone-Induced Muscle Atrophy

Pyroptosis in NLRP3 inflammasome-related atherosclerosis

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