The molecular structure of novel pyriform spidroin (PySp2) reveals extremely complex central repetitive region

Wang, Kangkang; Wang, Shuangzhu; Tian, Luyang; Xiao, Junhua; Meng, Qing

doi:10.1016/j.ijbiomac.2019.12.027

Cited by 17 publications

(7 citation statements)

References 51 publications

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“…Pyriform silk is distinguished by its long N-linkers and short repetitive region [ 95 ]. In each of these repeats, there is a more hydrophilic, glutamine-rich segment that contrasts with the rest of the repeat sequence [ 93 ].…”

Section: Relationship Between Structural and Mechanical Properties Of...mentioning

confidence: 99%

Influence of Spider Silk Protein Structure on Mechanical and Biological Properties for Energetic Material Detection

Peng,

Liu,

Gao

et al. 2024

Molecules

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Spider silk protein, renowned for its excellent mechanical properties, biodegradability, chemical stability, and low immune and inflammatory response activation, consists of a core domain with a repeat sequence and non-repeating sequences at the N-terminal and C-terminal. In this review, we focus on the relationship between the silk structure and its mechanical properties, exploring the potential applications of spider silk materials in the detection of energetic materials.

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Section: Relationship Between Structural and Mechanical Properties Of...mentioning

confidence: 99%

Influence of Spider Silk Protein Structure on Mechanical and Biological Properties for Energetic Material Detection

Peng,

Liu,

Gao

et al. 2024

Molecules

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“…After gene expression, the two known protein components; namely, pyriform spidroins 1 (PySp1) and 2 (PySp2) possess both dry fiber and wet glue characteristics. [ 30 ] The proposed recombinant pyriform spider silk protein was found to exhibit 60%—80% high ductility during the wet spinning process. Furthermore, the stress and toughness of the fiber were further enhanced with the addition of repeating units to the three‐layer structure.…”

Section: Preparation Of Strong and Tough Artificial Fibersmentioning

confidence: 99%

Research Progress on Spider‐Inspired Tough Fibers^†

et al. 2023

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Comprehensive SummarySpider silk has attracted increasing attention due to its fascinating combination of ultra‐high tenacity high strength, and excellent elasticity. Based on the fundamental biological studies on spider silk, significant research efforts have been devoted to biotechnology and chemical synthesis to mimic or even exceed the properties of natural spider silk fibers. Moreover, the natural spider silk fiber has been simulated with the burgeoning development of numerous spinning technologies, including wet spinning, dry spinning, electrostatic spinning, and microfluidic spinning, which continuously help to optimize the properties of synthetic spider silk. The unique characteristics of natural spider silk include high refraction transmission, heat resistance, antimicrobial properties, biocompatibility, and super shrinking. Biconical recreation of spider silk with special features and extraordinary capabilities demonstrates potential applications in biomedicine, smart wearables, artificial muscles and sensors, aerospace and other domains.This article is protected by copyright. All rights reserved.

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“…Meanwhile, the expression level of repeat units in the vector is still limited by the characteristics of the vector. 9,88,89 As shown in Figure 5, the recombinant spider silk protein could express in the different host systems. The high molecular weight spider silk protein was successfully expressed by animals and plants, but it still has the disadvantage of low expression efficiency and high cost, which needs further study.…”

Section: Artificial Spider Silk Proteinmentioning

confidence: 99%

Progress in the application of spider silk protein in medicine

et al. 2021

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Spider silk protein has attracted much attention on account of its excellent mechanical properties, biodegradability, and biocompatibility. As the main protein component of spider silk, spidroin plays important role in spider spinning under natural circumstances and biomaterial application in medicine as well. Compare to the native spidroin which has a large molecular weight (>300 kDa) with highly repeat glycine and polyalanine regions, the recombinant spidroin was maintained the core amino motifs and much easier to collect. Here, we reviewed the application of recombinant spider silk protein eADF4(C16), major ampullate spidroin (MaSp), minor ampullate spidroin (MiSp), and the derivatives of recombinant spider silk protein in drug delivery system. Moreover, we also reviewed the application of spider silk protein in the field of alternative materials, repairing materials, wound dressing, surgical sutures along with advances in recombinant spider silk protein.

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The molecular structure of novel pyriform spidroin (PySp2) reveals extremely complex central repetitive region

Cited by 17 publications

References 51 publications

Influence of Spider Silk Protein Structure on Mechanical and Biological Properties for Energetic Material Detection

Influence of Spider Silk Protein Structure on Mechanical and Biological Properties for Energetic Material Detection

Research Progress on Spider‐Inspired Tough Fibers^†

Progress in the application of spider silk protein in medicine

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The molecular structure of novel pyriform spidroin (PySp2) reveals extremely complex central repetitive region

Cited by 17 publications

References 51 publications

Influence of Spider Silk Protein Structure on Mechanical and Biological Properties for Energetic Material Detection

Influence of Spider Silk Protein Structure on Mechanical and Biological Properties for Energetic Material Detection

Research Progress on Spider‐Inspired Tough Fibers†

Progress in the application of spider silk protein in medicine

Contact Info

Product

Resources

About

Research Progress on Spider‐Inspired Tough Fibers^†