The Molecular Theory of Radiation Biology

Induced chromosomal abnormality and pollen sterility in wild and cultivated urd and mung beans.

“…dicentrics and rings (Sax 1941, Wolff 1981, Errico et al 1984. The high frequencies of trival ents and multivalents do suggest that the exchange hypothesis seems to have been operative for the mutagen induced chromosomal abnormalities (Evans 1962, Chadwick andLeenhouts 1981).…”

Late Radiation Injury of the Small Intestine Clinical, pathophysiologic and radiobiologic aspects: A review

“…Exposure to ionizing radiation increases the frequency of malignant transformations in various organs and cell systems ( 106). Although several mechanisms have been suggested ( 107), radiation-induced gene mutation seems to be the single most important factor in the pathogenesis of such malignancies ( 106).…”

Multi-input Optimal Control Problems for Combined Tumor Anti-angiogenic and Radiotherapy Treatments

“…It expresses the probability of cell death in the form exp αD + βD 2 where D denotes the total radiation dose and α and β are radiosensitive parameters that, respectively, are related to the probabilities of double-strand breaks in the DNA and their repair. In this molecular theory of radiation action [2], it is assumed that the damage to DNA made by the effects of ionization radiation consists of a linear and a quadratic component. The linear part corresponds to simultaneous breaks in both DNA strands caused by a single particle which are considered lethal in the sense that the cell is no longer able to proliferate.…”