The Monitoring of Protein Markers of Inflammation and Serum Lipid Concentration in Obese Subjects with Metabolic Syndrome

Sladoje, Dragana Puhalo; Kisić, Bojana; Mirić, Dijana

doi:10.1515/jomb-2017-0009

Cited by 17 publications

(15 citation statements)

References 33 publications

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“…Similar results were previously observed, showing that recurrent implantation failure patients with MetS (RIF-MS) decreased SOD and CAT levels in comparison with a control group, whereas the MPO levels increased in the MetS group [16]. Moreover, it has been also reported that MPO activity progressively increases with obesity and MetS [44].…”

Section: Discussionsupporting

confidence: 87%

Metabolic Syndrome Is Associated with Oxidative Stress and Proinflammatory State

et al. 2020

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Metabolic syndrome (MetS) is associated with increased risk of developing diabetes and cardiovascular diseases. MetS is also characterized by an increase of oxidative stress which contributes to impaired inflammation, vascular function, and atherosclerosis. The aim was to assess the oxidative stress and inflammatory markers in plasma and PBMCs in adults with or without MetS. Antioxidant and inflammatory parameters were measured in peripheral blood mononuclear cells (PBMCs) of 80 men and 80 women over 55 to 80-years-old residing in the Balearic Islands without previously documented cardiovascular disease. Circulating leukocytes, neutrophils, lymphocytes, basophils, and monocytes were higher in MetS subjects with respect to those without MetS. Plasma levels of malondialdehyde, tumor necrosis factor α (TNFα), and interleukin 6 (IL-6) levels were higher in MetS subjects in both genders, but the superoxide dismutase activity was lower. The myeloperoxidase plasma activity was higher in the MetS male subjects. Higher activities and protein levels of catalase and glutathione reductase in PBMCs were observed in MetS subjects in both genders. Obtained data show that MetS is associated with oxidative stress and a proinflammatory state and with high antioxidant defenses in PBMCs probably derived from a pre-activation state of immune cells.

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Section: Discussionsupporting

confidence: 87%

Metabolic Syndrome Is Associated with Oxidative Stress and Proinflammatory State

et al. 2020

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“…However, data on the incidence of metabolic syndrome (MetS) in persons infected with HIV vary considerably in various observational studies (9). MetS is a complex condition characterized by physical and metabolic abnormalities, which include central obesity, increased blood pressure, dyslipidemia and hyperglycemia (10).…”

Section: Introductionmentioning

confidence: 99%

CD4/CD8 ratio as a predictor for the occurrence of metabolic syndrome in HIV / AIDS patients during 6 months of cART therapy

Gojak

Hadžiosmanović

Baljić

et al. 2019

Journal of Medical Biochemistry

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Summary Background HIV infection is characterized by progressive depletion of CD4+ T cells due to their reduced synthesis and increased destruction followed by marked activation and expansion of CD8+ T lymphocytes. CD4/CD8 ratio was traditionally described as a marker of immune system ageing in the general population, but it increasingly appears as a marker of different outcomes in the HIV-infected population. The main objective of this study is to examine the power of CD4/CD8 ratio in predicting the occurrence of metabolic syndrome (MetS) in HIV-positive patients receiving cART therapy. Methods 80 HIV/AIDS subjects were included in a retrospective case-control study. Flow cytometry was used to determine the percentage of CD4+ and CD8+ cells in peripheral blood of these patients. The values of biochemical parameters (triglycerides, HDL, blood sugar, blood counts), immunological parameters (CD4/CD8, PCR), anthropometric measurements and type of cART therapy were evaluated in this study. Results After six months of cART therapy 19 (23.8%) subjects had all the elements necessary for making the diagnosis of MetS. Using multivariate analysis CD4/CD8 ratio was statistically significant (p < 0.05) and had the largest effect on development of MetS (Wald = 9.01; OR = 0.45), followed by cART (Wald = 7.87; OR = 0.10) and triglycerides (Wald = 5.27; OR = 1.7). On the other hand, body weight and waist circumference showed no statistically significant effect on the development of MetS after six months of cART, p > 0.05. Conclusions CD4/CD8 ratio proved to be a significant marker for prediction of metabolic syndrome in HIV/AIDS patients.

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“…The most common symptoms of vitamin B12 deficiency are hematological and/or neurological disorders (5, 6). Therefore, some risk factors of vitamin B12 deficiency have been investigated including lifestyle, age, and ethnic origin (7, 8, 9, 10, 11, 12, 13). Moreover, genetic predisposition was demonstrated in vitamin B12 deficiency.…”

Section: Introductionmentioning

confidence: 99%

“…For instance, mutations and polymorphisms in transport proteins such as transcobalamin TCN, gastric intrinsic factor GIF and metabolic enzymes such as methylenetetrahydrofolate reductase MTHFR have been associated with vitamin B12 deficiency. Other vitamin-B12 related abnormalities like homocysteinemia and neural tube defect (NTD) have also been associated with genetic variants in these genes (13, 14, 15, 16, 17, 18, 19, 20, 21, 22).…”

Section: Introductionmentioning

confidence: 99%

“…Another MTHFR variant, 1298A>C (NM_005957.4: c.1286A>C, rs1801131), does not cause increased homocysteine levels in heterozygous or homozygous individuals, but combined heterozygous genotypes of c.1298A>C and c.677C>T result in an outcome similar to c.677C>T homozygous individuals (31, 32, 33). Recent studies have associated the c.677C>T variant with vitamin B12 deficiency and homocystinuria (13, 14, 15). In the present case-control study, we investigated the association of the c.677C>T and c.1298A>C variants in the MTHFR gene with vitamin B12 deficiency in a subset of the Jordanian population living in the northern part of the country.…”

Section: Introductionmentioning

confidence: 99%

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Association Between MTHFR 677C>T Polymorphism and Vitamin B12 Deficiency: A Case-Control Study

Al‐Batayneh¹,

Zoubi²,

Shehab³

et al. 2018

Journal of Medical Biochemistry

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SummaryBackgroundVitamin B12 (cobalamin) deficiency is a prevalent worldwide health concern. Several factors are associated with vitamin B12 deficiency including lifestyle, genetic predisposition, and malfunctions in the absorption and transport of vitamin B12. In the current case-control study, we aimed at investigating the association between MTHFR polymorphisms and vitamin B12 deficiency in a Jordanian population.MethodsTwo polymorphic sites of the MTHFR gene (c.677C>T, rs1801133 and c.1286A>C, rs1801131) were analyzed using RFLP and DNA sequencing in a group of vitamin B12 deficient individuals (45 males and 55 females). As a control, 100 matching individuals (age and sex) with vitamin B12 levels > 200 ng/mL were also recruited for this study.ResultsThe MTHFR c.677C>T variant was significantly associated with vitamin B12 deficiency in individuals from northern Jordan. The frequency of the homozygous MTHFR c.677C>T genotype was significantly higher in B12 deficient individuals in comparison with the control group (X2 = 8.397, p = 0.0150). The T allele frequency showed significant association with vitamin B12 deficiency in the study population (OR= 1.684, 95% CI: 1.116 to 2.542, p = 0.017). On the other hand, the MTHFR c.1286A>C variant did not show significant association with vitamin B12 deficiency in the selected population.ConclusionsOur results showed a significant association between homozygous MTHFR c.677C>T variant and T allele frequencies and vitamin B12 deficiency in the Jordanian population.

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The Monitoring of Protein Markers of Inflammation and Serum Lipid Concentration in Obese Subjects with Metabolic Syndrome

Cited by 17 publications

References 33 publications

Metabolic Syndrome Is Associated with Oxidative Stress and Proinflammatory State

Metabolic Syndrome Is Associated with Oxidative Stress and Proinflammatory State

CD4/CD8 ratio as a predictor for the occurrence of metabolic syndrome in HIV / AIDS patients during 6 months of cART therapy

Association Between MTHFR 677C>T Polymorphism and Vitamin B12 Deficiency: A Case-Control Study

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