The monkeypox diagnosis, treatments and prevention: A review

Khattak, Saadullah; Rauf, Mohd Ahmar; Ali, Yasir; Yousaf, Muhammad Tufail; Liu, Zhihui; Wu, Dongdong; Ji, Xin‐Ying

doi:10.3389/fcimb.2022.1088471

Cited by 23 publications

(19 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 2022, the contagious viral disease human monkeypox spread quickly, triggering a worldwide health emergency [ 55 ]. The MPXV genomes have been widely studied and published, but very little is known about the encoded proteome of the virus.…”

Section: Discussionmentioning

confidence: 99%

Fragment-Based Approaches Identified Tecovirimat-Competitive Novel Drug Candidate for Targeting the F13 Protein of the Monkeypox Virus

Ali

Imtiaz²,

Muhammad

et al. 2023

Viruses

Self Cite

View full text Add to dashboard Cite

Monkeypox is a serious public health issue in tropical and subtropical areas. Antivirals that target monkeypox proteins might lead to more effective and efficient therapy. The F13 protein is essential for the growth and maturation of the monkeypox virus. F13 inhibition might be a viable therapeutic target for monkeypox. The in silico fragment-based drug discovery method for developing antivirals may provide novel therapeutic options. In this study, we generated 800 compounds based on tecovirimat, an FDA-approved drug that is efficacious at nanomolar quantities against monkeypox. These compounds were evaluated to identify the most promising fragments based on binding affinity and pharmacological characteristics. The top hits from the chemical screening were docked into the active site of the F13 protein. Molecular dynamics simulations were performed on the top two probable new candidates from molecular docking. The ligand–enzyme interaction analysis revealed that the C2 ligand had lower binding free energy than the standard ligand tecovirimat. Water bridges, among other interactions, were shown to stabilize the C2 molecule. Conformational transitions and secondary structure changes in F13 protein upon C2 binding show more native three-dimensional folding of the protein. Prediction of pharmacological properties revealed that compound C2 may be promising as a drug candidate for monkeypox fever. However, additional in vitro and in vivo testing is required for validation.

show abstract

Section: Discussionmentioning

confidence: 99%

Fragment-Based Approaches Identified Tecovirimat-Competitive Novel Drug Candidate for Targeting the F13 Protein of the Monkeypox Virus

Ali

Imtiaz²,

Muhammad

et al. 2023

Viruses

Self Cite

View full text Add to dashboard Cite

show abstract

“…IMV is liberated upon cell lysis, whereas EEV is produced when cells come into contact with actin tails, enabling the virus to quickly disseminate over long distances within the host body. 14…”

Section: Viral Morphology and Genomementioning

confidence: 99%

Global Re-emergence of Monkeypox: A Synoptic Review

Memariani,

Memariani

2024

Ibnosina Journal of Medicine and Biomedical Sciences

View full text Add to dashboard Cite

As the coronavirus disease 2019 pandemic continues to rage, the unprecedented manifold increase in monkeypox (mpox) cases throughout the world is raising qualms about a possible pandemic. As of January 2024, the disease has been reported in around 116 countries, with nearly 92,500 confirmed cases and 170 deaths. In this mini-review, we have endeavored to cover multiple aspects of the mpox disease. Mpox virus is an enveloped double-stranded DNA virus that belongs to the Orthopoxvirus genus. The disease is endemic in certain African countries. Until recently, however, the disease was rarely reported in Europe and the United States. In contrast to the previous outbreaks outside Africa, reported cases in the 2022 outbreak did not travel to the endemic areas. Superspreading events at mass gatherings, multiple-partner sexual encounters, and international travel were major drivers of the recent global outbreak of mpox. The 2022 mpox virus may have undergone accelerated evolution. It diverges from the related 2018 to 2019 viruses by around 50 single-nucleotide polymorphisms, some of which brought about amino acid changes in immunogenic surface glycoprotein B21. Differential diagnosis for mpox could be quite challenging since it can masquerade as a wide variety of illnesses. Worse still, some patients may be asymptomatic or show subtle symptoms. The infection is confirmed by conventional or real-time polymerase chain reaction on lesion material. Although there is no specific therapy approved for mpox infections, two antivirals (tecovirimat and brincidofovir) and vaccinia immune globulin may be used. Vaccines also provide protection against mpox when properly administered prior to exposure. Finally, the implementation of preventive measures is of paramount importance, especially in regions where mpox transmission is widespread and among high-risk populations.

show abstract

“…Suppose you are homosexual, bisexual, or multisexual and have had sex with males. In that case, you can get vaccinated against mumps if you are at risk of coming into contact with an infected person or if your sex partner has tested positive for the virus [ 63 ].…”

Section: Pharmacological Measures For Prevention and Treatmentmentioning

confidence: 99%

Monkeypox virus (MPXV): A Brief account of global spread, epidemiology, virology, clinical features, pathogenesis, and therapeutic interventions

Islam,

Mumin,

Haque

et al. 2023

Infectious Medicine

View full text Add to dashboard Cite

The monkeypox diagnosis, treatments and prevention: A review

Cited by 23 publications

References 74 publications

Fragment-Based Approaches Identified Tecovirimat-Competitive Novel Drug Candidate for Targeting the F13 Protein of the Monkeypox Virus

Fragment-Based Approaches Identified Tecovirimat-Competitive Novel Drug Candidate for Targeting the F13 Protein of the Monkeypox Virus

Global Re-emergence of Monkeypox: A Synoptic Review

Monkeypox virus (MPXV): A Brief account of global spread, epidemiology, virology, clinical features, pathogenesis, and therapeutic interventions

Contact Info

Product

Resources

About