The monocyte counts to HDL cholesterol ratio in obese and lean patients with polycystic ovary syndrome

Abstract

BackgroundWomen with polycystic ovary syndrome are more likely to suffer from obesity, insulin resistance, and chronic low-grade inflammation. In fact, the excessive activation of monocytes exacerbates oxidative stress and inflammation. However, high-density lipoprotein cholesterol neutralizes the pro-inflammatory and pro-oxidant effects of monocytes. The aim of this study is to investigate whether monocyte counts to high-density lipoprotein cholesterol ratio can predict the inflammatory condition in patients with polycystic ovary syndrome.MethodsIn this cross-sectional study, a total of 124 women (61 of them with polycystic ovary syndrome and 63 age-matched healthy volunteers) were included in the study population. Obese polycystic ovary syndrome patients (n = 30) with a body mass index of ≥25 kg/m2 and lean polycystic ovary syndrome patients (n = 31) with a body mass index of < 25 kg/m2 were compared to age-and body mass index-matched healthy subjects (30 obese and 33 non-obese).ResultsThe monocyte counts to high density lipoprotein cholesterol values in women with polycystic ovary syndrome were significantly higher than in control subjects (p = 0.0018). Moreover, a regression analysis revealed that body mass index, the homeostasis model assessment of insulin resistance and the high sensitivity C-reactive protein levels were confounding factors that affected the monocyte counts to high density lipoprotein cholesterol values. Additionally, a univariate and multivariate logistic regression analysis demonstrated that the increased monocyte counts to high density lipoprotein cholesterol values were more sensitive than the other known risk factors (such as increased body mass index, homeostasis model assessment of insulin resistance and high sensitive C-reactive protein levels) in the prediction of the inflammation in patients with polycystic ovary syndrome.ConclusionThe present study demonstrated that the monocyte count to high density lipoprotein cholesterol may be a novel and useful predictor of the presence of polycystic ovary syndrome.

Obesity induces ovarian inflammation and reduces oocyte quality

“…These data suggest that PCOS exacerbates obesity-dependent ovarian inflammation and oxidative stress (Ressler et al 2015). Distinct metabolic differences between obesity and PCOS include hyperandrogenemia, that is, obese women without PCOS have circulating total testosterone concentrations similar to lean control women (Keskin Kurt et al 2014, Alshammari et al 2017, Usta et al 2018. Other hormones increased in obese PCOS patients compared to obese women include insulin/glucose, LH andE2 (Keskin Kurt et al 2014, Usta et al 2018).…”

“…Based on these data, it is clear that obese women with PCOS have similar inflammatory and oxidative stress phenotypes to obese women. It should also be noted that there are PCOS women who have a normal BMI (Alshammari et al 2017, Li et al 2017, Usta et al 2018. Therefore, there are obese women without PCOS and lean women with PCOS.…”

Investigation of monocyte HDL ratio as an indicator of inflammation and complete blood count parameters in patients with acne vulgaris

“…Anti-inflammatory effect of MHR depends on the pro-inflammatory and pro-oxidative effects of monocytes and the anti-inflammatory effect of HDL especially on endovascular system. 17,18 Kanbay et al 13 reported that MHR is an independent predictor factor for cardiovascular events in patients with chronic renal disease and that it is associated with decreased glomerular infiltration ratio. It has also been reported that in patients with Behçet's disease, MHR is associated with flow-mediated dilatation of brachial artery.…”

Gender, BMI and fasting hyperglycaemia influence Monocyte to-HDL ratio (MHR) index in metabolic subjects

“…Recently, leukocytes' subtypes have been considered useful systemic inflammation markers [6] as well as neutrophil-to-lymphocyte ratio (NLR) [7,8], platelet-to-lymphocyte ratio (PLR) [9,10], lymphocyte-to-monocyte ratio (LMR) [11,12]and monocyte-to-HDL ratio (MHR) [13][14][15][16][17][18] indexes. Furthermore, several studies underlined the link between NLR, PLR, LMR, MHR and cardiovascular diseases, like peripheral arterial occlusive disease, coronary artery diseases (including myocardial infarction), atrial fibrillation and aortic alterations but the association with MS is still not well established [12,16,[19][20][21].…”