The mononuclear nickel(II) complex bis(azido-κN)bis[2,5-bis(pyridin-2-yl)-1,3,4-thiadiazole-κ²N²,N³]nickel(II) protects tomato fromVerticillium dahliaeby inhibiting fungal growth and activating plant defences

Abstract

These results demonstrated that the coordination of the ligand with Ni associated with the azide as a coligand resulted in an improvement in its biological activity by both inhibiting the growth of V. dahliae and activating plant defence responses. © 2016 Society of Chemical Industry.

Functional Analogues of Salicylic Acid and Their Use in Crop Protection

“…Tomato/Verticillium dahliae (Laboratory) [97] Bis((2,5-bis(pyridine-2-yl)-1,3,4-thiadiazole-di-azido copper(II)) (CuLN3)2…”

“…It provides an excellent blast control lasting for more than two months. Despite of its direct antifungal activity, it is able to dramatically enhance the activity of several enzymes that are involved in plants defenses, such as peroxidase (POX), polyphenol oxidase (PPO), phenyl alanine ammonia lyase (PAL), tyrosine ammonia lyase (TAL), and catechol-OTomato/Verticillium dahliae (Laboratory) [97] Bis((2,5-bis(pyridine-2-yl)-1,3,4-thiadiazole-di-azido copper(II)) (CuLN 3 ) 2…”

“…Furthermore, several metallic complexes harboring Ni or Cu as transient metal were synthetized and proved to activate SAR against Verticillium wilt. Their protection ability was associated with modulation of ROS accumulation and priming the activity of several plant defense-related enzymes, including peroxidase and polyphenol oxidase [96][97][98]. However, further experiments are needed to determine whether they act in similar way to BTH or not.…”

Synthesis and Antiproliferative Activity of Thiadiazole Peptidomimetic Derivatives

“…[2～4] 、抗炎 [5] 、抗病毒 [6] 、抗 疟疾 [7] 、抗结核病 [8,9] 、抗焦虑、抗抑郁 [10] 、镇静、抗惊 厥 [11] 等生物活性; 在农药方面噻二唑衍生物还具有调 节植物生长 [12] 、抗植物黄萎病 [13] …”

“…在前期研究结果的基础上, 围绕 1,3,4-噻二唑母核 结构, 分别在 5-位和 2-位引入不同结构的片段对前期结 构进行改造, 合成了 37 个结构新颖的类肽目标化合物, 其结构经 1 H NMR, 13 C NMR, HRMS 确证. 在体外抗肿 瘤细胞增殖活性的评价中, 多数目标化合物均表现出较 好的抗肿瘤增殖活性, 其中 2 位引入苯丙氨酸和甘氨酸 的类肽化合物 6d 表现出最佳的抗肿瘤细胞增殖效果, 其抑制 PC-3 细胞增殖的活性优于阳性对照药 AT-101.…”