The More Effective Mosquito Repellents Tested at the Orlando, Fla., Laboratory, 1942–471

Travis, B. V.; Morton, F. A.; Jones, Howard A.; Robinson, John H.

doi:10.1093/jee/42.4.686

Cited by 26 publications

(12 citation statements)

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“…The testing of over 6000 chemicals from 1942 to 1947 in a variety of research institutions led to the identification of multiple successful repellent chemistries [20,21,22,23]. This work established a number of independent research projects that inevitably identified one of the most effective and widely used insect repellents to date, N , N -diethyl- meta -toluamide (DEET).…”

Section: A Brief History Of Repellentsmentioning

confidence: 99%

Current and Future Repellent Technologies: The Potential of Spatial Repellents and Their Place in Mosquito-Borne Disease Control

Norris

Coats

2017

IJERPH

141

100

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Every year, approximately 700,000 people die from complications associated with etiologic disease agents transmitted by mosquitoes. While insecticide-based vector control strategies are important for the management of mosquito-borne diseases, insecticide-resistance and other logistical hurdles may lower the efficacy of this approach, especially in developing countries. Repellent technologies represent another fundamental aspect of preventing mosquito-borne disease transmission. Among these technologies, spatial repellents are promising alternatives to the currently utilized contact repellents and may significantly aid in the prevention of mosquito-borne disease if properly incorporated into integrated pest management approaches. As their deployment would not rely on prohibitively expensive or impractical novel accessory technologies and resources, they have potential utility in developing countries where the burden of mosquito-borne disease is most prevalent. This review aims to describe the history of various repellent technologies, highlight the potential of repellent technologies in preventing the spread of mosquito-borne disease, and discuss currently known mechanisms that confer resistance to current contact and spatial repellents, which may lead to the failures of these repellents. In the subsequent section, current and future research projects aimed at exploring long-lasting non-pyrethroid spatial repellent molecules along with new paradigms and rationale for their development will be discussed.

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Section: A Brief History Of Repellentsmentioning

confidence: 99%

Current and Future Repellent Technologies: The Potential of Spatial Repellents and Their Place in Mosquito-Borne Disease Control

Norris

Coats

2017

IJERPH

141

100

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“…As well as being bactericides, the 2-substituted derivatives of both types of compound have insecticidal properties, and a number have been prepared and evaluated (see tables) as repellants for mosquitoes (107,109), beetles of the genus Tribolium (which feed on flour and grain) (112), and deerfly (rather unsuccessfully in this case) (100). Since such compounds were to be used in sprays of various types, their effect on paint and plastic surfaces has been studied (59).…”

Section: Pesticidesmentioning

confidence: 99%

Condensation Products of Glycerol with Aldehydes and Ketones. 2-Substituted m-Dioxan-5-ols and 1,3-Dioxolane-4-methanols

Showler¹,

Darley²

1967

Chem. Rev.

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“…Much work and progress in the identification and evaluation of efficacious compounds and mixtures were reported by Granett and Haynes at Rutgers University,49 the Naval Medical Research Institute, Bethesda, MD, and largely the Orlando, FL, USDA Laboratory, Bureau of Entomology and Plant Quarantine, FL, from 1942 to 1947,50 which was supported by the USDA Office of Scientific Research and Development and the US Army 51. The large‐scale screening effort evaluated approximately 6000 chemicals37, 50–52 against several dipteran species (the yellow‐fever mosquito, Aedes aegypti L., a malaria mosquito, Anopheles quadrimaculatus Say, and the stable fly, Stomoxys calcitrans L.) and found only a small percentage to equal that of existing standards. A report summarized the most active chemicals tested (59 in total) in the USDA Orlando, FL, laboratory.…”

Section: Structural Diversity Of Chemical Repellentsmentioning

confidence: 99%

Mosquito repellents: a review of chemical structure diversity and olfaction

2010

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Research on mosquito chemical repellents continues to advance, along with knowledge of mosquito olfaction and behavior, mosquito-host interactions and chemical structure. New tools and technologies have revealed information about insect olfactory mechanisms and processing, providing a more complex approach for the interpretation of how chemical repellents influence host-seeking and feeding behavior. Even with these advances, there is still a large amount of information contained in the early works on insect repellents. Many of the standard test methods and chemicals that are still used for evaluating active repellents were developed in the 1940s. These studies contain valuable references to the activity of different structural classes of chemicals, and serve as a guide to optimization of select compounds for insect repellency effects.

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The More Effective Mosquito Repellents Tested at the Orlando, Fla., Laboratory, 1942–471

Cited by 26 publications

References 0 publications

Current and Future Repellent Technologies: The Potential of Spatial Repellents and Their Place in Mosquito-Borne Disease Control

Current and Future Repellent Technologies: The Potential of Spatial Repellents and Their Place in Mosquito-Borne Disease Control

Condensation Products of Glycerol with Aldehydes and Ketones. 2-Substituted m-Dioxan-5-ols and 1,3-Dioxolane-4-methanols

Mosquito repellents: a review of chemical structure diversity and olfaction

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