The morphokinetics algorithm based on data from day 5 blastocyst transfer (KIDScoreD5 version 3) is also useful for embryo selection in day 6 blastocyst transfer

Abstract

Purpose To analyze whether the morphokinetics algorithm based on data from day 5 blastocyst transfer (KIDScoreD5 version 3) can predict the pregnancy rate of both day 5 and day 6 blastocyst transfers. Methods The relationship between KIDScoreD5 and clinical pregnancy rate was evaluated using the Cochran–Armitage test and receiver‐operating characteristic (ROC) curve analysis. Results A positive correlation was observed between the KIDScoreD5 value and clinical pregnancy rate for both day 5 ( p = 0.0003) and day 6 blastocysts ( p = 0.0019) using the Cochrane–Armitage test. ROC curve analysis showed that the area under the curve (AUC) of KIDScoreD5 for clinical pregnancy was 0.627 (0.575–0.677, p < 0.0001) for day 5 blastocysts and 0.685 (0.571–0.780, p = 0.0009) for day 6 blastocysts. The combined analysis of both day 5 and day 6 blastocysts also showed an AUC of 0.680 (0.636–0.720, p < 0.0001), suggesting that it is possible to select embryos that are more likely to result in pregnancy. Conclusions KIDScoreD5 could predict pregnancy not only in day 5 blastocysts but also in day 6 blastocysts. When both day 5 and day 6 blastocysts are vitrified, embryo selection by KIDScoreD5 is possible with a high prediction ability of pregnancy.

Optimal Embryo Selection: The Irreplaceable Role of the Embryologist in an Age of Advancing Technology

“…Overall, our study agrees with published data that have shown that both morphologic and morphokinetic parameters have a role in selecting blastocyst embryos for transfer [ 3 , 6 , 16 , 17 ] and even on day 3 can predict embryo competence. [ 7 , 8 ] However, when comparing morphologic to morphokinetic parameters on day 3, the expertise of an embryologist was superior to the morphokinetic model with an AUC closer to 1 (0.66 vs. 0.58 respectively).…”