1962
DOI: 10.1182/blood.v19.3.313.313
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The Morphologic Responses of the Lymphoid System to Homografts. I. First and Second Set Responses in Normal Rabbits

Abstract: The morphologic responses of the lymphoid system of the rabbit were studied. The results demonstrated: (a) the proliferation of a characteristic cell, the "hemocytoblast", within lymphoid centers; (b) architectural changes in lymph nodes and spleen, at first characterized by enlargement of follicles and germinal centers, later by effacement of normal landmarks and finally by reconstitution of lymphatic structures; (c) a barely perceptible plasmocytic response, especially in the first set reaction. … Show more

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Cited by 71 publications
(8 citation statements)
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“…They appear to play their part by moving directly to the allogenic source (35). Thus Weiner et al (36) have described "graft rejection cells," which conform to the structure of lymphocytes, in the bed of a homograft undergoing rejection, and Andr~ et al (2) have described hemocytoblasts, which appear to be plasma cells, in the lymph node draining the region of a homograft. Lymphocytes and plasma cells are among the small free cells of the hematopoietic and connective tissues whose cytoplasm contains ribosomes and which thereby have an affinity for basic dyes such as methylene blue, pyronin, and toluidine blue.…”
Section: Discussionmentioning
confidence: 99%
“…They appear to play their part by moving directly to the allogenic source (35). Thus Weiner et al (36) have described "graft rejection cells," which conform to the structure of lymphocytes, in the bed of a homograft undergoing rejection, and Andr~ et al (2) have described hemocytoblasts, which appear to be plasma cells, in the lymph node draining the region of a homograft. Lymphocytes and plasma cells are among the small free cells of the hematopoietic and connective tissues whose cytoplasm contains ribosomes and which thereby have an affinity for basic dyes such as methylene blue, pyronin, and toluidine blue.…”
Section: Discussionmentioning
confidence: 99%
“…Tumors were transplanted in 10-to 12-week old CSH/Anf mice' by placing small chunks of GCSHED Gardner Lymphosarcoma subcu-No. 3 taneously in the flank of the animal by means of a Gauge 18 trocar, or by injection of 2 x 106 tumor cells in 0.1 ml of a monodisperse suspension. The medium used to prepare the tumor cell or lymph node suspensions was a modified Eagles's minimum essential medium (a-MEM),t without sodium bicarbonate.…”
Section: Tumor Transplantation and Irradiationmentioning
confidence: 99%
“…This observation, coupled with the high local and axillary failure rate in lymphadenectomized mice, would support the hypothesis that the removal of the regional lymph nodes precludes the inactivation of the surviving population of irradiated tumor cells at the primary site or in the lymph nodes, and this is No. 3 probably due to a derangement of the immunologic response.…”
Section: Cancer September 1973mentioning
confidence: 99%
“…Indeed, it is comparable to the effect of a skin homograft on the lymph nodes of non-tolerant animals. In the latter, the immune response, which also appears before external indications of graft rejection are apparent (2), is initially limited to the regional lymph nodes but later may involve more distant nodes (2). In tolerant mice, the host v e r s u s graft reaction seems more chronic and it is therefore not surprising that contralateral lymph nodes also exhibit an immunological activity.…”
Section: Discussionmentioning
confidence: 99%
“…It is interesting that the onset of immunological reactivity in the spleen coincides with the loss of chimerism in these post-tolerant mice (17). Others (2)(3)(4) have shown that a skin graft rejection usually involves the lymph nodes only, whereas the injection of a homologous cell suspension is followed by an immune response in both spleen and lymph nodes. It appears, then, that at this time the post-tolerant mice not only manage to reject their skin homografts with participation of the lymph nodes, but also rid themselves, with the help of the spleen, of the circulating donor cells.…”
Section: Discussionmentioning
confidence: 99%