The morphological and clinical features of membranoproliferative glomerulonephritis in adults

Böhle, A.; Hv, Gärtner; Fischbach, H.; Bock, Kirsten; Edel, H. H.; Frotscher, Ulrich; Kluthe, R.; Mönninghoff, W; Scheler, F.

doi:10.1007/bf00432802

Cited by 26 publications

(8 citation statements)

References 16 publications

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“…However, this difference is ob served mainly during the later stages of the disease, after the 13th year from onset, as shown by the survival curves. It is still not clear whether lobular and classical MPGN have a different prognosis [4,7,9].…”

Section: Discussionmentioning

confidence: 99%

“…It is still unclear whether these different subgroups have any relation to prognosis [4,11], and whether various aetiopathogenetic data can be related to different clinical features and evolution.…”

Section: Introductionmentioning

confidence: 99%

“…As regards the prognostic importance of single histological or clinical parameters, there are few reports in the literature [4,9]. Furthermore, recent studies show that this nephropathy is not really a single entity [19,23] based on the finding of different capillary wall alterations [10,11], immunohistological pat terns [2,10], or different serum complement profiles [15,17,18,23].…”

Section: Introductionmentioning

confidence: 99%

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The Prognostic Value of Some Clinical and Histological Parameters in Membranoproliferative Glomerulonephritis (MPGN)

Belgiojoso

Tarantino

Colasanti

et al. 1977

Nephron

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112 cases of MPGN, whose diagnosis was made on light microscopy, were reviewed. Histological examination showed 66 cases of ‘classical’ MPGN, 33 of MPGN with a lobular pattern and 13 of MPGN with epithelial crescents. In 11 patients dense intramembranous deposits were observed. On immunofluorescence (95 cases) 62 patients showed deposits of C3 together with immunoglobulins, 20 had a predominant deposition of C3 and in 13 C3 alone was present. At the moment of biopsy 57 patients had nephrotic syndrome, 43 hypertension, 43 impaired renal function and 65 hypocomplementaemia. In 23 cases, one or more episodes of macroscopic haematuria occurred. The actuarial survival was 70% after 10 years and 50% after 20 years from onset. At last observation 25 patients were dead or on haemodialysis, 22 had impaired renal function, 62 had normal renal function and 2 were in complete remission. The histological variety with epithelial crescents had a significantly worse outcome. The presence of dense deposits or of any specific immunofluorescence pattern had no prognostic significance. Nephrotic syndrome, renal function impairment and hypertension indicated a poor prognosis : however, macroscopic haematuria or hypocomplementaemia did not influence the outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Prognostic Value of Some Clinical and Histological Parameters in Membranoproliferative Glomerulonephritis (MPGN)

Belgiojoso

Tarantino

Colasanti

et al. 1977

Nephron

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“…18 Series originating from Western countries cited 450 cases of MCGN, of which 342 (76%) were type I or type III and 108 (24%) were type II. [19][20][21][22] In light of this, the absence of type II MCGN in our series seems very relevant.…”

Section: Discussionmentioning

confidence: 97%

Spectrum of Renal Disease in Saudi Arabia

et al. 1990

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“…However, with a few ex ceptions [47] most authors agree that within the heterogeneous group of disorders em braced by the term 'MPGN' dense deposits disease represents an homogeneous entity easily distinguishable from MPGN with subendothelial deposits, on the following bases: (a) the original morphological alteration of C3, mg/100 ml the basement membranes, involving nearly the whole nephron; (b) the presence of C 3 in the kidney without either the early comple ment components or immunoglobulins; (c) the characteristic abnormalities of the comple ment profile and the high incidence of C3 Nef in the serum; (d) the high frequency of recur rence in the transplanted kidney, which may be an almost invariable event.…”

Section: The Place O F Dense Deposits In the Spectrum O F Primary mentioning

confidence: 99%

Dense Deposits Disease

Droz¹,

Zanetti²,

Nôël³

et al. 1977

Nephron

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The morphological and clinical features of membranoproliferative glomerulonephritis in adults

Cited by 26 publications

References 16 publications

The Prognostic Value of Some Clinical and Histological Parameters in Membranoproliferative Glomerulonephritis (MPGN)

The Prognostic Value of Some Clinical and Histological Parameters in Membranoproliferative Glomerulonephritis (MPGN)

Spectrum of Renal Disease in Saudi Arabia

Dense Deposits Disease

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