The Morphological and Pathophysiological Features of the Liver in Elderly Patients

Калинин, А. Л.

doi:10.51523/2708-6011.2016-13-1-3

Cited by 7 publications

(2 citation statements)

References 20 publications

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“…Калинин А. Л. (2016) отмечает повышение уровня билирубина, а именно появление и увеличение содержания коньюгированного билирубина на 19,5% в среднем возрасте, на 33,4% -в пожилом и на 43% -в старческом, что автор объясняет снижением экскреторной функции печеночных клеток [30]. По мнению Gan L. et al (2011) возраст-ассоциированные структурные изменения могут существенно повлиять на морфологию, физиологию и окислительную способность печени [31].…”

Section: возрастные изменения гепатобилиарной системыunclassified

Metabolic-associated fatty liver disease and older age

Sabirov,

Karshina,

Sabirova

et al. 2024

ECG

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With the growing obesity epidemic around the world, metabolic associated fatty liver disease (MAFLD), formerly called non-alcoholic fatty liver disease (NAFLD), has become a common cause of liver disease, including in older age groups, the incidence of which is increasing significantly due to significant social change economic development and improvements in health care over recent years. While NAFLD primarily focuses on the accumulation of fat in the liver, MAFLD considers both the presence of fatty tissue in the liver and associated metabolic risk factors such as diabetes mellitus, dyslipidemia or obesity, providing a more detailed approach to diagnosis and treatment of steatotic liver disease. Thus, the introduction of the term MAFLD reflects a more comprehensive approach to encompass the diverse spectrum of patients affected by this disease and recognizes the complex relationship between metabolic disorders and liver health. Age-associated structural changes can significantly affect the morphology, physiology and oxidative capacity of the liver. With age, the weight of the liver decreases, the functionality of liver cells decreases, leading to a decrease in the rate of protein synthesis, its participation in fat, carbohydrate, pigment, water-electrolyte metabolism decreases, detoxification function and vitamin synthesis are inhibited. That is, the involutive effect on the structure and functional activity of the liver during the aging process, the presence of comorbidity and features of structural and functional changes in MAFLD in elderly people require a special approach in choosing tactics for managing this group of patients. The review article examines data from scientific studies on the prevalence and diagnosis of MAFLD, taking into account involutive changes in the liver in elderly people.

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Section: возрастные изменения гепатобилиарной системыunclassified

Metabolic-associated fatty liver disease and older age

Sabirov,

Karshina,

Sabirova

et al. 2024

ECG

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“…In the older age group mainly chronic diseases occur, namely cardiovascular pathology, cerebrovascular changes, disorders of the musculoskeletal system, cerebral circulation, cancer. In order to influence chronic processes, it is necessary to lead a healthy lifestyle and abide by a healthy diet, which in turn will be beneficial for the organism as a whole [31,32].…”

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Characteristics of the nutritional status of the elderly and senile age with alimentary-dependent diseases

Janalina

Akhmetova

2020

J Clin Med Kaz

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Aging is not a disease, it is a physiological process of vital activity of the body as a result of which changes in functional and adaptation balance occur, that is, deviations in terms of health and are mainly the result of changes in cell structure and changes in biochemical and metabolic functions, as well as the prevalence of chronic diseases. One of the significant environmental factors that have a direct impact on the health and life expectancy of older people is rational and complete nutrition. Rational and balanced nutrition in the elderly and senile age affects the development of aging and the characteristic functional abnormalities in the organs and systems of the body. Nutrition in the elderly and senile is expressed by an imbalance of nutrients in the diet, such as protein, vitamins and minerals, which, in turn, can cause alimentary-related diseases. Preventing diseases and increasing life expectancy should be for every individual a credo in life -that is, common rules in life, such as playing sports, defeating stress, eating quality food and drinking water, preventing the appearance and development of diseases

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Rats caudal vena cava hemodynamics features in different age periods

Andreeva

Telia

Ustarova

2022

Regional blood circulation and microcirculation

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Introduction. Liver hemodynamics age-related features studying is promising area of portal and caudal vena cava and hepsatic artery of rats hemodynamics exploration.Aim was to determine qualitative and quantitative hemodynamic paremeters of the laboratory rats caudal vena cava of different genders and ages.Materials and methods. The study was conducted on 60 mongrel rats (males and females, 120–170 g) divided into three age groups. The first group included 20 rats aged 1 month, the second – 20 rats aged 6–12 months and the third – 20 rats aged more than 18–24 months. The study of caudal vena cava qualitative and quantitative hemodynamic parameters was performed by ultrasound scanners. Animals were anaesthesized by zoletil-xylazine. Digital data were processed by methods of variational statistics.Results. All animals showed the antegrade caudal vena cava blood flow. The spectrum of blood flow differed in the number, shape of teeth and phase. The most animals showed three-phase spectrum not depend on the animals gender and age. The diameter of the vein did not depend on the gender. In the I and II age groups, the predominance of the volumetric blood flow rate in the CPV in males compared with females was within 10 % (R=0.98 and R=0.37, respectively), in the III age group, the relationship was not statistically significant (R=–0.03). The diameter and maximum systolic blood flow velocity in the caudal vena cava increased slightly (within 3 %) with the age of the animals (R=0.64 and R=0.43, respectively). Volumetric blood flow rate decreased within 4 % with increasing age (R=0.42).Conclusion. The spectrum of rats caudal vena cava blood flow differed in the number, shape of waves and phase. In most animals it was three-phase. In all animals the direction of blood flow was antegrade. The phase of the spectrum was not affected by the animals gender and age. There was no statistically significant dependence of the diameter and linear velocity of blood flow on the gender. The volumetric blood flow rate was slightly higher in males (within 10 %) compared to females. The diameter and the maximum systolic blood flow velocity increased slightly (within 3 %) with the age of the animals. The indicator of the volumetric blood flow rate decreased within 4 % with increasing age.

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The Morphological and Pathophysiological Features of the Liver in Elderly Patients

Cited by 7 publications

References 20 publications

Metabolic-associated fatty liver disease and older age

Metabolic-associated fatty liver disease and older age

Characteristics of the nutritional status of the elderly and senile age with alimentary-dependent diseases

Rats caudal vena cava hemodynamics features in different age periods

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