The morphology and distribution of peptide-containing neurons in the adult and developing visual cortex of the rat. II. Vasoactive intestinal polypeptide

McDonald, John K.; Parnavelas, John G.; Karamanlidis, A.N.; Brecha, Nicholas C.

doi:10.1007/bf01153521

Cited by 129 publications

(29 citation statements)

References 33 publications

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“…It is difficult to compare the overall proportions in peptide-positive cells reported in studies of different laboratories, since these proportions necessarily depend on the sensitivity of the method used. The comparison of our results on VIP and CRF innervation with those obtained in the rat (McDonald et al, 1982b;Merchenthaler et al, 1982;Connor and Peters, 1984;Merchenthaler, 1984) suggest that the proportion of VIP-positive cells is somewhat larger in the rat cortex than in the cat cortex, while the reverse is true for CRF. Our own unpublished observations on the rat visual cortex support this view.…”

Section: Datrlbution Of Peptlde-contaming Neuronssupporting

confidence: 66%

“…CCK-positive cells, however, are mainly bitufted or multipolar in the cat cortex and chiefly bipolar or multipolar in the rat cortex. Another exception is the morphology of VIP-positive cells, which are virtually all bipolar in the rat cortex (McDonald et al, 1982b;Connor and Peters, 1984;Eckenstein and Baughman, 1984), but are either bipolar or bitufted in the cat.…”

Section: Datrlbution Of Peptlde-contaming Neuronsmentioning

confidence: 99%

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Heterogeneity of GABAergic cells in cat visual cortex

Demeulemeester¹,

Vandesande²,

Orban³

et al. 1988

J. Neurosci.

156

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Antibodies against neuropeptides and against a vitamin D-dependent calcium-binding protein (CaBP) label small cells with nonpyramidal-like morphology in the cat visual cortex (areas 17, 18, and 19). Since GABAergic cells are interneurons, a double-staining procedure was used to test for the coexistence of cholecystokinin (CCK), somatostatin (SRIF), neuropeptide Y (NPY), corticotropin-releasing factor (CRF), vasoactive intestinal polypeptide (VIP), and CaBP with glutamic acid decarboxylase (GAD). Our results show that CRF and VIP do not coexist with GAD, while the 3 other peptides and CaBP do. Hence GAD-positive cells can be subdivided into 4 broad groups: (1) cells that are only GAD-positive, (2) cells that are GAD- and CaBP-positive, (3) GAD- positive neurons also containing CCK, and (4) GAD-positive cells that also contain SRIF. A small subset of class 2 also contains SRIF and most cells of class 4 also contain NPY. The 4 classes of GAD-positive cells differ in laminar position: class 1 predominates in layers IV and V, classes 2 and 3 in the upper laminae (II and III), and class 4 in the deepest layer (VI).

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Section: Datrlbution Of Peptlde-contaming Neuronssupporting

confidence: 66%

Section: Datrlbution Of Peptlde-contaming Neuronsmentioning

confidence: 99%

Heterogeneity of GABAergic cells in cat visual cortex

Demeulemeester¹,

Vandesande²,

Orban³

et al. 1988

J. Neurosci.

156

View full text Add to dashboard Cite

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“…Thus, LAMP expression clearly delineates prefrontal and lateral sulcal gustatory and visceral cortex at least within a few days of the genesis of the first neurons that comprise these areas. Of those molecules that appear to be unique to subpopulations of mature cortical neurons, LAMP is one of the earliest expressed, found at a time similar to the more ubiquitously distributed DARPP-32 (Foster et al, 1987) and occurring substantially earlier than the initial detection of most cortical neuropeptides and neurotransmitters (McDonald et al, 1982;Gall et al, 1984;Miller, 1986;Chun et al, 1987).…”

Section: Resultsmentioning

confidence: 99%

“…The expression of the protein occurs relatively early in development, indicating that neurons comprising 'medial prefrontal and lateral perirhinal sulcal cortex are designated as part of limbic circuitry almost from the time of their initial differentiation. This chemical identity occurs before cytoarchitectonically distinct boundaries are formed and prior to the detectable expression of many neurotransmitters (McDonald et al, 1982;Gall et al, 1984;Miller, 1986;Chun et al, 1987), indicating that LAMP may be involved in events that occur prior to synaptic transmission.…”

Section: Specificity Of Lamp Immunoreactivity In Axon Tractsmentioning

confidence: 99%

A unique membrane protein is expressed on early developing limbic system axons and cortical targets

1988

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The limbic system-associated membrane protein (LAMP) is a 64 kDa protein that, in the adult brain, is present in cortical and subcortical regions comprising the limbic system (Levitt, 1984). The developmental expression of LAMP was studied in fetal rat brains to determine the specific patterns of distribution and the cellular elements that exhibit LAMP immunoreactivity. Light microscopic immunocytochemical analysis revealed that LAMP is expressed on neurons and their growing axons early in fetal development, at a time coincident with pathway formation and differentiation of limbic system nuclei. In the forebrain, where limbic system structures are heavily concentrated, immunoreactivity appears on subpopulations of axons in a temporal sequence that correlates with the time of formation of pathways carrying limbic system axons. Thus, staining is evident first at embryonic day (E) 15 on fibers within the internal capsule coursing from the diencephalon to cortex. LAMP immunoreactivity appears over the next 3 d in the anterior commissure, fornix, and corpus callosum. Ultrastructural immunocytochemical analysis reveals dense surface staining of fascicles of developing axons and growth cones. The axonal staining is transient, disappearing during the second postnatal week of development. In cerebral cortex, cells in presumptive limbic cortical regions such as lateral perirhinal sulcal cortex and prefrontal cortex are LAMP immunoreactive from the inception of the cortical plate. These cortical regions are clearly delineated from surrounding unstained nonlimbic areas as early as E15. Thus, LAMP expression in the cortex may represent one of the earliest markers of specific cytoarchitectonic areas.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…Whole-cell recordings and intracellular staining were performed in juvenile animals [postnatal day 16 (P16) to P24], an age range easily amenable to patch-clamp recordings and comparable with the age used in many previous studies of cortical interneurons in vitro. Cortical inhibitory neurons have acquired many of their adult electrophysiological, morphological and molecular characteristics by the beginning of the third postnatal week (McDonald et al, 1982;Miller, 1986a;Eadie et al, 1987;Minelli et al, 2003;Long et al, 2005). For preparation of brain slices, mice were anesthetized deeply with isoflurane (Abbott Laboratories, Abbott Park, IL) and decapitated.…”

Section: Methodsmentioning

confidence: 99%

Distinct Subtypes of Somatostatin-Containing Neocortical Interneurons Revealed in Transgenic Mice

Ma¹,

Hu²,

Berrebi³

et al. 2006

J. Neurosci.

389

559

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GABA-releasing inhibitory interneurons in the cerebral cortex can be classified by their neurochemical content, firing patterns, or axonal targets, to name the most common criteria, but whether classifications using different criteria converge on the same neuronal subtypes, and how many such subtypes exist, is a matter of much current interest and considerable debate. To address these issues, we generated transgenic mice expressing green fluorescent protein (GFP) under control of the GAD67 promoter. In two of these lines, named X94 and X98, GFP expression in the barrel cortex was restricted to subsets of somatostatin-containing (SOMϩ) GABAergic interneurons, similar to the previously reported "GIN" line (Oliva et al., 2000), but the laminar distributions of GFP-expressing (GFPϩ) cell bodies in the X94, X98, and GIN lines were distinct and nearly complementary. We compared neurochemical content and axonal distribution patterns of GFPϩ neurons among the three lines and analyzed in detail electrophysiological properties in a dataset of 150 neurons recorded in whole-cell, current-clamp mode. By all criteria, there was nearly perfect segregation of X94 and X98 GFPϩ neurons, whereas GIN GFPϩ neurons exhibited intermediate properties. In the X98 line, GFP expression was found in infragranular, calbindin-containing, layer 1-targeting ("Martinotti") cells that had a propensity to fire low-threshold calcium spikes, whereas X94 GFPϩ cells were stuttering interneurons with quasi fast-spiking properties, residing in and targeting the thalamo-recipient neocortical layers. We conclude that much of the variability previously attributed to neocortical SOMϩ interneurons can be accounted for by their natural grouping into distinct subtypes.

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The morphology and distribution of peptide-containing neurons in the adult and developing visual cortex of the rat. II. Vasoactive intestinal polypeptide

Cited by 129 publications

References 33 publications

Heterogeneity of GABAergic cells in cat visual cortex

Heterogeneity of GABAergic cells in cat visual cortex

A unique membrane protein is expressed on early developing limbic system axons and cortical targets

Distinct Subtypes of Somatostatin-Containing Neocortical Interneurons Revealed in Transgenic Mice

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