The morphology control of hydroxyapatite microsphere at high pH values by hydrothermal method

Qi, Yong-Cheng; Shen, Juan; Jiang, Qiying; Jin, Bo; Chen, Jiwei; Zhang, Xia

doi:10.1016/j.apt.2015.04.008

Cited by 56 publications

(22 citation statements)

References 33 publications

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“…A famous case of studies inspired by the way the nature proceeds is the well-known example of hydroxyapatite Ca 10 (PO 4 ) 6 (OH) 2 Contents lists available at ScienceDirect journal homepage: www.elsevier.com/locate/jssc which remains always of great interest since the pioneer reports dealing with its structure in 1964 [1]. Nowadays, due to potential applications, numerous works are devoted to the control of the shape of the particles that is strongly influenced by pH, precursors used and their amounts, time, reaction temperature [2][3][4], by the saturation of the reaction system [5] etc.…”

Section: A Few Points Relating To Hydrothermal Synthesismentioning

confidence: 99%

“…Nowadays, due to potential applications, numerous works are devoted to the control of the shape of the particles that is strongly influenced by pH, precursors used and their amounts, time, reaction temperature [2][3][4], by the saturation of the reaction system [5] etc. Moreover, the preparation of asymmetric micro and nano-particles has been explored by searching for different strategies and fabrication process in order to "reproduce" the existing particle formats in nature [6,7] since nano/ micro-structure, porosity, surface quality are key parameters for imaging promising devices particularly for medical purposes [8].…”

Section: A Few Points Relating To Hydrothermal Synthesismentioning

confidence: 99%

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Hydrothermal synthesis for new multifunctional materials: A few examples of phosphates and phosphonate-based hybrid materials

Rueff

Poienar

Guesdon

et al. 2016

Journal of Solid State Chemistry

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Section: A Few Points Relating To Hydrothermal Synthesismentioning

confidence: 99%

Section: A Few Points Relating To Hydrothermal Synthesismentioning

confidence: 99%

Hydrothermal synthesis for new multifunctional materials: A few examples of phosphates and phosphonate-based hybrid materials

Rueff

Poienar

Guesdon

et al. 2016

Journal of Solid State Chemistry

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“…HAp can be used as a adorbent of dyes [1] and heavy metals [2], catalyst for chemical reactions such as the Michael-type addition and methane oxidation [3], [4] and biosensor [5]. The several research also has been done to fabrication of HAp such as hydrothermal [6], microwave [7] and precipitation [8].…”

Section: Introductionmentioning

confidence: 99%

The Effect of pH on Synthesis of Hydroxyapatite from Geloina Coaxans Shell

Yanti

Nia

2017

IJPS

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The effect of pH on synthesis of hydroxyapatite from Geloina coaxans shell has been done by precipitation method. Geloina coaxans shells and several phosphate sources (NH4)2 HPO4 and H3PO4 were used as precursors on synthesis of HAp. Synthesis of HAp was done with molar ratio of precursors 1,67 and pH of solution were varied at 10, 12, 13, and 14. The result proved that nano-HAp can be obtained successfully and shown that pH value was a significant parameter variable on synthesis HAp that can influence crystalinity and purity of HAp. Using Schererr equation, particle size of HAp powder of (NH4)2HPO4 was 26,69 while H3PO4 was 40 nm respectively.Keywords: Geloina coaxans, HAp, (NH4)2HPO4 and H3PO4 ABSTRAK Pengaruh pH pada sintesis hidroksiapatit mengggunakan cangkang lokan (Geloina coaxans) telah dilakukan menggunakan metode pengendapan. Cangkang lokan (Geloina coaxans) dan beberapa sumber posfat seperti (NH4)2 HPO4 dan H3PO4 telah digunakan sebagai prekursor pada sintesis senyawa hidroksiapatit. Sintesis senyawa hidroksiapatit ini dilakukan dengan perbandingan molar prekursor 1,67 dan pH larutan divariasikan pada 10, 12, 13, dan 14. Hasil yang diperoleh menunjukkan bahwa nano-hidroksiapatit dapat diperoleh melalui variasi pH, dan membuktikan bahwa pH merupakan suatu parameter penting dalam sintesis hidroksiapatit yang dapat mempengaruhi kristalinitas dan kemurnian dari hidroksiapatit yang dihasilkan. Dengan menggunakan persamaan Schererr, ukuran partikel hidroksiapatit yang yang dihasilkan (NH4)2HPO4 adalah 26,69 sedangkan H3PO4 adalah 40 nm Kata kunci: Geloina coaxans, HAp, (NH4)2HPO4 and H3PO4

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“…Once a suitable function has been selected, the release profiles are evaluated depending on the derived model parameters [14][15][16] . The results obtained from in vitro release studies were plotted in different model of data treatment as follows Zero order kinetics: The zero order rates describe the systems where the drug release rate is independent of its concentration.…”

Section: Kinetics Of Drug Release Of Amd and Nfdmentioning

confidence: 99%

Untitled

2017

IJPSR

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ABSTRACT:To develop pulsatile microspheres of amlodipine and nifedipine drug release, a blend of polymer and solvent were used with pulsatile principles of drug delivery system to modified drug release pattern on and to release the drug at a particular time on the basis of lag time. In this study, we assessed the in vitro drug release pattern of the formulation prepared from different polymers ratio with the drugs of calcium channel blockers i.e. Amlodipine and Nifedipine. Different formulations of Amlodipine and Nifedipine were prepared using polymers Eudragit RS100, Eudragit S100, Carbopol 971P and polyvinyl alcohol. Optimum formulations were selected from both the drugs of pulsatile microsphere formulation such as formulation N12 from Nifedipine drug and A5 from amlodipine drug by conducting evaluation parameters for microsphere. In vitro studies were carried out for both the formulation and compared to each others. Kinetics drug released kinetics model fitted for both the drugs of optimum formulation for N12 and A5. Formulation N12 showed first order kinetics model and formulation A5 showed zero order kinetics models. Hence both the drugs showed a pulsatile effect, drug released from both the formulation at a particular lag time. The pulsatile dosage form of drug could be useful in chronopharmacotherapy of the treatment of hypertension.

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The morphology control of hydroxyapatite microsphere at high pH values by hydrothermal method

Cited by 56 publications

References 33 publications

Hydrothermal synthesis for new multifunctional materials: A few examples of phosphates and phosphonate-based hybrid materials

Hydrothermal synthesis for new multifunctional materials: A few examples of phosphates and phosphonate-based hybrid materials

The Effect of pH on Synthesis of Hydroxyapatite from Geloina Coaxans Shell

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